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2017-09-02 16:04 Ķ:

йҩ䡷

ҩơ

ƴHuán Qín

ӢRADIX SCUTELLARIAE

ɽ˲衢

ԴƷΪοֲScutellaria baicalensis GeorgiĸڣȥɳɹײȥƤɹɡ

״ƷԲ׶ΣŤ825cmֱ13cmػɫɫϡ״ϸۣϲϴֲڣŤ򲻹ƣ²˳ƺϸ塣Ӳ࣬۶ϣɫмɫϸĿ״пգʰɫغɫ΢ζࡣ

𡿣1 ƷĩɫƤάɢڻΣ60 250μmֱ933μmں񣬿׹ϸʯϸԲΡ෽λ򳤷ΣڽϺľ˨ϸػɫΡƵֱܶ2472μm ľάϣֱԼ12μm ϡбƿס࣬Σֱ210μmԣ 23 ɡ

2 ȡƷĩ1gӼ״20ml20ӣ˹ҺɣӼ״1mlʹܽ⣬ΪƷҺȡ˶ҩ1gͬƳɶҩҺȡնƷӼ״Ƴÿ1ml1mgҺΪƷҺձɫ׷¼ B飬ȡҺ5μlֱͬһԺ4Ƶȼ׻άҺΪϼĹ轺GϣԴ-ͪ--ˮ5:3:1:1ΪչԤƽ30ӣչȡɣ1ȻҴҺƷɫУҩɫӦλϣͬɫİߵ㣻ƷɫӦλϣһͬİɫߵ㡣

ơƬȥʣ÷ˮ10ӣȡ͸бƬСʱȡбƬעɹƷΪԲλ򲻹αƬƤɫغɫɫɫ߷״[]12飬ӦͬĽ[ⶨ]µķⶨգC21H18O118.0

ƻˣȡƬվ˷¼ DɡƷΪԲλ򲻹αƬƤغɫɫʷ״ԴߣIJеijɫ[ⶨ]µķⶨղ8.0

ζ࣬

龭ΡƢ󳦡С

ΡʪкⶾֹѪ̥ʪ¡ŻʪƦк㣬ȿԣȷʣѪӸ״̥

÷39g

ءͨﴦ

ע1޶ʪ·ȣ뻬ʯޢʡߵӦãʪкʹֳ֡ʲͬãʪ̽µĻ㣬¡ӡҶͬáȲȣɽٵ飻ηȿԣ֪ĸɣƤͬãѪУءƤҶͬãȶ񣬿ҩͬḁ́זXӦá

ժ¼йҩ䡷

˵ͼƬ

ҩǵ䡷

ҩơ

ƴHuán Qín

ġʤˡӡͷ飨ձݡճ¼Ԫˡҩֲ־

ԴΪοֲijգ^ɣѡ34ֲꡣڳȥ硢ɹʱײȥ˨Ƥɹȫɡ

ԭ̬ˣIJݡƽ衣

ݱԳԲ׶״ƤɫΣ2560ף磬⻬򱻶ëҶ״Ρλ״Σ1.54.5ף312ףȶ˶ۻ򼱼⣬ԲΣȫԵ߽ë⻬򱻶ëٵ㣬⻬жëޱж̱״ŧƫһΣɫëȶ5ѣڴΣϴ´Ͳ״ϲ󣬻ϸɫ22.5ף汻ɫë42ǿ1ӷ4ѣС4ԲΣɫ78¡89¡

ֲڲԭʵɽ¡ֲ֡ӱϡɽĴϡɽࡢɹŵȵء

״ʵԲ׶ΣŤֱ727ףԼ12סɫɫϲƤϴֲڣŤƻ򲻹ƣ²Ƥϸ˳ƻϸƣ¾ϡ״֧ۡӲ࣬۶ϣɫмغɫԲġϸʰɫغɫƬ״ϰ"ݻ"""пնӲ״ߣϰ"˰"ʪˮΪɫ޳ζࡣֳʼʵɫơƤΪѡ̡ɡɫơɰ״ʴΡ

ӱɹšɽɽȵء⣬

ĴĻˣΪֲ˵ĸҩƣϸֱһԼ0.51ףз֦ΪԵĻɫϲ

ѧɷ֡˸߰Ԫ߰ء߰ͻأᡢβ-޴ȡҶк߰

ҩáٿ׿̬Ӧ

߰߰ԪԢܹ嶯лãƼЭͬ߰Ԫνǿ߰Ԫܼس֮Sehultz-DaleӦ󱻶ƤӦ֯ƤӦƣڿ̬Ӧ棬߰Ԫ߰ǿ˴ֿ̬Ӧ˺˷ʴϸøϵͳSH-ø˹ԽͷţӦƽҲֱӵɳá߰Ԫ߰ƹ֮׼֢߲ܽС󣺶ëϸѪܵͨ͸ԣֹܷѹСγѪ

ڿ΢

нϹĿףԹڶ˾׺˾ŧ˾˫ԼĤȾãͷĤ״ЧʹùصȿѲҩԵĽɫԻСԹڶͽ˸˾ã治һ£СʵԽ˲ЧЧԹڶвPRãƦȾʹ֮β˺ӳڡԶƤ²Чɱ塣

۽

걨棬ȵļþע6˽46нãԺôˮ澲ע˽֮430ڷסδ֤ʵнã羲ע΢ã뾲עˮһ5/಻ʹȴ̷ȵļȡǻע߰ڷ˼ĸȵļþܽȡоһ£ֲԴδҩѧ춨ƷֻңƼעӰѪѹܸŽá˻Ƿнʣдһоȡ޽á

