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2017-06-14 11:46 Ķ:

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ӢPHERETIMA

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ԴƷΪƶλëPheretima aspergillum E. Perrierͨ׻ëPheretima vulgaris ChenëPheretima guillelmi MichaelsenäëPheretima pectinifera Michaelsen ǰһϰ“”ϰ“”^׽ļ׽ʱʿȥ༰ɳϴɹɻ¸

״ʳ״ƬԵԾ1520cm12cmȫ߻ڣغɫϻɫdzɫ1416Ϊֳϰ“׾”ϹǰԼ⣬β˶ԲëȦֲڶӲɫdzֳڵ18ڸëȦһСͻϣԵƵdzƤޣڲëȦ¡ǰкţһŻţСͻÿ1020ȡܾҿ2ԣλ7/88/9ڼһԲͻϣԼռ5/11ᣬԳʸʣ۶ϡȣζ΢̡

815cm,0.51.5cmȫ߻ڣغɫƺɫdzɫܾҿ3ԣ6/78/9ڼ䡣1416ΪֳϹ18һֳסͨ׻ë۽ǻȫʻ״״ë۽ǻ׳ѷ״äëֳڲ1Сͻ

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Ρȶͨ磬ƽڸ裬鴤ؽڱʹ֫ľ죬ȴȣˮףѪѹ

÷4.59g

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򾡢OPPπޡ򾡢򾡢π󵡢ӡπ

ԴҩĻԴΪƶλëë򾡢ͨȻë򾡢äëȵȫ塣ǰһҩϰ“”ҩϰ“”

ֲﶯ1.Pheretima aspergillum(E.Perrier)2.Pheretima guillelmi(Michaelsen)3.Pheretima vulgaris Clen 4.Pheretima pectinifera Michaelsen

պʹأ^׽ϴȥճҺʱʿϴȥ༰ɳɹɻ¸

ԭ̬1.λë򾣬ϴ󣬳110-380mm5-12mm屳ɫԵǰ˽ϼ⣬˽ԲԲΡͷ˻λǰˡȫ100ɡÿһëëȦ԰ס14-16ڽṹ⣬γɻ޸ëֳ1λڵ14ڸУֳҲ1λڵ18ڸܾ࣬ҿ3λ6-77-88-9ڼ䡣 2.ë򾣬峤96-150mm5-8mmɫɫdzɫռ14-16ڣ޸ëϸëϸǰ˸沢ֶ衣ֳ18һdzǻڣʱѷ죬ڱ壬иë2-3ǻͻΪۿףͻǰͨпͷͻܾҿ3ԣ6-77-88-9ڼ䣬һеСͻϣܾǻ8-99-10ڼȱĤä򵥡ܾҵäڶ2/3ƽϣΪɾҡ 3.ͨ׻ë򾣬СɫڲëơΨܾǻ㣬ǰԵ¡ףɼǻڴСͻһ۽ǻ㣬ڱڶƣƽͻ3λǻףһͻΪۿڴȫһ

4.äë򾣬峤100-150mm5-9mm漰ɫϺɫëȦףռ3ڣ޸ëǰë֣2-9ڲֳ֡һʮͻ룬һdz״Ƥ޸סڲһͷб仯ܴܾҿ3ԣλ6-77-88-9ڼ䣬λüܵһ룬һͷĺ࣬ǰƤ״󣬿׳룬׵ڲูڸëȦǰͷͻнϹ8-99-10ڼȱĤäʽ丹״Сҡ״̹ܡäܾܽұ峤ڶ3/4Դֱ֣

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1.ڳʪ֮У˳ٻ
2.ڳʪлﴦ
3.ڳʪлﴦ
4.ڳʪлﴦ

