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2017-06-13 16:25 : Ķ:

йҩ䡷

ҩơ

ƴDà Zo

ԴƷΪֲZiziphus jujuba Mill. var. inermis Bunge Rehd. ĸʵ^ʵʱգɹɡƤҩʱɲɡ

״ƷԲλΣ23.5cmֱ1.52.5cm氵ɫԴвơݣж̹ƤйƤػɫ򵭺ɫʣԶ󡣹˷ĴΣ⣬ʼӲ΢㣬ζ

ȡƷĩ2gʯѣ6090棩10ml10ӣԼ10ӣ˹ȥʯҺҩɣ20ml1СʱԼ15ӣ˹ҺŨ2mlΪƷҺȡչƷҴƳÿ1ml1mgҺΪƷҺձɫ׷¼ B飬ȡƷҺ10μlƷҺ3μlֱͬһ轺GϣԼױ--ᣨ14:4:0.5Ϊչչȡɣ10ҴҺߵɫƷɫУƷɫӦλϣͬɫİߵ㡣

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Ρ棩ѪƢʳ٣磬ꡣ

ƤףֹѪֹкףף©˳Ѫ

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ءøﴦ

ժ¼йҩ䡷

½ͼƬ
½ͼƬ

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ƴDà Zo

桢桢

ԴZiziphus jujuba Mill. var. inermis Bunge Rehd. ĸʵƤҩ^ʵʱգɹɡƤʱɲɡ

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Ρ棩ƢİƢйкļ£ʧߣѪС񰡣

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÷ƤΪ23ǮƤȡƳƤƬÿη12Ƭÿշ2Ρ

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ҩǵ䡷

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ƴDà Zo

桢棬棨¼棨ҽѧš

ԴΪֲʵ ^ʵʱաʣɹɡƤɹɡˮһʹƤδʱɹɡ

ԭ̬棨ʫ档

ҶľСľ߿ɴ10ס֦ƽë߳ɶԵֱ̣֦״Ҷ"֮"ۡҶԲ״ΣΣ26ףȶ˶̼ۣбԵϸݣ3ԻԡСΣɶ̾ɡ򣬴ҶҸɫ5ѣϲʻ״²Ͳ״ɫ55뻨ӷ2ңͻڻ룬ȶ2ѣ˹ԲΣ155ףʱɫζ𣬺⡣45¡79¡

ֲһΪࡣֲȫءȫ󲿷ֵвںӱϡɽĴݵȵء

״ʵԳԲλԲΣԼ235ףֱԼ1525ס氵ɫвƣʵһѣоһϸĹһһСͻ㡣ƤйƤ纣״ɫ˷ĴΣӲ˼񣬱氵ɫ΢ζɫ졢񡢱СζΪѡ

ѧɷ֡߰񡢢򡢢ziziphussaponin 񣬢򣬢󣩡߰Bjujuboside BǧټstepharineǡǡǡգcAMPգcGMPȡ

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ΡƢθ򣬵Ӫҩθʳ٣Ƣ磬ѪҺ㣬Ӫͣļ硣ꡣ

١"ĸаƢʮƽθͨϣٽҺв㣬󾪣֫أͰҩ"

ڡݾע"ɷͷ"

ۡ¼"ǿƣƧݡ"

ܡҩԡ"ɱӡ۶"

ڷ"ҺϴĸаͰҩͨϣʳθһСʳ"

ޡջӱݡ"ķΣֹԡ࣬𣬳θѢ"

ߡҡ"θ"

꽣"ԲƢ㣬ԻѪӪҺ"

ᡶҩƷ塷"ѪΡ"

⡶¡"ůθ顣"

ϡйҩֲͼ"ιϰ߲ƶѪѪѹ"

÷ڷ36Ǯ衣ãˮϴմĩ

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١ҽѧš"ƦŻ߼֮ʳ磬Ƣܲ"

ڡݾϡ"СᲡʳ̵߲ʳ"

ۡݻԡ"θʹߣ׽ḹʹһΪߣ̼֮"

ܡϢʳס"ʳйȿʣˡСȡʪǰ󣬻㡢Ͳ֮"