ܽѹ

ˮȡ߰ȮèþעθѹáڷܽԸѪѹȮѪѹʹԸѪѹȮѪѹڷĽѹãϲΪѣӱ֮Ľϲ˵ĽѹԭһΪϵֱѪܣҲѪܸѹֲͬScutellaria galericulata޽ѹá

ڼʵУ߰Ԫǿش֮߰˴ȡP˼ãá

ݶѪ֬Ѫǵ

˼ƼˣΪ111Ѫܵ޴/ֵ֮֬Ӱ죬ܽ޴7ܺõĴֱֵг״ټõĴֱֵƼ֮ܽʹѪ

޺͵⾷

˼ҴȡҺȮõ֭й߰Ԫϻ߰ԣӰ죻߰ʹ䵨ܵļ16Сʱڵأ϶飩ߣ2448Сʱʹ֮͡λԵã׿ëܿij˶ǿж񾭺󲢲ӰãССνн⾷Ч۲ⶨֻĽ⾷ã߰Ԫ޽⾷Ч

߰СԷǿйأ˼С䣬ÿǿƤƹ£˷߼ʧߵĸѪѹߡ

˸ע䣬ʿжܡèǿֱԾε֢״ʹ߰ȩɽСʿжʣǰ10˾Լ2.5ӲⶨȻ̼жСĸԪȩ麬ϸߣ֮߰߰Ԫ͡

ԡ˶ԼͣùθȡҺע䣬ʻ˽4/θ8ܣδκζԷӦ罫˽2/ᄇעڽãȱ򾲣ԺɼעȿڷԴöࡣȡA⼰ע䣬ʹðϸʱŽ͡

ơˣȥʣȥоˮÿˮԽ̳͸Ƭɹɣעɹȷ죩ƻˣȡƬܻƾƣȣĻ΢ȡɡÿ100ûƾ1015ˣȡƬĻ΢Ϊȣȡ̿ȡƬ潹ɫԵɫΪȣԣˮȡɹɡ

ζ࣬

١"ζ࣬ƽ"

ڡ¼"󺮣޶"

ۡҩۡ"ζʡ"

龭ġΡ󳦾

١Ʒ㾫Ҫ"̫"

ڡĿ"̫"

ۡ׹ҩԽ⡷"Ρ󳦡סľ"

Ρкʵ𣬳ʪȣֹѪ̥׳ȷʣȿԣʪк㣬ܣ¡©Ŀʹ̥Ӹ۴

١"Ȼ㣬ݣйˮѪգΣ񴯣ʴ"

ڡ¼"̵ȣθȣСʹȣСŮѪգ¶ѪСʹ"

պ뾰"α࣬ʹ"

ܡҩۡ"ȶθܣȥؽڷƣȿʣȸЯLʹĸ͡"

ݡջӱݡ"ȼ۴ŧӸ"

ޡҡ"࣬ȥȣͨ"

꽣"ηȿڿࡣ"

ࡶϱݡ"кλк׻𣬣ΣܣŮӱȣ̥лȲ̥ȣʵʵȡ"

ᡶĿ"ηʪͷۣʹȣȣʧѪ"

⡶"Ͻ̵֮ԣֹʧѪȣʪȣͷʹߣʣƷӸӸ֮ȣΰ񡢳ۣʵ½֮ȣܳףɬʹ󳦱սᣬѪ©Ѫ"

ϡѧҩݡ"ϴڣзá"

÷ڷ13Ǯ衢ɢãˮϴĩ

ע⡿١ҩԡ"ɽǡΪ֮ʹʵηɰĵ޼«"

ڡݾ衷"Ƣ߼֮кйкʹٸʹѪ鸹ʹƢйккƢˮףѪݾգСˮܺаȣѪ̥¶á"

СȾ䣺ˣȥģ˲θһ֡ΪɢÿһذҶ£ʱʥ¼ɢ

кλ𣬽̵ƬӻˣΪĩ裬Ӵ󡣷ʮ衣Ϫķ裩

ףˡӸȷ֣ΪϸĩΪƬÿƬҩ0.3ˣÿΣÿƬɹšвҩҽƷѡࡷ

ϺȾף飬ıˮСʱ˲ټӶˮΣϲҺ20ҺҺУpHΪ3.5ÿ100ˣ68ɫСʱȥϲҺװ벼мˮˣɣ飬ƬÿηƬвҩҽƷѡࡷ

ͷʹ̫ͷʹƫƬˣƽ͸ɹΪĩÿһǮ衢¡زءСոࣩ

̫ϲߣҩʲݶˣʮö뢣ζˮһȡȥҡ·һҹһ˺ۡ

ܣѪϸУˮȡǧ

ѪѪ򷢻ֹ£һȥкڸϸΪɢÿǮˮһյ֡ʱ򣬺·ʥݷɢ

αѪˣΪϸĩÿһǮճӴƵ¡·

θʮѺȴУ಻ֹ֦߶״ףգ˸ɣֽˣߴΣΪϸĩ׺Ϊ裬ͩӴÿʮ裬¾£սþ鷽裩

ϰ̥ˡΪĩ裬Ϫķ

θ裬дZ’bJLһΪĩÿǮԣ£ն顣ɾƣ档ұ

üʹ̵ˣơΪĩǮϪķ

ξĴѪƳ˶ǮΪĩƷ֤淽

λ𵤣ƻĩˮ֮G鷽

βѪʣˮֹˣϱɣŶȥģϼϸСÿǮˮһյ룬˷֣ȥ·ʱ򡣣ϼҲط

١ҩԡ"ˣúӡֹʹζӡĵɡĵӣûΡС"