Դֲ
1.ֲڸ㶫ȵء
2.ֲڽա㽭Ϻȵء
3.ֲڽա㽭Ϻȵء
4.ֲڽϲ㽭Ϻϲȵء

ࡿϰ ΪҹԶһϢڳʪУ10-20cmϲʪʪϲ¹⣬Σµζǿ˱жܹ֮µ֯涪ʧIJ֣µ5ʱжߡʳԣʳԹ㷺޶ĸֲᆬҶ㼰лȾáΪͬ嶯彻䣬Լ1ڲѣڼڣÿںܾ3-42ҷ򾡣 ֳ ֳҪߣ÷͸лͲ԰Ȼ϶ɡҪˮ30%ңpH6.8-7.6ΪˡιлĽոˡҶݷ辭ʹ󣬲ܱáֳܶȲɹ¶21-25Ϊʲ¶ȡ 2-3ºҪÿɸշη෨Ƚࡢ뼰ֿ

״״ 1ʳ״ƬԵԾ15-20cm1-2cmȫ߻ڣغɫϻɫdzɫ14-16Ϊֳϰ“׾”ϹǰԼ⣬β˶ԲëȦֲڶӲɫdzֳڵ18ڸëȦһСͻϣԵȦƵdzƤޣڲëȦ¡ǰкţһŻţСͻÿ10-20ȡܾҿ3ԣλ6-9ڼһԲͻϣԼռ5/11ᣬԳʸʣ۶ϡȣζ΢̡28-15cm 0.5-1.5cmȫ߻ڣغɫƺɫdzɫܾҿ3ԣ6-77-88-9ڼ䡣14-16ΪֳϹ181ֳסͨȻë۽ǻ׳ѷ״äëֳڲ1Сͻ ΢ λë򾣩ĩɫһɫбƼάɫɫάɢ໥ƽʽᣬƽֱֱ4-36-66μmԵ룬еľֲԡڱƤ̻ɫϸ޲ԣаɫɫؿɢڻۼ״״۸ëټɢڣɫɫвֱ34-63μmȶ˶ԲɼơƷʱ־ л񹲺͹ҩ䡷1995涨Ʒؽù֮ʮȽⶨˮﲻ16.0%

ѧɷ֡λëͱ촽򾺬Ѫɷ֣أlumbritinȳɷ֣ȼlumbrofebinжɷ֣򾶾أterrestro-lumbrilysinȡ6-ǻʣ hypoxanthineʣxanthineʣadenineʣguanineңguanidinecholineԼᣨalanineӰᣨvalineᣨleucineᣨphenylalanineҰᣨtyrosineᣨlysineȰᡣҹ۵ijӰʤ򾼴ɫʤӽ֣Ϊ“ƽ”к춬ᣨaspartic acidհᣨthreonine˿ᣨserineȰᣨglutamic acidʰᣨglycineᣬӰᣬᣨmethionineᣨisoleucineᣬҰᣬᣬᣬ鰱ᣨhistidineᣨarginineᣨprolineпͭ⡢þԪءӳӰҳѪСӣplatelet activating factorǰ1-O--2--sn--3-ᵨ1-O-alkyl-2-acyl-sn-glycerophosphocholineռ֬phosphatidylcholineıߴ61.4%

ҩá1˨Ϳ λëǻҺɴֱַעʮָ30mg/kgԶܴճά׷άɣԵά׻ԣлɺԼɥʧάƽⶨ֤ɴַ5μgø1uά׻൱άƽ徭85ˮԡ30minøĻɥʧɴַ۵ĻԲֱ˵ɴַά׻øȫһøǼάøԭʹ֮ΪлԵҺ߻άܽ⣬򾶳ɴַ۳ø⣬ֱӴ߻άˮáӰʤȡҺþѪ˨ܽã̵ά׽ҲһܻԡֱάܽͼøԭļãֱΪþעˮҺ0.lg/kg0.2g/kgԾܶһ⾲Ѫ·ʵѪ˨γã1g/kgƣע0.02g/kg˨áþעLumbricus kangtang6nsisȡעҺÿ 1mlҩ 2g2ml/kgӳѪСѪ˨άѪ˨γʱ䣬ʹѪ˨Ⱥ͸ؼ٣ѪҺճȡþע˹ֳ˫Lumbricche bimastosȡҺŽѪάԭʹ򵰰ܽʱ̡ȡҺһȡƱøøԭƼõܽѪ˨ãʹѪ֯øԭt-PAӣѪСۼŽͣȫѪճȺѪճȽͣϸָͣʾͨٽܡѪСۼǿϸĤȶԵȷáɷˮҺԼά׺Ѫܽáþעˮ崼עҺԶԵѪ˨ܽá־Ը߿ڷȡԵĿãءѪøʱӳøԭǿ򵰰ܽʱ̼ά׽ﺬӡȡøɷۣùθ0.05g/kg·d 0.1g/kg·d3dȡѪγɵѪ˨ȡʪءؾ϶Լ١

