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ҽҩȫ > ҩ > ҩ > C > ܺ

ܺ

2017-06-08 00:07 Ķ:

ȫвҩࡷܺ

ҩĴܺͼƬ

ƴChun Xin

ӢRHIZOMA CHUANXIONG

ܺ˕СҶܺ

ԴƷΪɡοֲܺLigusticum chuanxiong Hort.Ligusticum wallichii Franch.ĸļϵĽͻԴɫʱڣȥɳɹ󿻸ɣȥ

ԭ̬ݱ3060ף״ʲĽ״ȭΣڶоſ飬Ƥƺɫֱϲ֦ڼпգ²ɸ״Ҷ״Ҷļɡλ˫ԲΣ5⣬խᣬ͹124

״ƷΪ״ȭſ飬ֱ27cmƺɫֲжƽ¡ֽڣаݵԲξۣ²༰ֽжС״ۡʼʵ۶ϣưɫһɫɢлɫңγɲʲ״ơŨ㣬ζࡢУ΢

𡿣1Ʒ棺ľ˨Ϊ10ϸƤխɢиά,γɲԡƤ㣬γɲ㻷״򲻹ΡľʲܶλԲΣ൥лų“”Σżľά貿ϴ󡣱֯ɢжңԲΡԲλ״򣬵ɫγɲС⽥󣻱ϸиеıϸкƾ壬Բſؾ״

ĩɫɫ϶࣬ԲΡԲΡԲΡԲλΣֱ516μmԼ21μm,״״״ż24ɡƾڱϸУԲſؾ״ֱ1025μľ˨ϸɫص۳ʶΣڱҶ༺飬żɼƬϸڱн϶͵ΡΪƵܣƼƵܣֱ1450μеƵڻᣬ״Ƶ

2ȡƷĩ1gʯѣ3060棩5ml 10СʱʱʱҡãȡҺ1mlӸɺ󣬲Ӽ״1mlʹܽ⣬ټ23,5-ļ״Һ23״͵Һ2ΣԺϡ

3ȡƷĩ1gҴ20mlȻ1Сʱ˹ҺӸɣӴ2mlʹܽ⣬ΪƷҺȡܺҩ1gͬƳɶҩҺձɫ׷¼ B飬ȡҺ12μl ֱͬһ轺DZϣ-9:1Ϊչչȡ,ƣ365nm¼ӡƷɫУҩɫӦλϣͬɫӫߵ㡣

ơȥʣֿСݣϴ͸бƬ

ζ¡

龭Ρİ

ΡѪֹʹ¾ʹ֢ʹвʹʹͷʹʪʹ

÷39g

ءﴦ

ժ¼ȫвҩࡷ

ܺͼƬ

ҩǵ䡷ܺ

ҩơܺ

ƴChun Xin

ӢRHIZOMA CHIUANXIONG

ɽ󴫡ܺ˕ձݡ˕¼ܺ˕պ뾰ȸܺܺͼܺҡܺϪķ̨ܺܡܺĿ

Һݡ

ԴΪɡοֲܺƽԭС45ղΪѣɽ߶89²աڳҶɳϴɹɻɣײײȥ

ԭ̬ݱ¾ʲĽ״ȭſ顣ֱԲΣпգֱơҶ23ص״ҶСҶ35ԣԵ״ȫѻѣƬȶ˽⣬ëжëҶ917ףʱɡλڷ֦ˣжëܰСܰƬΣСɫƬ5Σжë5ԲΣȶȫԵж̼ͻ5뻨껥ҩԲΣ2ңѣ˿ϸڻ⣻ӷλ2ң2˫Ρ

ֲֲĴݡһΪࡣĴء죩"ܺ"

״ʲ״ȭſ飬48ףֱ46סɫԽ״ֽڣϲкܶԲλԲεľֱۣ515ף״²༰ֽڶۣС״¡ʼʵɫγɲԻ״洦ɢлɫС͵㡣ζࡣ

1 Ʒ棺ľ˨Ϊ10ϸƤխɢиάγɲԡƤ㡣γɲ㻷״򲻹ΡľʲܶλԲΣ൥лų""Σżľά貿ϴ󡣱֯ɢжңԲΡԲλ״򣬵ɫγɲС⽥󣻱ϸиеıϸкƾ壬Բſؾ״ĩɫɫ϶࣬ԲΡԲΡԲΡԲλΣֱ516μmԼ21μm,״״״ż24ɡƾڱϸУԲſؾ״ֱ1025μľ˨ϸɫص۳ʶΣڱҶ༺飬żɼƬϸڱн϶͵ΡΪƵܣƼƵܣֱ1450μеƵڻᣬ״Ƶܡ

