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2017-05-25 11:05 Ķ:

йҩ䡷

ҩơ

ƴFù Z

Ƭθӡ˳Ƭ׸Ƭ

ԴƷΪëݢֲͷAconitum carmichaeli Debx.ӸļӹƷ6 Ѯ8 Ѯڣȥĸɳϰ“฽”ӹƷ֡

1 ѡ󡢾ȵ฽ӣϴʳõ͵ˮҺйҹټʳΣݣÿȡɹӳɹʱ䣬ֱӱִᾧ˪ʱӲΪֹϰ“θ

2 ȡ฽ӣСֱϴʳõ͵ˮҺգͬҺ͸ģ̳ˮƯгɺԼ0.5cm ƬˮƯõɫҺʹƬȾŨɫȡ桢󣬺ɣɹɻɣϰ“˳Ƭ

3 ѡСȵ฽ӣϴʳõ͵ˮҺգͬҺ͸ģ̳ȥƤгɺԼ0.3cm ƬˮƯȡ͸ɹɣϰ“׸Ƭ

״θӣԲ׶Σ47cmֱ35cmҺɫ˪аݵѿۣΧ״ͻ֧֧ۡأҺɫɼ˪С϶γɲ㻷ƣڲർв롣΢ζ̶飬ࡣ

˳ƬΪƬϿխ1.75cm0.93cm0.20.5cmƤںɫ氵ɫ߹󣬰͸״򵼹Ӳ࣬΢ζ

׸ƬƤưɫ͸Լ0.3cm

ԡƷƻ巨жж֢״ǻȣ飨ָͷʼȫѣģŻ£ƣ룬ѣͫɢƤճɫףͻȻȷ12ϴθ¼̿ˮз£עˮ֢ƣʱʹɲ׵˷ܼעⱣ£Ҫʱ˹ʱƤע䰢Ʒ

ȡ˳Ƭ׸Ƭַ4g30ml백Һ 5mlҡ20ӣ˹Һ÷Һ©У0.25mol/L Һ20mlҡȡȡҺշֹȷ¼ Aⶨ 231nm274nm IJա

ơƬ˳Ƭ׸Ƭֱҩ

ƬȡθӣˮƯÿջˮ23ΣηƯʲݡڶˮ͸ģпڳʱȡȥʲݣڶбƬɹɡÿ 100kgθӣøʲ 5kgڶ10kg

ڸƬȡƬ̷¼ Dɳ΢ɫ

ζʣȣж

龭ġƢ

Ρ棬纮ʪаѣ֫΢ή䣬ĸʹ麮кˮףУʪʹ

÷315g

ע⡿иáġ䡢컨ۡĸ׼ͬá

ءθܱգﴦ˳Ƭ׸Ƭøﴦ

ժ¼йҩ䡷

ư׸ͼƬ
ư׸ͼƬ

ҩǵ䡷

ҩơ

ƴFù Z

ԴΪëݢֲͷƷӸСȡĸԵӸϴΪ฽ӣСֱӹ

θ

ѡȡϴ฽ϴ±ʳεĻҺУÿȡɹӳɹʱ䣬ֱӱִᾧʱӲΪֹ

ں˳Ƭ

ѡȡеȴС฽ӣϴ±ˮҺգ±ˮͬУ̳ˮƯгɺƬٽϡ±ˮҺУǼƳɵĵɫʹƬȾŨɫˮƯڳʱȡ죬ɣɹɡ

۰׸Ƭ

ѡȡС฽ӣϴ±ˮҺգ±ˮͬ͸Ϊȣ̳ȥƤгɱƬˮƯϴڳʱȡ죬ɹɣѬɹɡ

ԭ̬̬"ͷ"