ڡͼ"پ˺ƦкķûˣȣСҲֹ̫֮и˻ﰲ̥ɢûˡ"

ۡҽѧԴ"ˣηʪȣĿ׳࣬Ѫʢ֮ҩйлаϣ֮ˮ㣬仯ԴؾƣоţкξȣһҲãҲϽƤȣҲȥȣҲ˲ҲҲ̵ҲϽȼƢʪҲ̥ҲơơƣҲƳУϲѪǴ˲ܳο棬ʳй֮νҲ"

Ԫأ"ŧѪճʹأȾòߣҩʲͬáȼȥ̵ûˣϽʪûˣкλҲʹߣÿຮҩˡ£Ҹҩ֮"

꽣"ˣζйλ⼡ȣ̫Ҳϸʵвߣ²"

ࣺ"˽̵併ҲȥϽʪȣԾϴáƬкλɣƤ֮ߣ˷ΣŶ֮ˡ˰̥ʥҩԻΪãDz֪̥ѪѪУ̥ϡжҩܽУܲƢҲ"

ߡĿ"ԻкλƢʪԫƬηλδ󳦻𣻵ϪԻж𣻶پ֤С̫ϲ֤ºʹк֮޼Ի˿ģйƦȣǻ䡣ǻζ࣬ģʤȣкĻƢ֮ʪȣһ̣һθΣԾȷҲ鲻ߣຮƢθĸҲ……ʿ孡ֱָƣȣˣ಻֪֮ȣ˿Է֮ɢ֮Ҳ֮ȣ˺ʤȣۻ֮Ҳ""˵þУ֭εȣò˺ȣҩɣƤкλ𣬵ð̥"

ࡶݾ衷"ˣ࣬ԳаζʪʤȣȡߣаʪҲ㡢ݡйʤ֮Ҳ䱾ӡຮܳʪȣСˮԴҲѪߣʵѪ֣Ѫң˾ղͨʪȽ⣬Ҳ񴯾ʴߣѪᣬΪӸҲߣѪҲѪȣҲ¼̵ߣУ̵ٸʹСʹθʪȥθҲ¶ѪҲߣаҲߣʪʤҲຮ֮ʤаԽ⣬Ƿ䱾Ҳ""Ϊຮ֮ҩڳаDz֮ƷУʪ̵ȻຮθƢƢ߼֮"

ᡶݻԡ"弡ȣѣȻ޻˲Ͻ֮ɽٿɽȻ˲ͷĿ……Է֮弡ȣ֮ⶾ֮ɢĿŮ̥֮˸ư֮׼Ҳ"

⡶ҩƷ塷"пˣϸˣһƷ˷áǿרкθϽ̵֮ԴĿʹʧѪ߷ƣҲרк½֮δսᣬСǣСͣѪȱУ̥©ѪЮȸʹԣҲ"

ϡԭ"ԲȥȲˣDzרȣΪ࣬Dzͨ⣻רȣУǻ˲ܿйһľаһʪڪɻۡຮϾα֮ҩΩ֮ȣùԺ?ʵ߼гѪУŷһζ裬ŮѪȣˮ²ֹߣЧ"

С֤"پûɣȽߣΪС֦ɽ֦ѪȽߣҩΪ֦׼衢V衢ɢɢʪߣΪкʲкк˻ɽ˻˲Բ֮ܿᣬй֮ȣҩܿѪ֮ᣬѪ֮ȣʪ֮ȣ֮ʪƩ֮⶷ȥ䶷ߣδƽ¶֮ŭδҲʻЭ֮ȣЭҩйѪ֮ȣЭ֮ܽʪҲ"

ٴӦáСԺȾ

50˼Һ1ÿ618105üӣԷ3ημϺȾ51֧11Ա1κ½֢״ʧ51Ч12¶3ڻָ֢״ʧΪ4졣

ȡ1ʲ0.5ˮ2ΣüҺ3ȡʯ1俪ˮ10ݾ24СʱȡҺ8ҺʯˮУ߼ӱ߽裬pH78Ϊֹÿ2025շ3Ρ35ٴ2Ч16ԵЧϺá

ƼԾ

ȡˡڭӵƳɷۡÿ2ˣշ4ΣСü֢ƣʧˮ߲ҺϽȼ100ƽ2.5֢״ʧ3.3㾵4.3ת5.3ٴ

ƹ岡

ȡˡ̵ֱƳɻؼ̽࣬ƳƬÿƬ0.5ˣ൱ҩ3.7ˡÿ1015Ƭ6Сʱ1ΣСü65һ5958һ6ʧ4ЧԭдоЧҩ󣬿ʼʱƽΪ7.5Сʱ»ָʱƽΪ1.8죬ٴ֢״25ڼʧԶСȲЧϺãȽϿ죬ضڲȽЧϲҩڼδضԷӦ΢ġŻ¼кͣҩ󼴿ʧ

ƴȾԸ

˵ȡ-װңÿ0.25ˡÿ2շ3ΣͯüƼԴȾԸ27Ծ֢״1ʧιָܻư£ȱתøռ74.1ûÿռע240ˣ1ΪһƳ̣Ƽ޻͸134Ч1Ч6̥֯Һÿ켡ע2иˮǨԸ74Ч1Ч2Ը4713Ч6Ч14Ч14δԸá