2 ȡƷĩ1gʯѣ3060棩5ml 10СʱʱʱҡãȡҺ 1mlӸɺ󣬲Ӽ״ 1mlʹܽ⣬ټ 23,5-ļ״Һ 23 صļ״Һ 2ΣԺɫ

3 ȡƷĩ1gҴ20mlˮԡϼȻ1 Сʱ˹ҺӸɣӴ2ml ʹܽ⣬ΪƷҺ

ȡܺҩҺ

ձɫ׷飬ȡҺ 1 2μl ֱͬһ轺DZϣ飭9:1 Ϊչչȡɣƣ365nm ¼ӡ

ƷɫУҩɫӦλϣͬɫӫߵ㡣

ơܺȥʣֿСˮݣɹƬƴܺȡܺƬûƾȣƣùڳ΢ΪȣȡÿܺƬ100ûƾ128

ζ¡

١"ζ¡"

ڡձݡ"Ƶۡ᪲׹޶㡣ȵᣬ޶ϣ£캮"

ۡƱݡ"ζ"

ܡ"ζ΢ʣ¡"

龭Ρ

١Һݡ""

ڡҩƷ塷"ΡƢ"

ΡʪѪֹʹηͷʹΣвʹۣԽΣգѲʹӸҴ¾ʹʹвʹʹͷʹʪʹ

١"зͷʹԣλ𴴣Ѫӡ"

ڡ¼"䶯ηȥĿ٣ĸʹж伱ʹвʹں"

պ뾰"ݸѪߣ֮"

ܡҩۡ"죬²θʹ"

ݡջӱݡ"һз磬һһһѪͣ׳ǣưYѪѪ⣬Ǻ飬ѪѪӸ׸꣬ŧѪ"

ޡҽѧԴ"ѪѪͷʹ"

ùţ"ѸѪ顣"

ࡶĿ"ʪֹк"

÷ڷ12Ǯ衢ɢãĩ

ע⡿ʢ鼰֮˼ɷ

١ݾע"Ϊ֮ʹ"

ڡƷ㾫Ҫ"÷ɢ"

ۡܡ"ΡɽǶηʯʯ޼«"

ܡݾ衷"ʢ飬ϣŻ¿ԣԺ׺ʸɿʷ֮꣬"

ݡݴ¡"̵á"

ޡ䱾ݡ"Ƣʳ٣ͷʹԽá"

ϹͷĿأƫͷʹأ˷׳ȣ֫巳ۣ䶯̵ʢѪ繥棬̫ѨۣзҶ𣩰ܺ棨ȥ㸽ݣϸȥ«һ磨ȥ«һ룬ơǼʲݣfҩΪϸĩÿһǮʳ£ͷĿ塣ַܺɢ

ƫͷۣܺϸﱣƽ֮ŷ

׷Σѣ纮ಫθ̵ƫͷۣо룺ܺһΪĩΪ裬ÿʮ衣ÿһ裬ϸ£ʳ󡣣۷ܺ裩

ηͷʹܺһǮҶǮˮһӣ֣ʳǰȷ㵥

︹ʹ裩ܺͶʲݶҶҩɵػζˮȡȥɽ·һҪԡ

θ£̥У¶£ʹֹôҩ֮̽ʹֹĸ㰲̥£ϴȥУɣӣܺϴϴĩÿǮˮһСյɣһյֹһУȥ·֮塢ٽ·ָ裩

βѪΣһܺǮ루ڣǮˮ淽ࡷ

βĸʹܺϴﱣģﱣľ㣨ﱣɣ飨ȥ«룬ϴﱣʣȥƤⲢ˫ʣƣһΪϸĩÿһǮȾƵ£粻ƣˮһյҩĩǮ߷֣ȷұܺɢ

²ʹǮܺǮʮȥƤ⣬Уڽ֣˲֣ûƾơͯŮơ

СȣñĿ̫ʹĿףܺɡǮΪĩСȫļ

ٴӦáĽʹ:ȡܺ컨ȷ֣ƳƬÿ12Ƭܺ컨ҩ5Ǯÿ4Ƭշ3Ρ46ΪһƳ̡8410ȫ̼ӸͪƬÿ3Σÿ20ˣ2ҩ2ܿʼӷûƬЧ957Ч171ݹ۲죬ЧԹϵӷͪûƬߣЧδߣҩѪ֬Ӱ첻60Ծ͵ĻߣƹУͣ2015ֲĵͼʾת

ժ¼ҩǵ䡷


лݡܺ

ҩơܺ

ƴChun Xin

ӢSzechuan Lovage Rhizome, Rhizome of Szechuan Lovage

ɽܺ˕˕Ρܺ˕ȸ̨ܺܺܺܺܺܺ

ԡҺݡ

ԴҩĻԴΪɡοֲﴨܺĸ

ֲﶯLigusticum chuanxiong Hort. [L.wal-lichii auct.non Franch.]