״θӣԲ׶ΣԼ58ףֱԼ34ס˿аݵѿۣΧ״¡ķ֧ϰ""Һɫ˪أҺɫ߲ĽС϶г˪޳ζ̶Ը󡢼ʵ˪Ϊѡ

ں˳ƬڸӣҪڷʲεƬϿխܱ𣬳2.54ף1.52.5ףԼ5סƤںɫڲɫ͸״й󣬲ɼߵĽӲ࣬״޳ζƬȣΪѡ

۰׸ƬƬƬ״˳ƬͬΨȫΪưɫ͸״ƬϱԼ3סζͬ˳ƬƬȡưɫ󡢰͸״Ϊѡ

ϾĴȵء

ԡຬͷ京ͷΪͣòжȴżʡԭ󡢼ʱ̣ҩԵй⣬ҩƷּҲйϵ1ڳ3Ǯ£жжͷͬڴ֫巢飬ģŻ£Ļţ٣겻ԣ鴤ͣĵͼʾԹ粫ʰ-˹ۺжܼʱȣһɻָ⣬1ø겿ӴƤףϵ¡

ơƬȡθӣˮƯÿջˮ23ΣηƯùʲݡڶˮͬ͸пڳΪȣȡȥʲݡڶȥƤΪ꣬ùڼˮԼ2СʱȡɹΣ͸Ƭɹɡÿθ100øʲ5ڶ10

ڸƬȡθϴˮһҹȥƤ꣬ƬټˮڳΪȣȡý13죬Ȼ죬ٱ߳ɸɣ𼱳΢Ϊȣȡ

١׹ۡ"£ӣ壬õӣȥ׼΢ϸƣڵϾһӣһߣһޣȡáߣһľֻľʹȥƤˣУöˮڶҹȻɹá……ÿʮڶˮ"

ڡĿ"ɢߣ֮ȥƤҩߣˮ壬ȥƤ꣬ƬٳƣȥҩַÿһøʲݶǮˮ֭ͯյͬȣһҹ֮ȥҲ"

ۡݱҪ"ˮ壬Ƭƣȥ𶾡"

ζʣȣж

١"ζ¡"

ڡձݡ"᪲׹ʣжϣ࣬ж¡"

ۡ¼"ʣȣд󶾡"

ܡ"ߴ̣Դȣж"

龭ġƢ

١Һݡ"š"

ڡݾ衷"š̫̫"

ۡݾ⡷"ξ̫ξ"

ܡ¡"ġΡ"

Ρ棬ɢʪʢ棬ĸʹƢйˮС纮ʪԣbLΣήҴ©һг֮

1棺нǿ֮áη֫䡢΢֮ѣ˲Σɽʲݣ

2ȣ߶أͨʮʷ֤֮֮ܲ

3ֹʹƷȣǿκа֮θʹйкԼʪ֮ʹ

١"纮аУ𴯣ưYۣѪʪbLϥʹв"

ڡ¼"纮ĸʹתףἡǣǿֶΪҩ"

ۡʰš"׽СָɶУȥȥƤ壬Ϳ֮ڣ֭֮ԡ"

ܡҽѧԴ"Ҫƣȥอ㣬Ƣθ"

꽣"อ棬ʪʹθ׶ξգɢա"

ùţ"ζΪǿʡ"

ߡĿ"˺ޣкз磬̵ʣbСʪԣͷ磬ͷʹкƢйűòŻܣθҭӸҲ©䴯ϴ飬"

ࡶݱҪ"纮ʪ"

ᡶݴ¡"ζҰףһг֤֮"

÷ڷ13Ǯ裬ɢãĩ

ע⡿ʢȼٺи

١ݾע"صΪ֮ʹ򼡣η硢ʲݡΡ˲Ρھ¡󶹡"

ڡƷ㾫Ҫ"ﲻɷ"

ۡĿ"η̶ھ¡ͯѡϬǡ֭ס񽷡ʳΣ´š"

ܡݻԡ"Ȼ֤֮֮ࡣ"