ס

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ƸѪѹ

Ƴ20ÿ510շ3Ρ51ҩǰѪѹ180/100׹ϣҩ112ºѪѹ½20/10׹ռ70ϡһٴ֢״Ҳ֮ʧᡣݹ۲죬ҩ侭ϳʱڷãܷӼѹáԸá

⣬Ի˼徣Ԥɺȣ˺ƬԤ׺һá

עֲͬͬҩã

ճëˣƻˡ̬ƣΨֲϰ߽1027סɫܱëëСëɰءĵػ¡ֲɹšɽӱȵء

ڵˣϻˡֲ갫С1025סֱÿڼܱаɫëëҶƬԲλΣ3.5ףԼ1.2ףȫԵԾݣ豻΢ëޱ״ɫܱëëСԲΣغɫëɽֱ߻ּ䡣ֲĴϵȵء

۸ˣ̬ҶϿ״ΣҶԵвȵľݣҶʯɽϡֲࡢɽ

ܱҶˣֲСԼ35סҶϱëɢëҶԵ߶ëɢٵ㡣ֲĵȵء

ˣ2036ףСëҶޱԲ״λԲΡڻưɫɫ̻ɫϰߡԡ»¡ֲ

޴ˣ1030סҶƬΪΡڰɫ̰ɫɫɫСΣڲ¡ɽɭԵֲĴ

ժ¼ҩǵ䡷


˵ͼƬ

лݡ

ҩơ

ƴHuán Qín

ӢBaical Skullcap Root

ġʸʤˡӡͷ顢ճˡˡˡԪˡɽƽ

ԡձݡˣҶֵգлԱijߣ»࣬ʵڣơ²ɡ

1.¼鴨ȼԩ䡣ղɸɡ

2. պ뾰ˣһǣ֮ԲΪʤˡ丹нáΩȡɫʵΪá

3.Ŀ˾ɸпգںڣνƬˡ¸ʵ

ԴҩĻԴΪοֲˡˡճë˺˵ĸ

ֲﶯ1.Scutellaria baicalensis Georgi2.Scutellaria amoena G.H.Wrignt3.Scutellaria uiscidula Bunge4.Scutellaria likiangensis Diels

պʹأ2-3ջҶݻʱѡȡŵľҶȥɹɣײȥƤɹɻɡ

ԭ̬ݱ30-80cmΣϸƣëչ΢ëɫ򳣴ɫԻ֦ϸҶޱޱҶƬ״Σ1.5-4.5cm3-12mmȶ˶ۣԲΣȫԵɫë΢ë浭ɫëܱɫݵٵ㡣״ƫһ࣬7-15cmƬҶ״Բ״Σ4-11cmëΣɫϴж״ʱʣڶΣɫϺɫϴ״ȶ΢ȱ´Ƭ״ԲΣ7.5mmƬϴϣڹϸ4¶ҩѿаɫëӷɫë4ѣڻ״ϣϸȶ΢ѡС4Σ1.5mm1mmںɫ6-9£8-10¡

ݱ20-35cmΣԾ߲ۣDZë֦򲻷֦ɫҶҶ̣1-2mmҶƬʣԲ״λԲΣۣ1.4-3.5cm7-14mmȶ˶ۣԲλШdzΣԵвԵԲȫԵ氵ɫëë浭ɫܱݵٵ㣬ëгɶ5-14cm״򣻰ƬҶ״״ԲΣ5-10mmΣɫƬĤʣʱ󣻻ڶΣɫɫ2.4-3cmⱻë4˿ƽӷëϸͷ΢ѡСΣغɫ5-9£7-10¡

ݱ20-35cmֱɫΣëвdz1.8-3.6cmҶҶƬԲ״ԲιԲΣ1.3-3cm6-15mmȶԲۣʱ΢ȱԵввԵԲݻȫԵɫϡë浭ɫܱٵ㡣ھл״򣬳6.5-12cmƬҶ״ëΣɫܱëƬԲΣʱۣڶΣưɫɫ̻ԣзϰ߻ƣ2.6-3cmܱëͲ״4ӷ4ѣϸͷ΢ѡС4ɫΣ5-8£7-9¡