ţѪøٽѪάԭԿѪøáӰʤȡѪøʱ䣨TTӳãȱѪø-IIIAT-IIIѪмȡҲʹTTӳӳ̶ȽС˵AT-IIIͲAT-III֡þעȡEEӳTT˥0.32hEEӳTTͰѪøʱ䣨KPTTˮҺӼˮҴּ룬ȡӳKPTTTT俹ѪøԲܱAT-III弰㾫кͣԲAT-III ûԳɷֲǻ򵰰ʣһͼȵСĻ˫ϣˮءصȿʲͬ ѪճۺȱѪз综ÿڿڷӰʤȡҺ14dΪƳ̣12Ƴ̣ߵѪϸȡѪѪճȡѪάԭȾн͡þעȡҺʹѪСۼŽͣȫѪճȺѪճȽͣϸָ͡ 2Ѫϵͳ 1ʧøᄇעעҺȷһػͷշĴʧȻëGշļʧԵĶԿãഫá

2ѪѹȮעˮҴҺ0.1g/kg3045minѪѹ½ά2һ3hιθ10g/kg͸Ѫѹÿ׼θС50mg/kg2ڣԵĽѹá͸ѪѹѪѹ½ڸҩ37dͣҩ2ڻҩǰˮƽĽѹƿֱڼϵϵͳͨijЩڸӰϵͳ𲿷ѪܵŶʹѪѹ½0.25g/kgѪѹ½併ѹѪСӣPAFƣԤȾעPAFͼCV6209ƹĽѹãʾPAFǹҪѹɷ֡ԷԸѪѹSHRSPιʳϣڲӰSHPSPص½SHRSPѪѹѪܵԼʪرȣg/ʪmgͶʱ󸺺ɣg/ʪmgرȣļmg/g ×10-3رȣһơͽãʾһԤSHRSPзá

3ϵͳâȱѪУз磩ԤȸǻעעҺ10g/kgɹɳһԤܶɵȱѪоһԤãɼȱѪе֢״ëתȦΪʹȵķ½ԽͶʣʹȱѪж֯н˵ĵ5һɫͶͰڻָȥغӰ졣ڿʺãСǻעǦȡҺԶԿĵͿľʣܶԿľʣʾ俹òλڼϵ񾭲λСǻעҴҺ20g/kgԵ羪ҲжԿãEDΪ22.18g/kgҺС󡢼á۽ãˮԴ󳦸˾ڶؼȴ̼ķȼþõĽãϰֵڷɢ 12gԽ޽ãԸȾԷȻ߽ڰ˾ƥ֣ڷ0.3gԷǸȾԷЧóֽһڷԼ0.5-3hЧ2-5h½ 4 Сÿչȡl1mg/ֻ58dֲS180ԵãԼ٣ҿӳСڡСÿչȡ1mg/ֻ6dֲʵH22Ҳáȡᆳ͸͸ҺԽS180ʵEMT6Сãóɷ־10020minְüʧ͸θϸMGC803˱ H3TdRã־560.5hȻڣЧַӽСȡӦ˼Եȡз 4֡Iθϸ MGC8033HTdRзdzŵã־560.5hԴڣδԼʾּȺòֱһԡIVθϸMGC8033HTdRҲзdzŵã־560.5hüʧʾֲȣIIIIIáȡĺϸ Hep2ŨáСȡ5һߣ5FUӦöٰMAЭͬãȵ5FUӳ3dϸԻϵأСʱҲϵӳšȡ׽2IL2ӦöСS180ЭͬáֲS180Сȡ5FUӦʱЭͬãЧAK123ӦǿķЧãߺЧá⣬ȡAK123ö˺ϸHep-2ҲЭͬáȡӦöСʵ EMT6ҲЭͬá