ءθﴦܱձ棻˳Ƭ׸Ƭøﴦ

ȶ񺮣֫мߣʲݶˣɽһ룬һöãȥƤưƬζˮȡһϣȥңٷǿ˿ɴ-öɽ˺ۡ

˺ʢ˱ȶˮߣһöΪңԣΪĩˮرɢ

˺࣬֫棬ʹ䣬һöѣȥƤ꣩ΪĩÿǮ֭յưյůΪȡɢ

˺Ѿת£飬аδ⣬֤޴ȣշ꣬˯ҹŻʣ΢ߣ˷֮αз䣬û̵ˮĸʹתһ麮֮ɽдĩһӣȥƤ꣬ϸУһöϺȡÿǮˮһյ룬һյȥ·ʳǰַ

Ż淭θһһϸﱣ¡鷽

һʹСʹֹߣһڣٺһΪĩΪ裬ɰΪ¡ÿһ裬Ӿ£˴¡ٷɰһ

ޣĸʹߣ׺󸭻йľ㣨𣩰ȥƤӣڣȥƤ꣩һΪĩÿǮˮһյ룬Ƭ߷֣ȥң·

ϢӣѣȥƤ꣩Ӷöȥȡף϶ζȽӵΪĩԼӰ׺Ϊ裬ͩӴһʱڣ˳ۣ£ġһʥ¼裩

ຮƢй㣬йֹⶹޢȣӣȥƤ꣩һǮΪĩ裬Ӵÿʮ裬¡Ŀ

ƢʪףһףʮöȥƤĿ飩СظУ͸ȥɸĩ޲ʷ۴Ӵÿʮ裬ܲ¡ϼҽ

׼ãȡС㲻ߣһȥƤ꣬ƬʮƬһǮĥˮͬ壬ʳǰСÿǮˮϼҽ

ηʪಫǽ۷ʹ죬֮ʹ磬С㲻粻ȥ£΢ߣʲݣˣӣȥƤƣö֦ȥƤζˮȡȥ·һ˺ۡʲݸ

ʹ㺮ǽʹӽߣӶöڣȥƤưƬ˲ζҩζˮȡȥң·һ˺ۡ

зƫϣһȥƤ꣩ǼҩһΪĩÿǮˮһյ߷֣ȥ·׷ۡǼɢ

η纮עƫͷʹòһƬԽ֭һյˣٽˣֹ֭ȷ֣ΪĩÿһǮ£ʱ򷽡Чɢ

ͷʹһöȫЫöȥ۶Ǯ롣øȥģȫЫڸڣȴȫΪĩͬˮ죬ΪϸĩΪ裬ͩӴÿʮ裬ʳǰͬ¡һɢв¡強Ы裩

ͷʹӣڣʯࣨѣȷ֡Ϊĩԡ°Ǯر

ξѪʹ顢ӣڣȷ֡ΪĩÿǮˮһյ˷֣ո·׷ۡС¾

Ѫػһϴϸȡ֭þȡ֭һڣȥƤ꣬Ƭӣػ֭ڣɸ࣬ȡӱɣɽҩΪĩԵػƸӺͳɼͩӴÿʮ裬ķϼҽػ裩

ϹתࣺһöǮߣڣȥƤ꣬ĩ֮ÿĩǮôʮðˮһյ룬Ƭͬ߷֣ȥΣķ·ɢ

21С㲻ͨ΢ܱ֮ͨЧߣһڣȥƤˮڽãкߣһɢÿǮˮһյ룬߾ռ÷ɢ

22˺öգ΢ϸ˯СɫƣȥڣʲݣˣӣڣȥƤһöˮȥĭټҩ֭η¡˷΢"ƸӸʲ"

23ȣãȶƣȥڣӣڣȥƤһöϸˮһȥĭټҩ֭η¡˷΢˷"丽ϸ"

24µȣﺮȣ棬΢񺮣࣬ʹŻʹôһȥƤгƬʲݣˣɽӲһ·ּ࣬ӴоŸʹҩŻʹӽ۹һֹ˲ζ˷""

25񺮣˺ѷ⣬񺮣󣩡ҩʲݣˣӣڣȥƤһöˮʽһϡִη¡˷"ҩʲݸ"

26ʢˮ棩ôһöմԣΪĩˮɢʹ˷"ɢ"

27з̵ʣ費ѹˣбͷӣȥƤ꣬ȡһһľǮ֡ҩϺÿȡǮʮƬˮ룬һ·˷""

28粡̱бɬIJôͷȥƤ꣩֬Ϊĩԡ¾¡һΡ塢裬̧Ʋʮ裬ͷ˷""