ֲ̬ں60-2000mɽ¡ĵϣ·ߡ

ں1300-3000mIJݵػ¡

ں700-1400mɳIJݵء

ں2500-3100mĹԻϡ

Դֲֲڶɹšӱɽࡢɽϵȵء

ֲĴݡϵȵء

ֲڼ֡ɹšӱɽɽȵء

ֲĴϲ

ࡿѧ ϲůˬϺͺ񤱡ֲ²ֿ-30ĵ¡㡢񡢷ֵԻ΢ɰΪˡ

༼ ӷֳֳָӷֱֳԷֱʡȨ٣ߡ3-4Ѯﲥ8Ѯо30-45cmÿ1hm215kgҡ󣬷2-3μ磬12-15cmֳָȡδȷ3˸ȡҩãȻݸȻ״гɿ飬ÿѿ2-3֡

ڳӦʪʱݣÿ׷2-3Σ6-7Ϊʢڣ׷ʩʻ炙׸Ƶȡֵ⣬֮ǰӦȥ

溦 Ҷݲ԰11200Һ50%1000ҺΡעˮʵ溦л꣬90%аٳΡ

״״ 1 Բ׶ΣŤ5-25cmֱ1-3cmػɫɫֲڣԵƻ򲻹ƣ߲кۣоۻӲ࣬۶ϣɫмɫϸľ࣬غɫп߳“”΢ζࡣ

ʼʵɫΪѡ

2 б1cmϡԲ׶εIJ״з֦5-20cmֱ1-1.6cmƺɫػɫдֲڵ˨Ƥơ¶֧ۣά״ʻɫ΢ɫ

3ճë ϸԲ׶λԲΣ7-15cmֱ0.5-1.5cmƣпջࡣ

4 ԲΣз֦8-20cmֱ0.2-0.5.cmɫɫϸм԰ɫࡣ

΢ 棺1 ľ˨ȥдУϸʱƽ״żʯϸɢڡ˨ڲխƤϿ㣬Լռֱ1/3жƤάʯϸʯϸķֲ࣬ƤάֲڲࡣƤ߿Ϊ10-25ϸγɲɻľʲԼռֱ2/3ľʲ6-10ľ߿ƽֱ7-25бϸֱ16-60μmϸһͬеľ˨ƷϸԲΡԲκͲΣ4-32μm̾4-24μmƲ׼ʵ״“”ΣеIJԣΪ٣2-3ɡ

2 ľ˨Ϊ6-9ϸƤԼռ1/4άɢڣżСʯϸʯϸΣΡγɲ㲻ԡľʲ8-13ľ8-18бϸֱ28-44μmľ˨ֱ2-12μmδ޲ơ

3ճë ľ˨Ϊ5-8ϸƤԼռֱ1-3άɢڣżСʯϸγɲԡľʲ7-13ľ7-21бϸֱ40-80μmľ˨㻷ʯϸɢڡֱ2-12μm“һ”Ρ“”Σ޲ơ

4 ľ˨Ϊ6-9ϸƤԼռֱ1/3ʯϸάľʲ9-10ľ8-19бϸֱ20-40μmľ˨ݷԲΣֱ4-10μmδ޲ơ

ĩɫƤά΢ɫΣ˼Բ51-200-270μmֱ9-33μmľ׹ԡʯϸ෽ΡԲΡԲΡΡΡƴλ򲻹Σֱ24-48μm85-160μں24μżɫʯϸԲΣֱԼ66μm۷ĴľϸڵԣԺ񣬷ľϸвзƱ ƤϸĴλԲΣʱ״񡣢ơԵƿ׵ֱԼ72μܷӽ϶̣˱бӳβ״ʱŤ״ľάϸԺ񣬾бƿ׻Եƿסеľ˨ϸ

ѧɷ֡1. ͪ໯أbaicalein)أneobaicalein)˻ͪskullcapflavone򣩣߰baicalin)أwogonin)߰wogono-side)[1]ľAoroxylin,oroxylin A)[23]7-أ7-methoxbaic alein)[2]˻ͪskullcapflavone)[34]ľAdihydrooroxylin A)أchrysin)258-ǻ-7-ͪ2,5,8-trihydroxy-7-methoxy-flavone)258-ǻ-67-ͪ2,5,8-trihydroxy-6,7-dimethoxyflavone)457-ǻ-6-ͪ457-trhydroxy-6-methoxyflavanone)[5]23567-ǻͪ23567-pentahydroxyflavanone)-5-β-D-߰wogonin-5-β-D-glucoside)2-3-ǻ-4--һ-1-O-α-L-ǻ1→3-β-D4-κ-[2-3-hydroxy-4-methoxyphenyl)ethyl-1-O-α-L-rhamnosyl(1→3-β-D-4-feruloyl)glucoside][6]أ-6-C-α-L-߰chrysin-6-C-β-D-glucoside-8-C-β-L-arabinoside)-6-C-α-L-߰-8-C-β-D-߰chrysin-6-C-α-L-arabi-noside-8-C-β-D-glucoside)[7]2S-2567-ǻͪ[2S-2567-terahydroxyflavanone][89]5726-ǻͪ5727-tetrahydroxyflavone)58-ǻ-67-ͪ58-dihydroxy-6,7-drimethoxyflavone)574-ǻ-8-ͪ574-trihydroxy-8-methoxyflavone)ľA-7-O-ȩ߰oroxylinA-7-O-glucuronide)[10]572-ǻͪ572-trihyroxy-6-methoxyflavone)52-ǻ-678-ͪ52-dihydroxy-6,7,8-trimethoxyfla-vone)5-Ȼ-78-ͪ5-hydroxy-7,8-dimethoxy-flavone)ȥ׺أnorwogonin)أdihydro-baicalin)[11]572-ǻͪ5,7,2-trihydroxyflavone)572-ǻ-86-ͪ572-trihydroxy-8,6-dimethoxyflavone)5725-ǻ-86-ͪճëآ5725-tetrahydroxy-8,6-dimethoxyflavonevis-ciduiin 525-ǻͪ525-trihy-droxy-6,7,8-trimethoxyflavone)-7-O-β-D-߰(baicalein-7-O-β-D-glucopyranoside)[12]572-ǻ-8-ͪ572-trhiyroxy-8-methoxyflavone)ͻآtenax-in 򣩣526-ǻ-78-ͪ5,2,6-ǻ-6-ͪ5,7,2-trihydroxy-6-methoxyflavone)5723-ǻͪ572-trihydroxy-6-methoxyflavone)5723-Ȼͪ5723-tetrahydroxyflavone)357256-ǻͪ(3,5,7,2,6-pentahydroxyflavone)ճëآviscidulin 񣩣2S-726-ǻ-5-ͪ[2S-726-trihydroxy-5-methoxyflavanone]2624-ǻ-6-ͪ2624-tetrahydroxy-6-methoxychalcone)[13]5725-ǻͪ5725-tetrahydroxyflavone)ʥأeriodictyol)֦أrivularin)ճëآ-2-O-β-D-߰viscidulin -2-O-β-D-glucoplyranoside)[14]ȡ⻹β-޴β-sitosterol)޴campesterol)޴stigmasterol)[3]2. أأ߰߰572-ǻ-6-ͪ[1516]2S-578-ǻͪ[2S-578-trihydroxyflavanone],(2S)-2,5,6,7-ǻأľA߰scuteamoenoside)2R3R-2357-ǻͪ[2R3R-2357-tetrahydrox-yflavanone][17]أscuteamoenin),(2R,3R)-3,5,7-ǻͪ-2R3R-357-trihydroxyflavanone]˻ͪ23567-ǻͪأβ-޴[16]3.ճë ߰߰[1819]أأľAأ52-ǻͪpanicolin)˻ͪճëآ񡢢[19][1920]

