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2018-10-08 16:17 Ķ:

йҩ䡷

ҩơ

ƴBái Sháo

ӢRADIX PAEONIAE ALBA

ҩ

ԴƷΪëݢֲҩPaeonia lactiflora Pall. ĸġڣϴȥͷβϸ÷ˮȥƤȥƤɹɡ

״ƷԲΣƽֱƽأ518cm,ֱ12.5cmɫ򵭺ɫƼϸۣżвдغɫƤʼʵ۶ϣƽ̹ɫ΢غɫγɲ㻷ԣ߷״΢ζ

΢ࡢᡣ

𡿣1 Ʒĩưɫſࡣƴؾֱ1135μm,ڱϸУгУһϸкؾԵƿ׼Ƶֱ2065μm άΣֱ1540μm,ں΢ľߴԲƿס

2 ȡƷĩ5g50mlȻ10ӣ˹ȡҺ10mlɣӴ1ml 45ΣԻɫɺɫɫɫ

3 ȡƷĩ0.5gҴ10mlҡ5ӣ˹ҺɣҴ1mlʹܽ⣬ΪƷҺȡҩնƷҴƳÿ1ml1mgҺΪƷҺձɫ׷¼ B飬ȡҺ10μl,ֱͬһ轺DZϣȷ£״ᣨ40:5:10:0.2 Ϊչչȡɣ 5ȩҺߵɫƷɫУƷɫӦλϣͬɫߵ㡣

ơȡƬڳ΢ɫ

ưȡƬûƾȣŹڳ΢ɫÿ100ûƾ10

ζࡢᣬ΢

龭ΡƢ

ΡƽֹʹѪֹͷʹѣΣвʹʹ֫ʹѪήƣ¾Ժ

÷615g

ע⡿޼«ͬá

ժ¼йҩ䡷

ͼƬ
ҩİͼƬ

ҩǵ䡷

ҩơ

ƴBái Sháo

ҩ֣ҩƷ

ݾע

ԴΪëݢֲҩ֣ġֲ34ҩȥϴȥƤˮʹָ̳ɹɡ

ԭ̬ҩʫݣʫڴݡ֣ձݡ루ޱŽעʳa¼ûǻݡβ¼루Ŀ

ݱ5080סʴͨԲλԳʷĴΡֱ⻬ëҶ߳23ҶСҶƬԲΣ812ף24ףȶ˽⣬ШΣȫԵҶԵ߼ϸͻɫ浭ɫҶ¡Ҷɫ󣬵ڻķ֦ˣÿ25仨911ףƬ3Ҷ״10Ƭһ࣬ΣɫۺɫɫҩɫƤ35ö롣uȋ35öΣȶ˹״䡣57¡67¡

ֲɽ¡ɽȵĹľԻݴСֲ֡ӱϡɽɽɹŵȵءȫؾࡣ

״ԲΣϸȶƽֱ1020ףֱ11.8ס浭ɫ۰ɫƽ̹Ե弰ۣ˨ƤδغɫߺۣżƤסʼʵأ۶ϡҰɫ΢ɫľ߳ʾջ״ޣζ΢ᡣԸֱֳʼʵ㡢ྻΪѡ

㽭աĴȵء⣬ɽݡϡࡢϡϵȵ㽭ߣƷΪ֣Ʒѣղ߳Ϊ֣Ĵ֣н֣

ҩƣءպ뾰ʼΪҩҩ֡ĿǰҩģҩΪ֣ҩΪҰ֣ڸı֣ϵҰֶΪʹߡϸСȣ˨Ƥ۽϶࣬ɣС߲ԣƷΪΡ

ѧɷ֡ҩ߰ĵӡҩ߰Լ1.07ӷ֬֬͡͡ʡǡۡճҺʡʡβ-޴ࡣĴߺһʣԽɫá

߰ɽͷ37-߰ûʳʣ10ϣ0.1313-׻ʮᡢβ-޴إ̼ȡҶʡ

ҩáпá

ơ֣ȥʣֿСˮ˳͸̳ɹʪȾȣƬư֣ȡƬûƾܾȣùĻ΢ȡÿƬ100ûƾ10

֣ȡƬùĻ΢ɫȡ֣ȡƬùɫˮȡɡ֣ȡϸۣùڳȣƬɫȡɸȥÿƬ100÷ϸ20

١׹ۡ"ҩɵúɹɣ񵶹ϴƤͷ֮ˮδɹá"

ڡܡ"ҩƽأ"

ζᣬ

١"ζ࣬ƽ"