29纮ʪԣľʣ㲻죩һ룬ͷĩǮʵ½һסףո¡޲ĩɡ

30ͷȥƤǮ롢֬ΪĩѪͳӣӴÿһ裬¡

31С棩ͷȥƤ꣩һȫЫʮȥβÿˮһ롢Ƭҩ¡

32СضݡͷӣȥƤ꣩ۻư˷֣ΪĩԴи2ݴ

33ʹúڸһȥƤ꣩Ϊĩ֭ɸͿʹҩͿΪֹ

34ͷʹôͷǣȷΪĩ֭Ϳ̫Ѩ

35ֹͷңѣȷΪĩ޻ڡһ컻ҩΡ

36ʹøһջңݷһ֣ΪĩַͷӣϻӣСڡÿưһҧУַڸĩУʹֹ

37麮ʹ¹ףȥë΢ƣӣڣȥƤ꣩λ֣ҵĩ裬Ӵÿʮ裬ķ¾¡

38űøһöǮߣлУȻȥ棬˲ΡɰһǮΪĩӣӴÿʮ裬δǰҩЧŻľоٴηҩ

39ˮйôͷöһöãһöԺڶͬ죬һΪ裬̶ÿ裬¡

40Ѫػһ֭Ӿ츽һ룬ȥƤ꣬гƬػ֭ڣʯɸ࣬ȡƬɣͬɽҩΪĩԸĩΪӣӴÿʮ裬ķ¡

41ǡ츽ΪĩÿǮӽƬˮһɣ·

42¾츽ӣȥƤȷ֡ÿǮˮ

43Ӹ׶ôͷһĩҺͿͷҩˮʪ

44۴ʹô׺͸ĩͿҩͿ

45ѢôͷУˮϴ顣

46㶳ѡøȥƤΪĩˮͿЧ

Ԫأ"԰Ϊ˳ʪ֮ʥҩʪҩټ֮""֮ԭ裬нڣڡҲ"

ڡҺݡ"ӣ֮гζ̫ȣΪ֮жֹɽֹҲ߲֫ã֮Ҳ"

ࣺ"ߣøвΡΣ˶ʪټڡо""塷۸ȣͬΪһΪãӣȻδҲپζԸΪ򵼣䲹ǵػΪԸΪҩӡ֮߶أȡ佡֮ԣеػ֮ͣԶ"

ܡ˺Ҫ"ӣ֤Ҫҩ˺кȶ֮߱丹ʹϸߣ֤֮֮֮˺Ʋøӣֱ߶֮ѳӡҼ˺˥뼱˲νԭԸӣ¾ɢ˲ãԾ֮"

ң"׳֮ʣնضὫ֮ҩʮ׷ɢʧ֮ԪѪҩѪ֣֮ɢҩڱ֮纮ůҩ½֮ʪ"

ޡܡ"ۣϣϽ飻ӣ£½飻ͷضƣӺҲӣ䷢֫ƤëΪη֮Ҳ๣˹ͨ硢ؽڣѰᄊֱֲҲ"

ߡĿ"ϾԭƣͣƢ𺮣ͷ裬Ƣȥ磻Ǻøӣ缲ôͷһƣз磬÷ҩڡҩڡҲַڡҩߣҲ£ϸ֮Ժ֮ȣܸɡҩ֮Ա㷢Υ飬´棬˷֮ҲپκڽᣬۼͷЧκ˸Ӻ֭֮쵤ϪͷӣźҲ""ڡҩΣãҩټݡ˲ŷǮذﲻ˲ΪҩŽͬҮ?ݶ䣬ԸӼƣꡣޭŰٻƽ¹ףҩʮ࣬ˣอ֮ƫ֮޺ԳҲ֡¼Ի̨ࢸʹȻ"

ࡶ"ӣԻͬܳ溮䣬ǿů࣬ԣ㲻ͨ˾С֤ԴƷȣΡγɹؽЧ۱֤֤ϸá"

ᡶݻԡ"ӣɢ̵ͨؽ֮ҩҲ㣬ʺʳ룬ҩߣҩѨ֮ԭ֮Ϩӡ֮֤ߣ֮֮⹦"

⡶ݾ"ӣζ£ѸΪһƷҩƣ纮аǺа֮ϽҲʪbLϥʹ.вǺа½ҲYѪǺᣬѪҲ۱ݡан֣кů£ѪůҲ϶ķΣ¶жƢθԼѪӪʪߣвˡ㣬󺹡к󴭣з䵹̴֢˴֮ƷأˡҲ""ҩ󺹲ֹΪپȷӭ֮ΪپͨԾ̫֮֮ʶȣʹ֮ѣ֮ʹ¶϶ͨϿ֮֡ݶ飬Ͽ൭֮ߡֶ¹̡پø֮жߡ֡ʲУڵػơкУ綬տɰ鷨ҲԽ֮ȣ顢ۣ֮տηҲø֦֦֮ȥӰʲݸʪҲҩʲݸ²ˮҲ֭ͨͨȡ֮Ԫд֮ӡ"