4. أأأľAͻآճǧܻآ[21]

ֲͬ˸أrehderianin)ճëآ[22]߰أأľA߰Ԫganhuangenin)[23]˸߰߰أճëآ񡢢ľAͺ[24]

ҩá1.ã˼100%Ũȣƽ巨飬˾˺˾˺˾һ󳦸˾θ˾ŧ˾ѪaB˫׺˾á˼Թܷ11280 Ũȿ˺˾Ѫ a1640 ŨѪB˫˾˽˸˾ H371320 Ũȿƻһ־˾180 Ũʱ˾á˴Һ0.5g/ml0.05g/ml֬бҩҺ11 ϣŧ˾á˴Һ2g/mlŨȣƽԴ󳦸˾۲ݸ˾ɫá˼ 1g/mlŨȣƽ巨ʱĤá

2.ã˼ҺԹб淨4%ŨƹСɫëѢ8%ŨϻѢ10%ŨϻѢɹű֣15%ŨƹëѢɫëѢˮ13ŨԹڶɫëѢͬëѢϻѢ¶ŰСѿѢëСѿѢɫƤѢKWϱƤѢūϾв̶ͬ־á

3.ã˼25-100%Ũȣ͸ײDNAá

4.׿̬Ӧ70%Ҵȡ200500mg/kg θء߰50100mg/kg θƴСǻӣ48/80һֻƣSigma ĴҲã70%Ҵȡ500mg/kg θء߰100mg/kgθ ԴԹؽáˮ100200mg/kg θԴ󱻶ƤӦPCAãȻСӴƤףͣӰ졣ƱƤӦPCAЧɷΪ߰ء߰ضʵЧ߰10-4g/mlŨȿSchultz-DaleӦ38%п鰷ڼáزˮˮ-6-ƣBPS-6-ƣBSSڿԭǰ5mg/kg ע䣬ԴPCAã10mg/kg ע ڿԭǰ10ӸҩãBPSBSS10-4g/mlŨȶ󳦹ܼchultz-DaleӦãBPSBSS 5mg/kg ע䣬ԴƤӦRCAã5-10mg/kg עҲForssmanƤѪףArthusӦӰ졣ؼBPSṹ뿹ҩɫƣDSCGƣDSCGΪ˫ɫͪ࣬ؼBPSΪɫͪ࣬DSCGԷӦأReagin鵼ĹӦи߶ԣԷǷӦأIgG鵼ĹӦãPBS򲻽ƷӦؿ鵼ĹӦPBS 10-6-10-4g/mlƿԭĺνͷţPBS 200mg/kgǻעƴͬPCA10-4g/mlƷӦؿ鵼ĴʴϸѿȣҲƷǷӦؿ鵼ķӦBPS10-4g/mlѰ׵ͷŽʼƿIgE˷ͷŹʣΪDSCGɫͪ˼һ룬ɽڷӦؿ幦λϣʺڷǷӦؿ壬ɫͪĻػBPSӽֿϡضԴѪС廨ϩллø֬øã֬øѡԣIC50Ϊ0.12μmԻIC50Ϊ6917֬øضԴϸƻϩл֬øл5-ǻʮ̼ϩᣨ5-HETEøл12-ǻʮ̼ϩᣨHHTɣIC50ֱΪ7.13±0.767μm5.53±16.9μm߰԰ϸ5-HETEγҲƣHHTγɣHHTγɣIC50Ϊ14.6±3.51μm˳ɷֶԻ48/80̼ǻʴϸͷ鰷ãصIC50Ϊ52.1μm߰IC50Ϊ200μmصIC50Ϊ40.0μm-7-O-DȩIC50Ϊ140.0mol/l252'56'7-ǻͪIC50Ϊ17.7μm2R3R-2'356'7-ǻͪIC50Ϊ15.5μm(Chrysin)IC50200μmآSkullcapflavon 򣩵IC50Ϊ15.0μm߰10100mg/mlԸA23187յĴǻϸPGE2TXA2á

5.ϵͳã˼4g/kg ǻע䣬СʹԷʱӳԷ估ֻӰ죬˵˿ɼǿƤƹ̡˼2g/kg˺ȼнáҲбˮƽ5-9g/ֻθ2g/ֻim֤˶˺ȼнá

6.Ѫܵã˴Һ1g/kg ע䣬ʹȮѪѹ½˼0.06g/kg ע䣬ȮԽѹá20mg/kg ע䣬ʹȮѪѹ½40-50%˽θ/kg θ3/죬4ܣʹԸѪѹȮѪѹ½ʱ߰2×10(-4)mol/lζķоԵ׿أȥؼͰãҲ׿ܺķԷƵãʾ߰aB1B2 á