ڡձݡ"ͩʣ޶̡᪲ϣС׹ᡣ"

ۡ¼"ᣬƽ΢С"

龭ΡƢ

١Ʒ㾫Ҫ"̫̫"

ڡݾ衷"̫ҩΡƢѪ֡"

ΡѪΣֹʹպظвʹкʹԺ鷢ȣ¾©¡

١"аʹѪԣƼκֹʹС㣬"

ڡ¼"ͨ˳ѪУɢѪѪȥˮסСӸףΣʱкȣжʹʹ"

ۡҩۡ"ηаЯLʹѪۣͨอӵаʹѪʱȣǿ࣬ĸͣѪղͨѪʴŧ"

ܡƱݡ"ŮѪ"

ݡջӱݡ"η粹죬Ůһвǰͨˮȳȼξ񣬸ѪˣкѪ꣬ͷʹĿĿ࣬⡣"

ޡҽѧԴ"ƢθʹθֹкѪкΣƢθ"

ùţ"ƢƦвʹ棬μ洭ȣ̫ĿɬѪ㣬άຮȣูʹˮС"

ࡶϱݡ"кƢȣֹֹۣˮкոۣĸƢѪ澭ֹʹ"

÷ڷ24Ǯ衢ɢ

ע⡿麮ʹйк

١ݾע"루һ’’Ϊ֮ʹʯâηʯסС޼«"

ڡݾ衷"кʹкйʹθо֤֮"

ۡҩƷ塷"Ӽ֮"

ܡ䱾ݡ"Ƣ麮Ѫá"

θвʹ㸽Ӵ׶룬һΪȣӺҩΪϸĩÿǮʱϼҽҩ

ŧѪQأѪҩһơľǮʲݶǮǮ˰ٹǮ롣ϸУÿˮյһյʳ·ʲҩ

θ˻ѸЯLʹҩһкܺ˕һζΪɢȡذƺͣҪԡҩɢ

βѪĸʹҩȥƤʲݣˣһζֵɸÿǮذˮһյ߷֣ȥң·ʱ򡣣ʥ¼ҩ

ʹֶɽǮΪϸĩֳɰ˰¾ʱÿշһƾΪڡɹšвҩҽƷѡࡷ

θŮ£òߣҩɽϸﱣƣɸ.նǣ֭Ǯذ١

νѪֹʹҩһƣϸΪɢƻ״¶Ǯáӡ

νʹҩʲһΪĩʱǡ

η綾ʹҩ֣һˣΪĩоʢաÿϣ󷽡

ժ¼ҩǵ䡷


лݡ

ҩơ

ƴBái Sháo

ҩҩ

ҩһ,ҩʼڡƷպ뾰ʼֳࡢ׶,ƣ"ɽɽéɽ,׶ദж,С"ݡأ"֣С,ֹʹɢѪ,仨к׶ɫ"ͼأ"ҩ,һ߽ҩ,ľҩȲýҩ,ɫ׶֬,ľҩɫݶ"أ"񴦴֮,ʤѿ,֦Ҷ,ĵ,һߡĿ

ԴҩĻԴΪҩֲҩƷëҩĸ

ֲﶯ1.PaconialactifloraPall.P.albifloraPall.2.PaconialactifloraPall.var.trichocarpaBungeSternP.albifloraPall.var.trichocarpaBungeP.yuiFang

պʹأ9-10²3-4ĸȥϾˮϴ뿪ˮ5-15minӲģ񵶹ȥƤɹɻƬɹɡ

ԭ̬1.ҩ ݱ40-70cmëʴ󣬷ĴλԲΣںɫֱϲ֦ö״ĤƬҶҶ9cmλھҶ϶̣²ҶΪҶϲҶΪҶСҶΡԲλΣ7.5-12cm2-4cmȶ˽⣬ШλƫбԵ߰ɫϸݣëҶëʡԣҶҸֱ7-12cmƬ4-5ΣСȣƬ4λԲΣ1-1.5cm1-1.7cmɫ޴棻9-13Σ3.5-6cm1.5-4.5cmɫʱɫ߿ۺɫƷɫذꣻ˿7-12mmҩɫdz״ƤȶƬԲƤ2-5ëuȋλԲΣ2.5-3cmֱ1.2-1.5cmȶ˾ߴ5-6£6-8¡