պʹأԺ25Ѯ6ѮڳȥҶɡ

ԭ̬ݱ40-70cmȫŨʲĽ״ȭŲ¶жֱԲΣпգֱơ²Ľ״׳ӣвϵĽڲ󡣾²Ҷ߱3-10cmʣҶƬ״Σ12-15cm10-15cmĻʽ״ȫѣƬ4-5ԣ״Σ6-7cm5-6cmĩƬ״Σ2-5mm1-2mmСͷϡĶëϲҶ򻯡ɡλܰƬ3-6Σ0.5-2.5cmɡ7-20ȳ2-4cmСɡλл10-24СܰƬ2-7ΣԴɫë3-5mmݲԣԲΣȶж̼״ͻ5ҩɫ22-3mm·׹ѹ2-3mmԼ1mm͹1-5͹2-3͹6-87-8£׹9-10¡

ֲ̬ΪҩģδҰ

ԴֲҪĴϡݡϡ㽭աȵؾࡣ

ࡿѧ ϲů桢ճĻͺκˮԡɷ֡ˮáԻ΢Եɳ࣬ڹɳɰճصĻ࣬ࡢʪȴֲ

༼ õϾľڣӣֳߺ֡ߣȺ1000mϵɽ2ѮڳӴܺƸܺȥҶࣨ25-30cm×15-20cmѨԼ6cmÿѨŸܺ1öѿͷϣѹʵ3cmÿ1hm2øܺ2250-3750kg10cmʱ磬ÿѨ׳8-10꣬и2-3Σ׷1-27ѮԴɫʱȡȫ꣬¸ɺҩãСʩڻ8Ѯȡвг3-4cmСΣṩӵá֣8ϡѮࣨ25-30cm×20cm2-3cmƽʩڣѿУöѷʻڸǣõϡ档ɾ͵ߣ7ѮֱջĴܺϾ֣͵ѡʪطߣɽͬ

ʱȥDzݣȱʱӦ硣붬Խ귵ʱ׷ʻʩáҪʩ1ξǷʻɷʡ

溦 ֲγջ٣̱׷۲ʯϼ׻вҩΡҶݲ5-7·25%1000Һ⣬оȲΪܺڶ߽꣬׶80%аٳ100-150ˮҺעطε1ǰ׳棬ƽԭǰ55100̽Ҷˮպ12-24hеϻӬΪ

״״ Ϊ״ȭſ飬ֱ1.5-7cmƺɫɫֲжƽ¡ֽڣԲΰ״ۣ²༰ֽжϸС״ۡʼʵ۶ϣưɫһƣ߲״γɲ㣬ȫɢлɫ͵㡣ŨزУζ࣬΢С

ԸʼʵɫưסԴŨΪѡ

΢ 棺ľ˨Ϊ10ľ˨ϸƤխƤ㣬ɢиάγɲ㻷״򲻹ΡľʲΡľʲܶλԲΣ൥лų“V”żľά貿ϴ󡣱֯ɢжңԲΡԲλ򲻹ΣɫγɲСϸеĺƽᾧ

ĩɫɫٵԲΡԲΡԲΡԲλΣֱ5-16μmԼ21μm״״״2-4ɡڲƽᾧԲſԲ״ֱ10-25μmľ˨ϸɫص۳ʶΣڱҶ飬ϸн϶͵ΡݵܶΪƵܣеƵ໥ᣬ״ƵܡơƼԵ׵ܣֱ14-50μm