7.ѪСۼءءǧֽA˻ͪ򼰰أchrysinŨ1.0mMʱƽԭյĴѪСۼضADPյѪСۼҲãؼضԻϩյѪСۼҲãؼ߰ѪøյάԭתΪάҲƣؼ߰2050mg/kg θڶյĴѪѪԷֹѪС弰άԭĽ͡

8.Ѫ֬ãˮҺ10%2ml/ֻθҩ7ܣʹ̴ιǵļѪ嵨̴½ء߰100mg/kg θɽʵԸѪ֬-̴-ιѪ֬ᡢθĺ˻ͪ100mg/kg θɽѪ̴ܵθĺѪܶ֬-̴HDL-chĺ 100mg/kg θɷֹθijѪHDL-chĺء߰ 100mg/kg θҴĸѪ֬󣬿ɽ͸̴ܵ뵨̴ܽѪˮƽѪHDL-ch

9.Ρ˼״ȡ1000mg/kg ǻע䣬ANITĴãѪ嵨صӡ˴50100mg/kg߰50100mg/kg θԼá10(-4)-10(-6)mol/l Ũ飬Դ΢֬ʹãʹȩMDA½ؼ߰2.5×10(-4)mol/l1.0×10(-4)mol/l2.5×10(-4)mol/l˻ͪ2.5×10(-4)mol/l-7-O-Dȩ2.5×10(-4)mol/l1.0× 10(-4)mol/lFeC12-άC-ADPյĴȽ֬ʹãʹMDAγ½NADPHһADP֬ʹҲơ

10.ãСѪL1210ϸϸãЧΪ10.4mg/ml˻ͪСL1210 ϸİЧ Ϊ1.5μg/ml߰ؼضL1210òš

11.ã1020mg/kg ע䣬Ȯá˼4g/kg θԴ԰зãӻϵγɡ߰ԴȩǻԭøãID50 Ϊ1.81 × 10(-3)mg/ml߰150mg/kg θù򲡴Ѫˮƽ½ϸɽ洼ƺŽͣʾڶҲȩøãпԲ֢ķΡ߰ؼ50-125μg/ml СҺøá߰100mg/kgȩ43mg/kg ƤעɶԿʿС߰ԪЧΪ߰ˮȩĽⶾá˶PGsĴлнϹ㷺Ӱ죬ˮPGsϳá

ԡ˶ԼͣùθȡҺע䣬ʻ˽4 g/kgθ8ܣδκζԷӦ罫ƽ2g/kgעڽãȱ򾲣ԺɼעȿڷԴöࡣȡA⼰ע䣬ʹðϸʱŽ͡ظǻעСİΪ3081mg/kg˽15g/kg/θȮŻ5g/kgθ8ܣʹȮϡ

1ȡĩ2g100ml׶ƿУҴ20mlˮԡϻ15min˹ȡҺ1mlӴǦҺ2-3ΣٻɫȡҺ1mlþ3-4ΣԺɫͪ2ɫ ȡĩ1g40mlȡлȡҺɫŨɣ70%Ҵ5mlܽ⣬ҺȡغͺغͺΪƷֱͬһ0.25mol/L轺Gϣȷ-״101չΣƣ365nm¹۲죬ءؾΪɫȡIJ̶Ӿѣ50%Ҵݹҹ2hҴȡҺҺԻ߰Ʒֱͬһϣȷ-״-ͪ-ͪ161051չƣ365nm¹۲죬߰Ϊߡ