2.ëҩ ֲ̬ҩҪƤ׹ëuȋ豻ë

ֲ̬1.ɽ²ݵغ¡

2.ɽعľС

Դֲ1.ֲڶࡣкʹࡣ

2.ֲڶɹšӱɽȵأضࡣ

ࡿѧ ϲůʪϺͺԡѡ㡢ˮá֡ɡֳʵɰࡣμغݵز֡컨ջ

༼ ӷֳֳָӷֳ9Ѯ֣õϿ3cmӾ빵ڣ6-10cmѹǧ161.2gÿ1hm252.5-60kg4ȥָԼº󼴿ɳ硣ֳָѿ3-4cm£õÿշֳ3-5꣬ÿ1-2ѿࣨ60-90cm×45cmѨԣÿѨ1-2꣬ϣˮԽÿ1hm230000ҡΪ߲ʵʩũҷʡ

Ժ괺ⶳʣÿ4-6Ρ10Ѯضǰȥ֦ҶԽ׷3ΣסطΪˣ⣬ʱժ١

溦 ְ߲ݲùⲡȣ顢ɭпھȫջ١溦к֩롢桢󩡢ϻȡ

״1.״ ԲΣϸϾȣ˳ֱ5-20cmֱ1-2.5cmֱ۰ɫɫϹ⻬ֱɫdzɫϴֲڣԵƼϸۡʼʵأ۶ϣҰɫ΢ɫľз״΢ζ΢ᡣԸֱֳƤɫࡢʼʵ۰ɫԴްĻѶϺΪѡ

2.΢ 棺μ¡Ψ˨༺ȥϸڵѺ

3.ĩٲƴؾֱ10-39μmڱϸУгУһϸؾάܰΣֱԼ44μmں΢ľԵƿײԣƿ׿бѷ״׹ԣеİǻڳϸ״ƽᾧ۵ҪΪ״״Եƿ׵ܣֱ30-80μmܾԵƿ׹ܰĩб⣬Եƿ1-2СݱϸԳ״ƿԼɼ޵Ѻ

4. ɫײμ¡

5.Ʒ ַĵȡһȣ8cm,вֱ1.7cm,«ͷ㡢ѿڡʵȡȣ6cmϣвֱ1.3cm,黨,ͬһƷȣ4cm,вֱ0.8cm,л,ͬһƷĵȣ̴ϸ֣м㡢ڻδȥ˨Ƥ

ָϳ߸ȼһȣ8cmϣвֱֱΪ2.21.81.5cmϣġȣ7cm,вֱ1.20.9cmϣߵȣ̲һֱ0.80.5cmϡİ־4ȼֵȡ

ѧɷ֡ҩ߰(paeoniflorin),ҩ߰(oxy-paeoniflorin),ҩ߰(benzoylpaooniflorin),߰(albi-florin),ҩ߰ͪ(paeoniflorigenone),ûʳҩ߰(galloylpaeoniflorin),β--10-ϩ-β-߰(z1s5R-β-pinen-10-yl-β-vicianoside)ҩ߰(lacioflorin)ҩ(paeoni-lactone)ABCβ-޴(β-siiosierol)ܲ߰(daucos-terol)Ӹзֵ1236-ûʳ(1236-tetra-O-galloyl-β-D-glucose)1,2,3,4,6-ûʳ(1,2,3,46-penta-O-galloyl-β-D-glucose)ӦûʳǺûʳǵȡֺ辫(catechin)ӷ͡ӷҪ(benzoic acid),ĵ(paeonol)ͷɷֹ33

ҩá1. ʹãҩˮ0.4gҩ/10gθСŤ巴Ӧ߰5-40mg/kgڻǻע䣬ʼԵСŤ塢˻кȰ巴Ӧ,50-125mg/kgǻעʱƴȰ巴ӦСŤ巨ED50Ϊ27mg/kgȰ巨ED50Ϊ21mg/kgø߷ڸҩ0.5-lСʱпɷֱǿȡСŤ巴Ӧá߰ʹÿи߼룬ͪӰ졣ã1g/kgǻעСԷǿͱƵĴãҩעҺƤעҲӳͱƵĴʱ䡣ҩ߰1mg/ֻע룬ʹ򾲣5-10mg˯ߺͼɳڡҩ߰ýʲݳɷFM100ЭͬáнĿĵãҩܶԿʿʡҩ߰Сº˹ȶнĽºͽá

2.⾷ ҩҩ߰ƽƻ⾷ãСԷʹ,ܶԿȻС,СӰ,øʲݺáֵˮ崼Һ2gҩ/kgעθ,ʹèθͳȼС,ӳƽ⾷ûƿֱûƸĩͷҲбּʹóԷӴ,мԡ,ҩҩ֧߰ܺӹƽҲһ,ܶԿ߲ӹҩȡСӹŨ˷,Ũơ