ϡ塷"ӣ´ȣߣΪͨʮ֮ҪҩƤëԪ䣬ڳ⣬磬溮޲ΡңȺ£ûؼ죻⧱֢֮֫壬΢кγߣòΪ֢֮пɻͼߣýΪѱΩƸн֮ҩֽ֮ˮУȥζʵζһ̣֮ˮ֮þƣԼھʧƬߣԸɽǵΪ֣йãǮó֢֮࣬ʵ飬ƬǮв֦֮ӦԾ̭߹ӡԹ֢һǮЧ߱ǮǸ˴£ʵԵ֮棬зǴ˲֮ơͷڣӶ̫ңǸҲٱʤ֮ȯӡ"

ٴӦá˥:츽ƳעҺÿ2ˣע䣬ÿ2ÿ34ΡƸԭ˥13ԭݿ1ҩ˥ߵõƣʼѡ״󡢸׵̼ᡣӦúмȵĸãʧ

ժ¼ҩǵ䡷


лݡҩǵ䡷

ҩơ

ƴFù Z

ӢPrepared Common Monkshood Daughter Root, Prepared daughter root of Common Monkshood

ԡũݾ

1.񱾲ݡӡͷۡ๡ӣ֮ͬգ԰׻`֮ʹɡַ༰֮ǰ

2.ͼͷɽȣɽȣӡΪɽȼ㺺񲢳ȻƷһֳݡ֮ǰȽ½塢߱飬֮Ȼ֣ѣ

ԴҩĻԴΪëݢֲͷ

ֲﶯAconitum carmichaeli Debx.

պʹأ6ѮѮڳȫ꣬ȥɳժȡӸӣȥ฽ӣӹ

ԭ̬ͷݱ60-120cmͨ2ĴΣƤںɫƷIJӸʴֱ5cmֱб²⻬ëϲɢëҶʣбҶƬԲΣ5-12cm3ѼƬ2ѣƬ״ШΣȶ3dzѣƬԵдֳݻȱ̡״Բ׶򣬻ëƬ5ɫⱻ΢ëƬΣ15-18mmԼ20mmƬԲΣ2ë˿°벿ųɿεij᣻Ƥ3-5ܱһɫĶëuȋԲΣߺ޴棬â״6-7¡7-8¡

ֲ̬ɽز»ľС

Դֲֲϲࡢɽաա㽭ϡϡ㶫ĴݡϡҪĴϡϵȵҲࡣ

״1.״ 1θԲǯ׶Σ4-7cmֱ3-5cmҺɫ˪аݵѿۣΧ״ͻ֧֧ۡءҺɫɼ˪С϶εγɲ㻷ƣڲв롣΢ζ̶飬ࡣ

ԸʼʵҺɫ⻬Ϊѡ

2˳Ƭ ΪƬϿխ1.7-5cm0.9-3cm2-5mmƤںɫ氵ɫ߹󣬰͸״Ӳ࣬΢ζ

Ƭ󡢾ȡػɫйΪѡ

3׸Ƭ ΪƬƤưɫ͸Լ3mm

Ƭȡưɫ͸Ϊѡ

2.΢ ͷ棺ƤΪ1лɫľ˨ϸΪ8-9бϸڻɫľ˨ʯϸɢڣƤϸСƤռ󲿷֣ϸкɢСɸȺż1άγɲ㻷Գ߽Ρľʲܳλγɲڲ࣬Գ“V”λ״Уľ֯Ϸ貿ϸ

3.ĩһưɫٵ࣬λԲΣԲΣֱ2-20μmʵ״ʮ״״2-7ิ϶ɡںƤƬټ۳ʶΣܱڲеij״ͻϸǻǻںɫʯϸټɢڣֱԼ53-125μmƿԡܾԵƿ׼Ƶֱ20-48μmƸƬΪı֯Ƭ

ѧɷ֡Ӻͷaconitineͷmesaconitineͷhypaconitineͷtalatisamineڰhigeramineȥ׻ҩdemethylcoclaurineƼȻcoryneine chlorideݼisodelphinineͷbenzoyl mesaconitineneolinefuzilineͷbeiwutineͷkarakolineȥͷdeoxyaconitineͤfuzitine׼ͷsongorineणuracilͷjiangyouaconitine½ͷneojiangyouaconitineȥë˼salsolinolȡ