ѧɷ֡ܺຣchuanxiongzine)ļ׻ຣte-tramethylpyrazine)ݼ򺬴ᣨperlolyrine)1-5-Ǽ׻-2-߻ૻ-9h-ल[34-b][1-5hydroxymethyl-2-furyl)-9H-pyrido[34-b]indole][1]޻ligustilide)ܺ߻wallichilide)3-Ƕ̪3-butylideniphthalide)3-Ƕ-7-ǻ̪3-butylidene-7-hydroxyphthalide)[2]̪butylphthalide)[3]3S-3--4-ǻ̪[3S-3-butyl-4-hydroxyphthalide]3S-ܺӣ3S-chunxiongol)[4]3--367-ǻ-4567-ⱽ̪3-n-bntyl-3,6,7-trihydroxy-4,5,6,7-tetrahydrophthalide)[5]´ܺneocin-dilide)ܺsenkyunolide)[3]ܺsenkyunolide)BCDEFGH[˳-67-ǻ޻cis-6,7-dihydrox-yligustilide)][-67-ǻ޻trans-6,7-dihydrox-yligustilide)]J[4]KLM[6]N[4]OP[8]E-ܺ[E-senkyunolide]E[4]ܺsenkyunone)2--4-3--1-ϩӣ2-methoxy-4-(3-mnethoxy-1-propenyl)pheneol)2--[2-1-oxopentyl)-benzoic acid methyl ester][8]5-Ǽ׻-6--3--4-DZ-8-˫[3.2.1]-3-ϩ-2-ͪ[5-hydroxymethyl-6-endo-3-methoxy-4-hydroxyphenyl-8-oxa-bicyclo(321-oct-3-one][5],4-ǻ-3-ϩ4-hydroxy-3-methoxy styrene)1-ǻ-1-3--4-DZ[1-hydroxy-1-(3-methoxy-4-hydroxyphenyl)ethane]\4-ǻᣨ4-hydroxybenzoic acid)ᣨvanillic acid)ᣨcoffeic acid)ԭᣨprotocatechuic acid)[9]κᣨferulic acid)Ʒӣchrysophanic acid)ɪͪᣨsedanonic acid)L--L-ӰL-isoleucyl-L-valine anhydride)L-Ӱ-L-ӰL-valyl-L-valinc achydride)ݼperlolyrine)ܺӣणuracil)װtrimethylamine-HCL)Ȼchloine chloride)ᣨpalmitic acid)ȩvanillin)1--β-1-acetyl-β-carbo-line)[10]Ҷϩspathulenol)β-޴β-sitosterol)ᣨlinoleic acid)dilinoyl palmitoyl glyceride)ǣsucrose)[11]

ҩá1.ϵͳ ܺԵáܺӷʱԶԵĻãԺࡢѪ˶༰跴˷áֱܺСigԷʹͱС˯ʱӳܶԿ20mg/kg˷áܶԿĵµĴʡôܺ25-50g/kgθƴԷС򾲽ϴԣӳͱ׵˯ʱ䣬׿˷ܣҲֹܷϩĵ򡢿ɿľʻáձܺĻӷͲֶԶԵĻãԵѪ˶ࡢ༰跴˷ãӴתΪơ

2.Ѫϵͳ2.1 ܺܺ࣬Ũ1O-5-10-4ʱʹEnglmannϷ飬ܺ2030g/kgigҲʹλʼ40g/kgigʹͣܺivȮҲǿãʼӿ졣ȥ񾭵࣬ԴܺԷӦ׵עϴܺຣѪòԡԤȸĵðѪƽȫܺຶã˴ܺຶãͨ񾭼˷B¡Ȯעܺ124mg/kg.ӣ,10,ʼӿ,ļǿ,ѪšЩmm10ӣʼӿ죬ļǿѪšЩӶǿעlmg/kgӣʱʡLVPdp/dtmaxӣ2mg/kg.ӣʱʡLVPdp/dtmaxѪӡ4mg/kg.ӣʱָ⣬LVEDPCIļĺѪӣ״Ѫ͡ѸѪѹȮעܺ4mg/kg.ӣ1iv20mg/kgҲʼ١ĵðivl-2mg/kgܶԿܺຶȮЩãѪƽȫԿܺີáбܺຶļӹڶIvܺ10mg/kg1-5ļȡCBFIvܺ5mg/kg5ʱCBF14±15ml/ӣʹÿ100gļ1.0±0.7ml/ӣ塣Ȯivܺ10mg/kgɽѪѹLVSP±LVdp/dtmaxļܺivÿʹȱѪļٹעˣÿѪӹļģļлйءܺ150mg/kgڼig15Ӻiv´ҶأPit1.5λ/kg30sע꣩ivPitձļȱѪ,ĵͼΪTֵߡҩT̶߳Եڶ,зdzԵĶԿPitļļȱѪȱá