3.ס ҩҩ߰нĿãԽĸԡDz˽Ժв̶ͬãʲݳɷFM100ЭͬãԸǻëϸѪͨ͸ҲнáȡԴԼ֢ѿ׾á߰50mg/kgÿ1Σ11գԴʵԹؽáҩĵӡҩ߰ҩ߰Ҳпáҩ߰ԴӦԤãŽFM100θҺڷЭͬãҩȡҺʹθҺ

4.Ի߹ܵӰ ںܴٽϸɹܡּ0.4g/ֻθÿ1,5,ʹСǻϸɰٷʺָߡ1.2g/ֻÿ1,8,ʹƼСѪԡα-øANAEܰϸĽͻָʹѪӡʵֶϸߺҺ߾ǿá߰TGPԴԹؽףAAп׺ͻߵã50mg/kgθÿ1Σ11գAAƵͬʱʹAAǻϸߵĹ⣨H2O2Ͱ׽1IL-1ˮƽͣʹAAµϸ˿ԭӦƢܰϸIL-2ָ߰0.09-11.25μg/mlԽĸյĸǻϸͷH2O20.5-12.5μg/ml֬յIL-1ϳɺ0.5-62.5μg/mlԵ򵰰ACon AյĴƢϸIL-2Ũ˫ãŨǿŨƣЧ߳"∧"Ρ߰200mg/kgθÿ1Σ8գСٷͳӦDTHǿã5mg/kgǻע䣬ÿ1Σ5-8գԻDTHǿƼѪļپŶԿ,ԵDTHӰ졣õ¡ӫⷨʵ,߰߹˫õĻڸTϸTHTϸTsıֵйء

5.ѪϵͳӰȱ ֺҩ߰ѪܣѪáҩöѪܡעҺ2gҩ/kgעʹèѪӣмǿҩ߰Ȯ״Ѫܺ֫ѪܣмԽѪѹá߰߶ȱ5-40mg/kgǻע䣬ܼԵӳСѹȱʱ䣬20mg/kgӳѹȱʱ䣻2.5-5mg/kgעӳѹȱʱ䣬йأ40mg/kgܼС軯жȱʣֱӸϸH1ҩȱ׿ע߰ȱãH1йأȱҲֵĽйء

6.ѪҺϵͳӰ ҩȡ5mg/kg25mg/kgǻע,ʹѪصBUNŽͣЧɷ1,2,3,4,6-ûʳ1mg/ֻ2.5mg/ֻ5mg/ֻáȡأagglutininsܸƼʧѪ¼ƶѪ׿áҩ߰ע,ADPյĴѪСۼãҩ߰ҲѪСۼá

7 ֵĿýǿ׽Ϲ㡣ԹڶԽɫѪɫ˺˾͸˺˾˾󳦸˾ŧ˾θ˾տȸ˾һв̶ͬȵáɫëѢͬëѢѢ¶ŰСѿѢɫСѿѢë״СѿѢɹƤѢɫƤѢūƤҲв̶ͬȵá⣬ҩ140ԹڶԾ68-1áҩ1,2,3,4,6-ûʳпԡ

8.κͽⶾ ȡD-ǰͻùB1´ALT,ԺøSLDHͬøܻ,áѼùB1ⶾ,ȡһʱƻùصáҴȡҺԻùB1һáȡ250mg/kgθ,СT-2жԽⶾá

9.ձ뿹 ȡܸS9ҺøԣʹBAPĴлʧBAPձáûʳᣨGAûʳǣPGGʹBAPĴлʧPGGS9ҺøԡСP-388Ѫϸʵȡǿ˿ùCĿã˿ùCµİϸ١

10. ֳɷҩ߰Ԫͪ0.04С񾭼ͷȥáҩԴȩǻԭøRLARãЧɷ-O-ûʳ-β-D-Ǻ-O-ûʳ-β-D-1μg/mlRLARʷֱΪ77.661.0ҩ񾭲񾭵RLARйءˮȡ64mg/mlԴȵøãŨΪ≤16mg/mlʱӰøȴʹĵյĴݷڵøЧ۽10ӰҺش̼øڣֿ׿ϸĤϵĵ塣ȡԷ塢α-壬Ѫܽآ壬β-ǻ-β-׻ḨøAϵͳغϵͳתøв̶ͬȵáҩȡ25mg/mlԻ48/80յķʴϸ鰷ͷá