ҩá1.úͶڷڵӰ죺ڷ20%2.5ml100g50%2ml100gԼȩĴ׹ؽ׾зdzŵãP0.01츽Ƭ0.5gkgܷdzŵƴסӵļ״ȡƵСǻѪ͸ӺͽDz˽׹ؽסڷ300mgkg׹ؽڵԹؽ׵ñȿڷ50mgkg̫ǿڷ30mgkgʱѿ׵ñȿڷ20mgkgɵǿˮ崼Һÿ1ml=ҩ2gǻע䲻ͬڴ󣬶ԵԹؽ;вͬãǿҩԡԸӿõĻƿһбӺάC͵޴٣й17-̴ͪͬӣѪ԰Ѫ٣ø͸ӣ˷ܴ-Ƥϵͳáбгٺ󣬸ӵĿԱ棬Ϊ俹봹-Ƥϵͳ޹ءΪӱƤʼá

2.ʹ򾲺ͶµӰ죺0.1-1gkgڶѹȴβʹ͸ǻעСŤ巴Ӧˮ崼Һ1ml2gҩǻעС󣬿СʹֵСڷҺӳͱƵ˯ʱ䣬˶ܽ´2Сʱ֮ãƸͬáں£Һˮƺļʹ½ʹ͵»ָӳʱ䣬ʡˮ20gkgθС󣬿ɷdzӳܺСĴʣP0.01ˮŶԿСˮӦʹ񣻻ŶԿͺͷкҶСҩԸкȰ巨еʹõȣΪǸֹʹҩѧ

3.Ѫϵͳã

3.1.ǿĺѹãȥҩǸеǿijɷ֮һ΢Ѫϵͳúǿģλĺ˥ļȮעl-2μg/kgѹʺӣԺܶԼȫѪͣļӣļϸƵʺͷҲӡÿɱĵðϣЩصơеȥë˼һβ-˷ܼ˷ķƵʣעͻټѪѹӿʣټȥë˼ѹñУΪȥë˼жβ-弰α-˷áйƼԵѹǿãע40μg/kgʹѪѹ50%3×10(-6)gmlʹķȺƵʷֱ250120%ԻټèҲáѹÿα-ͼ-ȡѹüķҲܱ񾭽ҩ-Կ˷񾭽ڻǰάйء

3.2.ʺʧӰ죺ȥҩܼʣʵԻʧиáٴ۲Ҳ֤ʵȥҩԻʧԵáע󣬲˵ʾв̶ͬȵӣĶָˮƽ񼷿ͺͽҴܵõƣӶʹͼʧҪΪA-Hڡʵ黹ȥҩضβ-׺ƣڻСءӶֱ֤ȥҩβ-岿ּβ2-ҲԵļãñֱӼļB1-ǿΪ͸ӵĻṩ˲֤ݡ

ӵˮ֣ܲͷˮ֣ܲ60120mgkg൱СעLD50110-15ˮգעڴ󣬸ҩ5Ӻעͷ30μg/kg¼ʧʱȶӳ٣P0.001120mgkg6ֻ20ھδʧP0.001ڷˮܲ5501100mgkgԿͷµʧãõƵĽӵˮֶܲԾעͷ40μg/kg20μg/kgĴ󣬳ʧ5Ӻ󣬷ֱע200mg400mgkgʮָ500mg1000mgkgʮŵתΪɣP0.001ˮֶܲ۰򡢻ȷµʧЧͬһҩͬʱͶԿʧĻѧɷ֡

3.3.ݿ˵Ӱ죺ˮܲ2mgkg.min130mgkgעڶݿ˵èԶԿѹBPѹLVPѹʣLVdpdtmaxĽͺʺͼӳʱ䡣ڶݿáȡ801ӳݿ˴Ĵʱ䡣

3.4.ѪӰ죺ѪܵãӼȮèĺ֫ѪܣͷҲдáע丽ˮܲ7.51530mgkgʹȮɶѪֱ3070129%0.4250%ÿά10ңÿɽøӺ֫ůԭ

3.5.ļȱѪӰ죺עҺˮֶܲԼļȱѪԵıáӳСȱʱ䣬ͼøԡԿҶĴļȱѪżٽǰ֧ȮĤͼSTεԼSTߵ

3.6.ãˮӳѪøԭʱ估Ѫøԭʱ䡣ǿעҺÿ1mlȥҩ3mg4ml5%עҺ400mlУֱȮԲģά־Σͬʱķڵⶨ񼷿ָʱ䣨SNRTcĤ𲫵⡣ָעʼӿ죬SNRTc⣬𲫵ҲƶĴμ𲫵񼷿ΪٴƲṩݡˮдٽѪСۼáͷнѪá