2.2Թѭ ܺˮҺŹ״ѪܣӹѪļȱ״Ȯiv຺ܺ󣬹Ѫ࣬Ѫܼܺ͡ҲӴͷѪͬλ86RbʾٷִܺҲСĹѪʾܸļлӶļȱѪ֢״ܺivҩﶯѧоܺҪֲѪḻĴѭ֯Ѫƽн⾷ãٻȻѪܾлãԽȮͷζѹܺ຿ŽζȥصķӦԣŷζʼϵٽζϳͷPGI2ʹƴܺŷζٽPGI2ϳͷŵá÷ѪСۼⶨܺຶѪƤϸӰ졣ܺʹƤϸPGI2ߵá133xe뷨ⶨܺԵӼѪáҩ10ӣѪԼӣҴ԰ֱ112.19%124.72%ѪýڼǿʱϳܺipС󣬲ͬʱڶԹѪһãҩ10ʹļȡ86Rbӣ15ʱֵַP0.00130ʱȡ½߼飨30mg/kgȵͼ飨15mg/kgøԣʱҲϳͬʱ30mg/kgڸҩ15ʱļȡʱ18.11%P0.05ܺԹѪŵá

2.3ѪѪѹ ܺܺʹܺʹȮѪ½ʹԡɶ֫ѪӡܺԲֺʹܺȻضԼáܺࡢˮҺҴˮҺҴҺȮèõimivŶ־õĽѹáˮҺ͸ѪѹȮigԽѹáȮ״ivܺƼʹѪͣѪѹ½ivܺ຿ɼϵĤ΢ѭѪٶȺ΢ѪܿĿӡܺຶԽƵȥɵ΢ѭϰڿھ١ëϸȷԸƣж΢ԡ3Hʾ٣Сβivע룬8ʱ3H-ܺ຿ɽ϶͸Ѫϣﵽ߷壬ǴܺີҪ֮һܺ20mg/kgʹèѪѹͣP0.0140mg/kgɽѪѹļԡ80mg/kgʹѪѹ½๦֣ʧԲͬҩ;ͬĴܺຣԸֶèúʹ󣩾ɲ̶ͬȵĽѹá併ѹ첫ƣֱѪĽѹáivܺɼȱµķζѹӦѹ仯ٶȣ±dp/dtmaxӰ죬ʾŷѪܣܱ๦ܣһֿȱԷζѹҩʧѪݿ˼עĴܺຣʹѪӣӷΡСĸɡʪرȱѪҺ֯Լ٣ʾܸܺѪ״ѪѹܺˮܽͶѪѹýȮèãע䣬ѹýԣעѹӷͲ޽ѹãȡöݣˮŶ־áУ͸ѪѹȮγ2º󣩼󣬴ܺˮڷ4//գʹѪѹ20mmҡԿ͸Ѫѹ󣬴ܺˮнѹãѪѹϿ죻ȮԭԸѪѹЧγ͸Ѫѹ1ҵȮôܺѹòԣɼǿѪƽ0.005-0.01mg/ĽѹãѪƽļС0.003mg/ֳܱܺǿáձܺӷͶ΢ԣΧѪֱá