ȡS180СдٽƢܰϸתãԸֱߵӼδСƢܰϸתҲдٽãʵСƢܰϸѪܰϸתáʾȡͨ߻ϸġСǻעȡ100mg/kg6dʹټƢкϸӣƢϸԵ򵰰AConA֬ǣLPSķӦԾԸڶ飬ƢȻɱϸNKϸ鵼ϸADCCҲŸڶ顣ԺС߹ãƢNKAfXICŵڶ顣СXƻֲƢءƢкϸNKϸԡADCCԼϸIL2ԾܵһƣõȡҺƣδκãߣʾԻ߹ܶһĴٽáСÿչȡʹβѪϸѧǿʾǿɹܣS180СNKϸ½ȡ8dNKԻָ߷õȡ2£ϵпܰϸȺ¡壨McAbüӫⷨT3T4T8T4/T8TbTacBϸȺֵȡ߿T3T4T4/T8ʾΪһǿܷƵʳܰ۵ȡ150mgÿ2Σܿƻ߰ϸ½Чǿ̶࿹أpolyactin AS180Сÿչȡ100mg/kg7dʹӫֱӷӳ֬ʹʣͣѪйŸĻԭøGRøCATŸĹøGSH-Pxͳ绯øSODĻӣʾȡɻ֬ʹáȴ֤ȡ뼤⡢ѪҶS180ϸЭͬɱãѧǿҲߣ罫ɻCATSODڣʹǿķǿԼСʾȡЭͬٲͨӻʵֵġ

5ƽǻעҺÿ1mlʵԼ0.75g/ml2mlѵĹDZӳ鰷DZҲӳᵨӰ졣ǻעҺ2ml3dѵıƤӦá⣬Һ8×10-7g/mlŨȶ鰷áĺɷֶԴ󡢼÷ιע֧ãܶԿ鰷ë֧ע50%鰷Ϊijֿ鰷壬Կ鰷ʹܾμëϸѪͨ͸ԵãΪƽҪơ

6ƽôӹȡĵɫᾧʹкδдӹŶߣŨӿʹ֮ʾ״̬ע1mg/kgʹλӹŶߣע 36mg/kg 1020mgl/kgʹӹܼӹǿ⣬ýᾧ0.5 1mg/kgעԼλ˷ãԴ֫Ѫܹ˷ܣ֧ý

73%ȡ2.5%ȡ

84%Ҵʯȡͽ˸˾нǿã3%ȡͽ˸˾ϡλֱΪ100ż702.5%ȡϡͱΪ100ȡȣ 84%ҴȡϡͱΪ3200ȡ

ȡС˵ľӾпɱãеᡢ͸Ѹʹƶʹṹܵƻ

ȡҺöԾӲƤЧȡԽ⽺ԭάĽԭøЧܿǾֲԽԭά¡

8ڹ̼þעαëעҺѪøʱⶨΪҩЧָ꣬ҩЧһϵҩѧ俹ѪøЧɷһѧ϶ģͣt1/2aΪ4.1limnt1/2βΪ140minЧAUCΪ169.1mg/kg·hʣCLΪ0.964h1ʾѪøɷѪҺֲ֯ʺܿ죬һСʣڷֲ㷺

9ԹȽСעLD50Ϊ3.85g/kgǻעLD50Ϊ95-115gl/kgθ0.lgl/kg·d45dδֶԷӦСǻעעҺLD50Ϊ40.7g/kgӹ 1000gõɫᾧ 2gСΪע LD50Ϊ 38.7mg/kgQʷλë򾶾ֵҩѧһѧһģͣt1/2Ϊ31.2minΪѪøɷ˥ڵ22.3%ְ˥ڶ̣ԵҩжȽϰȫ

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ΡֹƽϨ磻ͨ磻ƽȲȿ鴤ͷʹзƫ̱ʪʹȴȣС㲻ͨ

÷ڷ5-10gĩÿ1-2g衢ɢƷǻλˮãƷ÷ȡ֭ͿĩͿ

ע⡿Ƣθ麮˷и

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