4.߹ܵӰ죺۲츽עҺСѪܾøԡѪҺ弰Ƣ࿹ϸͶѪ岹庬Ӱ죬ֿСҺ߹ܼѪ岹庬СѪܾøӰ죻REϸתʵоԻϸӰʱ֣עҺʹTϸREγϸ0.4mlkg.d9죨Ƥע䣩ʹܰϸתձȽP0.01

5.鶯ģ͵ûƣøЧҺɫ-绯ѧãԻΪӶԼⶨɵԵ񾭵ʡ۲ҩӵЧɵȥأNA½أAߣP0.05)øӺָܻҿʹɵͰDAߣPֱ0.05P0.01)34-ǻᣨDOPAC½P0.001)ʹ5-ɫ5-HTߣP0.001)ҩ鼰󶼱ΪDADOPAC5-HT5-ᣨ5-HTAAֵߣP0.01-0.001)ʾԵøԡ

ԡӣδӹƷСڷLD50Ϊ5.49gkgעΪ0.49gkgӹСڷLD50Ϊ16lgkgעΪ2.8gkg츽ƬСڷ;עLD50ֱΪ17.42gkg3.516gkgˮ崼Һ1θǻעСLD50Ϊ26.30gkgȥҩСעLD50Ϊ58.9mgkgǻעΪ300mgkgڷΪ3.35gkg˫ͺ͵֬ĶԼ5ͷҪƺʧĶͨ˷Ͷֱ

ӣδӹƷСڷLD50Ϊ5.49gkgעΪ0.49gkgӹСڷLD50Ϊ16lgkgעΪ2.8gkg츽ƬСڷ;עLD50ֱΪ17.42gkg3.516gkgˮ崼Һ1θǻעСLD50Ϊ26.30gkgȥҩСעLD50Ϊ58.9mgkgǻעΪ300mgkgڷΪ3.35gkg˫ͺ͵֬ĶԼ5ͷҪƺʧĶͨ˷Ͷֱ

1ȡ˳Ƭ׸Ƭַ4g30ml백Һ5mlҡ20min˹Һ÷Һ©УҺ0.25mol/L20mlҡȡȡҺ÷ֹȷⶨ231nm274nmա

2ɫ ȡ˳Ƭ׸Ƭַ20g150mlҡ10minӰҺ10mlҡ30min1-2hȡѲ㣬ɣˮҴ2mlʹܽ⣬ΪƷҺȡͷƷˮҴƳÿ1ml2mgҺΪƷҺڼϵƷҺ6μlƷҺ5μl-11չȡɣԵ⻯ص⡢⻯ҺĵݻҺɫƷУƷɫӦλϳֵɫߣӦСڶƷɫ߻򲻳ɫߡͷ