Ƣθʪʳ٣йкȲɽڽҩζڽߣÿζϸ죬ٽɽϸ⣬ͬ࣬Сľ̿˸ɣʱģϸ֮ҽѧв¼Ƣ

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з羪£֫أöȥˣ׶ϡ϶ζˮ룬ȡһ룬ȥңͶʳ֮ʥ¼ࣩ

θ꣬ϲˣޣǷ죺ʮöʲСһζˮȡ·Ҫԡ

οȣһٶʮöȥƤ⣬һöɣʮöȥˣζ̨࣬Ӻˣߡ˶ȣڷЧ

ܾ졢ꪸȷ֡ζɸˮһϣʴʮöȡ˺ϣȥҩĩǿ˷һǮذ˷Ǯذƽ·֮ߣոӰǮÿ֮Ҫԡʮ

ͷƲߣʮöа߾϶ζˮһȥҶٷǧ𷽡

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ηѪС񣣺棬ÿΣÿ10ֻȫΪֹһÿԼһϺҽҩ4221962

᣺棨ȥˡʯգưءͬΪĩϷ

òˮȡһ룬ϴȡǧ𷽡

ηۣʮȥˣĩ֣⵷ɸ࣬ʪֽж̣ȡȥֽˮ룬ȥϴۡݻԡۿƷ

ٴӦáԤѪӦ

Ѫǰ1530ӷ20öطӡ3Ǯ46˴ι۲죬޷Ӧռ23ңҺٳ֢°ӦԼδֹܷӦIJЧ

ڽѪȱתøˮƽ ڼԸסӲߵѪתøϸߵIJˣÿ˯ǰ滨桢Ǹ1ȼ廨Ӻǣ130ΪһƳ̣۲12ЧԺϲȾʪϲļ׵IJˣӦʪҩ

עӹIJͬк桢֮֡ҩһԺΪ

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ӢChinese Date, Jujube

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ԡũݾ

ԴҩĻԴΪֲĹʵ

ֲﶯZiziphus jujuba Mill.

պʹأ^ʵʱգһɡɹѡĵؿϯֱּ̯ϯɹĺˮ½15ʱɲȻÿսҿͨ磬ĺˮ½10ʱءƤˮֶ࣬ɵķƸɡѡƷ֣ӹɺ档

ԭ̬ ҶľСľߴ10mг֦֦֦֦ƽë֦ϸԳ“֮”ϺɫҺɫ2Ҷ̣̿ɴ3cm̴ֱ䣬4-6mm̴֦֣Բ״֦С֦ɫ´2-7ڶ֦ϡҶֽʣҶ1-6mm֦ϵĿɴ1cmҶƬΡ״ԲΣ3-7cm2-4cmȶ˶ԲԲΣСͷƫбԲΣԵϸݣɫëdzɫëëɫԣ2-8ҶҸɾɡ5ѣƬ״Σ5ԲΣצ5뻨ڻ̱Ե̺ʣԲΣ5ѣӷ2ң뻨̺2ѡ˹ԲλԲΣ2-3.5cmֱ1.5-2cmʱɫɫйƤʡζ𣬺⡣ӱԲΣԼ1cm5-7£8-9¡

ֲ̬ں1700mµɽƽԭȫعΪ࣬Ʒࡣ

Դֲԭҹޡŷޡ޳ֲ

ࡿѧ ϲϲ⡢ͺͺμ-31.3ĵ£Ҳ39.3ĸ¡ɽ¡ꡢĵءƽԭ·Ծֲɰ࣬ڵˮԵء

༼ ӡ꼰޽ӷֳӷֳֵ뾭ɳشڽⶳ֣ﲥ10ѮСо33cm7-10cmÿ7-10cm12-3cmˮʪ귱ֳ֦֡޽ӵϿ죬̽٣硣ΪľѿӡнӡƤ½ӡӵȷ1-2꼴ɶֲڴѿǰ^ҶУɽµֲӦۿӡС̨ˮƽΪ3m×3mµ5m×4m6m×5mֲѨֱΪ80-100cmÿѨʩ25-50kgֲˮ