2.4ѪСۼѪ˨γɺѪҺճͶȵӰ ܺӳADPյѪСʱ䣬ѾۼѪСнáܺӰѪС幦ܼѪ˨γɿͨTXA2/PGI2֮ƽ⣬ܺTXA2ĺϳɣڸѪСѪУ봨຺ܺTXA2ѪСۼܵơͨ䱡ɨ衢ӰͷⶨܺҪTXA2ϳøóЧϵԽԽǿԿTXA2ʵĻԣƻϩᡢѪøյѪСȩɣԻøԺPGI2Ӱ죬ǿPGI2ʶԼѪСۼáӦø߲ⶨⶨⶨ˼ʵȱѪȱѪǰѪB-Ѫ˨򵰰ףB-TGѪС4PF4Ѫ˨B2TXB26-ͪ-ǰF1a6-ͪ-PGF1aı仯ȱѪѪB-TGPF4B2ͺߣP0.016-ͪPGF1aĺԱ仯ivܺעҺ1.0ml൱ҩ0.2gÿ1Σ14գԵѪB-TGPF4TXB2ı仯P0.01ʹѪ6-ͪ-PGF1aĺߣP0.05ʾܺЧȱѪʱѪСļѭѪTXA2-PGI2ƽʧܺʹѪСAMP߽1ӶѪСۼѪСͷŷӦϸĤϵĸƱãʹѪСCa2+ŨȽͣCa2+ѪС弤PGлʾܺƸ׿ڶϸУ֬֬PI֬-4-ᣨPIP֬-45-ᣨPIP23֣ҪϸĤϡPIPIø߻¿ɷữPIPPIPø½һữPIP2ĿǰѹPIP2ǼᣨIP312-ͣDGڶʹǰ壬PIP2ˮƽĽͣؽӰڶʹIJӶӰϢĴݡIP3DGЭͬÿɵѪСķۼ֪ѪС20KǼ򵰰˶ĵữɴٽ򵰰׾ۺϣ뼡΢˿ϣӶѪСۼܺܽѪСPIP2ˮƽ20KữŨȣIC50ֱΪ40umol/L110umol/LܺҩйءܺijЩѪ˨ԼһЧΪѪСѪ˨γɹϵС԰ϸѪ˨γеܵӡбѪøյܰϸۼõ羵۲쵽Ѫ˨ԼѪҺдڰϸ-ѪСۼ塣ʵѪø𵥸ϸ-ѪСۼʾϸѪСһѪ˨γŲɺӵáʵ黹ܺຶѪøյĵϸ-ѪСۼнǿãʼЧӦϵ顢ͪAѪСۼƼѪøյĵϸ-ѪСۼӰ죬ʾܺີþһԡǵѪøյĵϸ-ѪСۼһCa2+Թ̣ܺ຾Ca2+ͨã˴ܺǷͨCa2+ϸֵÿоƷİκԵĿѪСۼãivADPͽԭշѪСۼκỹѪСTXA2ͷţֱӵ׿ãӰ춯PGI2ɣҶPGI2ǿáκʹѪСcAMPߣӶѪСۼöԵ0.4%ܺ2mg/kgԽȫѪճȣWBV͸ƺϸıԣEDEDĸƿϸĤйأϸڵĴлйϵܺߺϸѪСɣѪճճȣѪҺáִܺøãֱӼøԭܻԡܺʹСѪcAMPߣܵӰϸлܵá

3.ƽ ܺ10%ˮҺӹ΢ʱܴ̼ӹʹߣǿճʹӹԶֹͣôܺעͼḁ̃лӹУ׹£̥еĻڶӹܴܺӰ̥Ӫ¡ܺСûСʹСȫֹͣܺİκԳɷ֣?-Lactoneƽпáܺκἰܺн⾷ã޻ǽ⾷Ҫɷ֡ip0.14ml/kg޻ܻ鰷´ӦԼ50mg/kg¡iv޻Խ鰷ԼȻƽܺȱķѪػȻѪҲá֯ϸԴܺûƱܺຶƽɳЧӦ첫ͣԷdzƣƲ⴨ܺ຿Ϊһµĸ׿ܺig300mg/kgСʹãձȽP0.001

4.õ ܺԴ󳦡ϣΡŧ˺˺˾һáܺˮ1:3ԹڶijЩ²ƤҲá

5. ܺԶ䲡ʵһЧܺˮԴƼԴСȮķ뵪˾бáܺԴĿЧСãipimҩЧãimҩigЧá

6. ܺõѪ򡣴ܺDNAϳɣʾƵʺͿɡܺijЩάEȱ֢ãܱάEȱӪԲκƿɼH2O2O2֬ʹӦпOHȩMDAѪáκƿԽͲѪƲ3bC36ϸĤĽϡܺຶƽùڸҩƱСάá

ԡԣܺ຾עСLD50Ϊ239mg/kgܺˮԴƼСipimLD50ֱΪ65.8666.42g/kgܺСivLD50Ϊ239mg/kgСÿpoܺ510mg/kg4ܣءѪ󡢸ΡܺͲ֯ѧδ쳣

1ȡĩ1gʯѣ30-60ml10hʱʱҡãȡҺ1mlӸɺ󣬲Ӽ״1mlʹܣټ2%35-ļ״Һ2-3صļ״Һ2ΣԺɫ鲻ࣩ2ȡĩ0.5g1h˹ҺŨ1ml7%ǰ״Һ2-3Ρ20%ѴҺ3Σˮԡ΢ȣȴ󣬼ϡPh3-4ټ1%ȻѴҺ1-2ΣѲ洦Ϻɫ㶹ࣩ3ȡĩ0.5gˮ10mlҹ˹1%ԣȡҺ1ml3ݣֱӵ⻯ء⻯غ͹Լֱٺɫɫɫ

4ȡƬ¹۲죬ɫӫ⣬Ƥ԰ɫӫ⡣

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