ơ1.ƬȡθӣˮƯÿջˮ2-3ΣηƯùʲݡڶˮͬ͸пڳΪȣȡȥʲݡڶȥƤΪ꣬ùڼˮԼ2СʱȡɹΣ͸Ƭɹɡÿθ100øʲ5ڶ10

2.ڸƬȡθϴˮһҹȥƤ꣬ƬټˮڳΪȣȡý1-3죬Ȼ죬ٱ߳ɸɣ𼱳΢Ϊȣȡ

ζʣȣж

龭ģƢ

Ρ棻ɢʪѣ֫΢䣻ĸʹ麮кˮףУ纮ʪԣҴ

÷ڷ3-9gƷ18-30g衢ɢãĩ󣬻гɱƬڻѨλϣð֮ڷã˾ü壻öƷ

ע⡿ʢȼٺи

1.塷ͷ๡ۡӲӷȣһҲֹԴС̡֮麮øӣȡƽԲ󼰰ߣȫԡҼۣȡߣǶԣϾ£ȡɢҲͷ֮ˡĶ֮

2.Ԫأ԰Ϊ˳ʪ֮ʥҩʪҩټ֮֮ԭ裬нڣڡҲ

3.Һݡӣ֮гζȣΪ֮жֹɽֹҲ߲֫ã֮Ҳ

4.ࣺߣøвΡΣ˶ʪټڡо塷۸ȣͬΪһΪãӣȻδҲپζԸΪ򵼣䲹ǵػΪԸΪҩӡ֮߶أȡ佡֮ԣеػ֮ͣԶ

5.˺Ҫӣ֤Ҫҩ˺кȶ֮߱丹ʹϸߣ֤֮֮֮˺Ʋøӣֱ߶֮ѳӡҼ˺˥뼱˲νԭԸӣ¾ɢ˲ãԾ֮

6.ң׳֮ʣնضὫ֮ҩʮ׷ɢʧ֮ԪѪҩѪ֣֮ɢҩڱ֮纮ůҩ½֮ʪ

7.ܡۣϣϽ飻ӣ£½飻ͷضƣӺҲӣ䷢֫ƤëΪη?֮Ҳ๣ͨ硢ؽڣѰᄊֱֲҲ

8.ݸĿϾԭƣͣƢ𺮣ͷ裬Ƣȥ磻ǺøӣRôͷһƣз磬÷ҩڡҩڡҲַڡҩߣҲ£ϸ֮Ժ֮ȣܸɡҩ֮Ա㷢Υ飬´棬˷֮ҲپκڽᣬۼͷЧκ˸Ӻ֭֮쵤ϪͷӣҲڡҩΣãҩټݡ˲ŷǮذﲻ˲ΪҩŽͬҮݶ䣬ԸӼƣꡣޭŰٻƽ¹סҩʮ࣬ˣอ֮ƫ֮޺ԳҲ֡¼Ի̨ࢸʹȻ

9.ӣԻͬܳ溮䣬ǿů࣬ԣ㲻ͨ˾С֤ԴƷȣΡγɹؽЧ۱֤֤ϸá

10.ݻԡӣɢ̵ͨؽ֮ҩҲ㣬ʺʳ룬ҩߣҩѨ֮ԭ֮Ϩӡ֮򣬷֤ߣ֮֮⹦

11.ݾӣζ£ѸΪһƷҩƣ纮аǺа֮ϽҲʪbLϥʹвǺа½Ҳ֢ѪǺᣬѪҲ۱ݡан֣кů£ѪůҲ϶ķΣ¶жƢθԼѪӪʪߣвˡ㣬󺹡к󴭣з䵹̴֢˴֮ƷأˡҲҩ󺹲ֹΪپȷӭ֮ΪپͨԾ̫֮֮ʶȣʹ֮ѣ֮ʹ¶϶ͨϿ֮֡ݶ飬Ͽ൭֮ߡֶ¹̡پø֮жߡ֡ʲУڵػơкУ綬տɰ鷨ҲԽ֮ȣ顢ۣ֮տηҲø֦֦֮ȥӰʲݸʪҲҩʲݸ²ˮҲ֭ͨͨȡ֮Ԫд֮ӡ

12.塷ӣ´ȣߣΪͨʮ֮ҪҩƤëԪ䣬ڳ⣬磬溮޲ΡңȺ£ûؼ죬⧱֢֮֫壬΢кγߣòΪ֢֮пɻͼߣýΪѱΩƸн֮ҩֽ֮ˮУȥζʵζһ̣֮ˮ֮þƣԼھʧƬߣԸɽǵΪйãǮó֢֮࣬ʵ飬ƬǮв֦֮ӦԾ̭߹ӡԹ֢һǮЧ߱ǮǸ˴£ʵԵ֮棬зǴ˲֮ơͷڣӶ̫ңǸҲٱʤ֮ȯӡ

13.ũݾ纮аУ𴯣֢ۣѪʪϥʹв

14.ҽ¼纮ĸʹתףἡǣǿֶ̥Ϊҩ

15.ʰš׽СָɶУȥȥƤ壬Ϳ֮ڣ֭֮ԡ

16.ҽѧԴҪƣȥอ㣬Ƣθ

17.꽣อ棬ʪʹθ׶ξգɢա

18.ùţζΪǿʡ

19.ݸĿ˺ޣкз磬̵ʣbСʪԣͷ磬ͷʹкƢйűòŻܣθҭӸҲ©䴯ϴ飬

20.ݱҪ纮ʪ

21.ݴ¡ζҰףһг֤֮

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