ԡԶԣҩļ״ȡ6g/kgǻע,СԷ˶ơëƺ,С2ȫθҩδ쳣ҩ߰СעLD50Ϊ3.53g/kgǻעΪ9.53g/kg,θ߰СʹǻעLD50ֱΪ125mg/kg301mg/kgС͸ǻעLD50ֱΪ159mg/kg230mG/kgθ2500mg/kgж֢״ҲǼԶԣθҩ״ȡÿ1.5g/kg3.0g/kg21աͼɼ򵰰ߡ߼ԼᣬѪҺкϸѪ쵰סѪϸݾ½ƽϸͺϸֲӣʾΪ޺ϸƶѪƢ״йأɼƢźͳѪҲӡڶԣ߰50mg/kg1000mg/kg2000mg/kgθÿ1Σ90գѪС⣬δ쳣ͻ飺˺ɳžAmes飬йϸȾɫICRС΢߰ͻԡ

1ȡƷĩ0.5gˮ10mlУ˹ҺȻҺ1Σɫʣ2ɫȡƷĩ0.5gҴ10mlҡ5min˹ҺɣҴ2mlʹܽ⣬ΪƷҺȡҩ߰ƷҴƳÿ1ml2mgҺΪƷҺȡҺ4μl, ֱͬһ轺Gϣȷ--״-ᣨ405100.2Ϊչչȡɣ5ȩҺȷ紵ߵɫƷɫУƷɫӦλϣͬɫߵ㡣

Ʒʱ־Ʒҩ߰C23H28O112.0

ơ1.֡񺯾أ"ȥƤ"׹ۡ"ɹɣ񵶹ϴƤͷˣ֮"ҽЧ"ȥ«ա顣"УȡԭҩģȥʣֿС߳͸͸бƬ

2.֡Чأ"ơ""΢""ơ"УȡƬùڣĻȣ΢ɫȡԻΣƢֹк

3.ư֡ȵ顷أ"Ƴ"Һݡ"ƽ"˴󷨡"ƽƬ"ݳԭ:"Ƭ󣬸ǹޡ"УȡƬܻƾưȣƺùĻȣɣȡÿƬ100kgûƾ10kgоֹкʹ

4.װ֡Ŀأ"׳"УȡƬ״װȣƺùڣĻȣɣȡÿƬ100kg״15kg׳ѪֹѪ

5.֡ʱۡأ""УȡΣϸùڣлȣƬɫ΢ԽɫʱȡɸȥۣÿƬ100kg20kg

6.̿Ϫķأ"̿""ջҴԡ"ҽѧĿ"Ѵԡ"УȡƬùڣȣɫˮ𾡻ǣȡɣ͸ֹ̿Ѫ⣬а֡ΰ֡ﳴ֡

Ƭ״ΪԲλԲεıƬֱ10-25mmɫ΢غɫƽмɫԵĻƺͷ״ܱߵغɫ۰ɫơʼࡣ΢ζ΢ࡢᡣ֣΢ɫżлưߡư֣ɫ΢оװ֣΢д֣ɫ΢н֣̿潹ɫ

ζࣻ᣻΢

龭ΣƢ

ΡѪӪֹʹƽΡ¾иʹ©Ժв丹ʹ֫ʹͷʹѣ

÷ڷ5-12g衢ɢ15-30g

ע⡿麮֤֮˵Ӧá޼«

1.ݾע"ʯâηʯסС޼«"2.塷"Ѫ麮ˣһԻҩԱкϲɺ"3.ݾ衷"ҩẮкʹкйʹθо֤֮"4."ƢƦѻ߼á"5.ҩƷ塷"Ӽ֮"6.䱾ݡ"Ƣ麮Ѫ߽á"

ƷԭֲΪҩҩһҩëʫ·֣硷“֮ҩ”ʱƣ“ҩ̋CԼҲCԼò”ν仨ˋCԼׯ·ңΡ“Լ紦ӡ”ʫ“ҩҲ”ƣ“ҩһ룬ʽ֮”“”ͬ塣

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ٴӦáƬ 200g㸽30g25g20gҶ̿4g50g30gĸ150gȡ80g㸽顢ߡҶϸۣɸȡ120g󶬡Ρĸݼˮ2ΣϲҺ˹ҺŨɸ࣬ĩϣȣ70ҴѹƳ1018ƬƬ0.25g,¡Ƭijغɫζ΢ࡣܵѪֹʹѪڸʹڷÿ8Ƭÿ2-3λǰ4-5շáҩƷ׼·ҩɷƼ(ڶ)1989꣩

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