ȶڣչҶھӦˮһ㶬ʩʣѷʡǷʡǷ۵ȣڿǰÿʩ李0.5-1kgʵиݡ԰밫绨ࡢ

溦 財Գвƽֲ꣬ʩлϣֲ漴γصĴҲӦڳȫյ溦в棨󶣩Сʳij桢ճ桢̶꣨ӣҶʭȡѡƷ⣬ɲùƤɸ롢԰Ӳݺв֦ҶȷҶʭڷѿǰ3-5ʯϼ

״״ ʵԲλΣ2-3.5cmֱ1.5-2.5cm氵ɫԴвơݣж̹ƤйƤػɫ򵭺ɫʣԶ󡣹˷ĴΣ⣬ʼӲ΢㣬ζ

΢ 棺ƤΪ1бƤϸǻغɫʲп״ⱻ5-7.5μmĽʲ㣻ڲΪ4-6ϸںɫ͸ſ״йƤԲαϸɣϸ϶ɢвϸСάϸ״ſͲƷ徧

ѧɷ֡1ʵǧټstephar-ineN-ȥ׻ҶN-nornuciferineżasmilobine

ֺ໯֬ͪᣨbetulonic acidչᣨoleanoic acid˹ᣨmaslinic acidɽᣨcratagolicacid3-O-ʽ-㶹˹ᣨ3-O-trans-p-coumaroyl-maslinic acid3-O-˳ʽ㶹˹ᣨ3-O-cis-p-coumaroyl-maslinic acid֬ᣨbetulinic acidᣨalphitolic acid3-O-ʽ㶹ᣨ3-O-trans-p-coumaroyl alphi-tolic acid3-O-˳ʽ-㶹ᣨ3-O-cis-P-coumaroylal-phitolic acidʽ໯ʽzizyphus saponin񡢢򡢢߰jujubosideBϻ߰cyclic adenosine 35’-monophasphate cAMPͻ߰cyclic guanosine 35’-monophosphatecGMP֣ʵˮԽкǣfructoseǣglucoseǣsucroseǺǵĵ;ǼİǼȩǣʵҪ֬ᣨoleic acid޴й޴sitosterol޴stigmasterol޴desmosterolлܿ߰rutinɴ3 385mg/100gά C 540-972mg/100gԼ˻أri-boflavineأthiamineܲأcaroteneᣨnicotinic acidȡֺʣtannin㶹coumarin deriva-tives֬ࣨlipids֬ࣨresinsƻᣨmalic acidȡ

ʺ߰ABB1ֺᣨindole acetic acid滹ᣨlysine춬ᣨaspartic acid춬asparagineʰᣨglycineȰᣨglutamic acidᣨalanineᣨprolineӰᣨvalineᣨleucineȰͰڵ36΢Ԫء

2޴ʵ߰໯޴߰zizybeoside񼰢޴´߰zizyvoside񼰢򣬳߰roseosideɷ֣zizyphusin޴daechu-alkaloidAҶnuciferineҩco-claurineԭҶnornuciferinelysicamineֺĻ޴滷-1daechucy-clopeptide-1޴daechuineS3ȡܽľvomifliol68--C--2S-Ƥ[68-di-C-gluco-syl-2S-naringenin]68--C-ǻ-2R-Ƥ[68-di-C-glucosyl-2R-naringeninᣨpalmitoseic acid11-ʮ̼ϩᣨvaccenic acidᣨoleic acidԼ߰޴氢ǣzizyphus-arabinan֬glycolipid֬phospholipidȡ

ҩá1.1.1N-׻-N--N-ңMNNGշθ Wistrarϵ80-120g۴ƼáI飨飩18ֻˮͨɿϡ飨MNNG飩18ֻȡMNNG100ug/ml10moιˮͨɿϡ飨MNNGͬʱ飩16ֻMNNG100ug/mlͬʱ棨ɹÿÿԼ1gmo15ͣҩͬ顣飨MNNG7mo飩125ֻMNNG100ug/m17moºӴ15ֹͬ顣ߣθʮָС󳦡Ρܰͽἰεθһشпȡ0·3-0·4cm֯,̶ھƾҺ֯ƬH.EȾɫۺ;¹۲̬ѧı估θķʡMNNG100ug/mlͬʱ15moιθٰķΪ15.42/13θܵķΪ38.4%5/13MNNG100ug/ml7mo8moͶĢθٰķΪ21.7%5/23θܵķΪ34.8%8/23飨MNNGθķ71.14%10/14ȣP0.05Բ졣˵MNNG󣬳ιҩнθʵá

1.2һ180ֳ Ӵõ໯нһ͡Եľᡢɽᣬҩ7d25mg/գ5-35%һ180ֳЧرɽᣬҩ14գ61%Ч5һFuʸǿ

2.ͱ̬Ӧ2.1ԿIgE̼Ѫȼ԰ϸͷŰϩLTD4 10gˮ100mlȡõȡҺHubscherѪҺзȼ԰ϸLichteinsteinOsler2X10-2嵪/mlĿIgE̼ʱڵڶ1:10ϡ͵ĴȡҺLTD4IJⶨSamuelssonСɼȼ԰ϸδκδ̼ʱLTD4IJ٣Էͷţ2X10-2嵪/mlĿIgE̼ʱɼLTD4ͷšڵڶ1:10ϡ͵ĴȡҺʱLTD4ͷԷͷŴͬcAMP͸ϸĤڻѧͷŵĵڶڣLTD4ͷţƱ̬Ӧйء

2.2IgE Ҵȡеһ-a-߰ethyl?-D-fructofuranoside100mg/kgǻע䣬Դ󱻶ƤӦáûҴȡĹлý,жIgEIJá5-ɫ鰷׿áкеcAMPҲйء⣬беϵ㶹Ļԡ

3.3.1񾭵 ӳΪִָ꣬ڱ״߰ʣ߰ȶֻŽѹãȷʣࣩ߰ܽԷ˶̼ãǿֱľãá

3.2ء С10-20gִ飬18ֻÿ30%0.3ml/kgˮ0.3ml/kgipʵжСֱ׻ϼ߲3wkոʱأƽ3.0gƽ1.6gͬʱ鶯пոӾ飬Ϊ350sΪ230s֤ءǿá

3.3ʵԸβѪ׵׵Ӱ Լ2ֻ2kgȻ̼0·25ml/kgip1ܺԶע1%1ml/kgʱӳһϡ˵ܽͶƵĽⶾã෢Ȳ䡣Ȼ30%ÿιʳǰiplܡʵԼýѪ׵ףֵܵ5·14g%ǰ4.6g%ƺ1wk4.90g%׵3.10%ǰ2.46g%1ܺ3.00g%򵰰2.04g%ֵǰ2.23g%ƺ1.90g%

ԡ̨еSpinosaABΪҩʱֶԷӦ˴ӵֳɷж⣬δԷı

ȡ飬Ҵݹҹ1ȡҺֽϣƣ365nm¹۲죬ɫӫ⡣㶹ࣩ2ȡҺ1ml3̼Һ1mlˮϼ3-5min䣬ټصԼҺϺɫ㶹ࣩ3ȡҺ1mlǰҺ10صļ״ҺʼԣˮԡϼӦȫȴữ1ȻҺȣҺʳȺɫ㶹ࣩ4ȡҺУˮԡŨɣϡܽ⣬˹3֧Թи2mlҺֱ1ε⻯ؼء⻯ءԼԲٺɫɫɫ

ơƣȥʣϴɹɡƣȥпȥ

ζʣ

龭Ƣθ

ΡƢθѪ񣻵ӪҩԡƢθѪ㣻ʳٱ磻뵡ļʧߣꣻӪ

÷ڷ9-15g

ע⡿ʪ̵͡ݲ没ߣˡҽѧšƦŻ߼֮ʳ磬Ƣܲݾ衷СᲡʳ̵߲ʳݻԡθʹߣ׽ḹʹһΪߣ̼֮ϢʳסʳйȿʣˡСȡʪǰ󣬻ƾҡͳ֮

1.ע˺ۡ߹֦ʲݴ֮ʣƢƽʮʤˮ

2.ĿʡΪƢ֮Ƣʳ֮νβҩΪƢѪҩҲ޹Ƶʳݣݺӡ

3.ݻԡԻҩƲѪҺ硢ᡢ裬һ޲̷֮ξ磬㱣־ԣأͣʳζأ,ġƢԪ֤֮ô֮óƤ̵֮

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5.ԭŷô棬Ǻ棬ȡɢҲ벹Ƣҩ棬ȡҲ

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8.ĸаƢʮƽθͨϣٽҺв㣬󾪣֫أͰҩ

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