ơˣȥʣȥоˮÿˮԽ̳͸Ƭɹɣעɹȷ죩ƻˣȡƽƬܻƾƣȣĻ΢ȡɡÿ100ûƾ10-15ˣȡƬĻ΢Ϊȣȡ̿ȡƬ潹ɫԵɫΪȣԣˮȡɹɡ

ζζࣻԺ

龭ΣģΣ󳦾

ΡкʪⶾֹѪ̥ȿԣȲ裻λͷʹĿʹʪȻ㣻кܣѪ©̥ȲӸ۴

÷ڷ3-9g衢ɢãˮϴĩ

ע⡿ݾ衷Ƣ߼֮кйкʹٸʹѪ鸹ʹƢйккƢˮףѪݾգСˮܺаȣѪ̥¶á

СȾ䣺(ȥ)˲θһ֡ΪɢÿһذҶ£ʱ(ʥ¼ɢ)кλ𣬽̵ƬӻˣΪĩ裬Ӵ󡣷ʮ衣(Ϫķ)ףˡͤӸȷ֣ΪϸĩΪƬÿƬҩ08ˣÿΣÿƬ(ɹšвҩҽƷѡࡷ)ϺȾף飬ıˮСʱټӶˮΣϲҺ20ҺҺУpHΪ35(ÿ100ˣ68)ɫСʱȥϲҺװ˲мˮˣɣ飬ƬηƬ(вҩҽƷѡࡷ)ͷʹ̫ͷʹƫƬçƽ͸ɹǧΪδÿһǮ衢¡(زءСո)̫ϲߣƽҩʲݶ()ʮö()ζˮһȡ)ȥҡ·һҹһ(˺ۡ)ܣѪϸУˮȡ(ǧ)ѪѪ򷢻ֹ£һ(ȥкڸ)ϸΪɢÿǮˮһյ֡ʱ򣬺·(ʥݷɢαѪƽ棬ΪϸδÿһǮճӴƵ¡(·)θʮѺȴ ಻ֹ֦߶(״ףգ˸ɣֽˡߴ)Ϊϸδ׺Ϊ裬ͩӴÿʮ裬¾£ս(þ鷽)11.̥ˡΪδ裬(ϪΡ)12.θ裬дСһΪδÿǮιԣ£նɾơ档(ұ)13.üʹ̵(ƽ)ơΪδǮ(Ϫķ)14.ξĴѪƳ˶ǮΪδƷ(֤淽)15.λ𵤣ƻĩˮ֮(÷ʦ鷽)16.βѪʣˮֹ(ϱ)Ŷ(ȥ)ϼϸСÿǮˮһյ룬˷֣ȥ·ʱ(ϼҲط)

1.ҩԡˣúӡֹʹζӡĵɡĵӣûΡС

2.ͼپ˺ƦкķûˣȣСҲֹ̫֮и˻ﰲ̥ɢûˡ

3.ҽѧԴˣǢʪȣĿ׳࣬Ѫ¢ʢ֮ҩйлаڸϣ֮㣬仯ԴؾƣоţкξȣһһҲãҲϽƤȣҲȥȣҲ˲ҲҲ̵ҲϽȼƢʪҲ̥ҲơơƣҲƳУϲѪǴ˲ܳο棬ʳй֮νҲ

4. ԪأŧѪճʹأȾòߣҩʲͬáȼȥ̵ûˣϽʪûƷңкλҲʹߣÿຮҩˡ£Ҹҩ֮

5. 䣬ζйλ⼡ȣ̫ҲϸʵвߣǢ²

6. ࣺ˽̵併ҲȥϽʪȣԾϴáƬкλɣƤ֮ߣ˷ΣŶһ֮ˡ˰̥ʥҩԻΪãDz֪̥ѪѪУ̥ϡжҩܽУܲƢҲ

7.ĿԻкλǢƢʪԫƬηλδ󳦻𣻵ϪԻж𣻶پ֤С̫ϲ֤ºʹк֮޼Ի˿ңйƦȣǻ̫ӡǻƻζ࣬ңʤȣкĻƢ֮ʪȣһ̣һθΣԾȷҲ鲻ߣຮƢθĸҲʿ孡ֱָƣȣˣ಻֪֮ȣԷ֮ɢ֮Ҳ֮ȣ˺ʤȣ֮Ҳ˵þУ֭εȣò˺ȣҩɣƤкλ𣬵ð̥

8.ݾ衷ˣ࣬ԳаζʪʤȣȡߣаҲ㡢Ƨйʪʤ֮Ҳ䱾ӡຮܳʪȣСˮԴҲѪߣʵѪ֣Ѫң˾ղͨʪȽ⣬Ҳ񴯾ʴߣѪᣬΪӸҲߣѪҲѪȣҲ¼̵ߣУ̵ٸʹСʹθʪȥθҲ¶Ѫ,ҲߣаҲߣʪʤҲຮ֮ʤаԽ⣬Ƿ䱾ҲΪຮ֮ҩڳаDz֮ƷУʪ̵ȻຮθƢƢ߼֮

9.ݻԡ弡ȣѣȻ޻˲Ͻ֮ɽΦɽȻ˲ͷĿԷ֮弡ȣ֮ⶾ֮ɢĿŮ̥֮˸ư֮׼Ҳ

10.ҩƷ塷пˣϸˣһƷ˷áǿרкθϽ̵֮ԴĿʹʧѪ߷ƣҲרк½֮δʹսᣬСǣСͣѪȱУ̥©ѪЮȸʹԣҲ

11.ԭԲȥȲˣDzרȣΪ࣬Dzͨ⣻רȣУǻ˲ܿйţһľаһʪţڪɻۡຮϾα֮ҩΩ֮ȣ¶Ժʵ߼гѪУŷһζ裬ŮѪȣˮ²ֹߣЧ

12.֤پûɣȽߣΪС֦ɽ֦ѪȽߣҩΪ֦׼衢Ƴ衢ɢɢʪߣΪкʲкк˻ڽ˻˲Բ֮ܿᣬй֮ȣҩܿѪ֮ᣬѪ֮ȣʪ֮ȣ֮ʪƩ֮⶷ȥ䶷ߣδƽ¶֮ŭδҲʻЭ֮ȣЭҩйѪ֮ȣЭ֮ܽʪҲ

13.Ȼ㣬ƧйˮѪգΣ񴯣ʴ

14.¼̵ȣθȣСʹȣСŮѪգ¶ѪСʹ

15.ϱݡкλк׻𣬣ΣܣŮӱȣ̥лȲ̥ȣʵʵȡ

16.ĿηʪͷۣʹȣʧѪ

17.Ͻ̵֮ԣֹʧѪȣʪȣͷʹߣʣƷӸӸȷ֮ȣΰ񡢳ۣʵ½֮ȣܳףɬʹ󳦱սᣬѪ©Ѫ

18. ѧҩݡϴڣзá

ٴӦá1. СԺȾ 50%˼Һ1ÿ6ml18-10ml5üӣԷ3ημϺȾ51֧11Ա1κ½֢״ʧ51Ч12¶3ڻָ֢״ʧΪ4 졣

2. ף ȡ1ʲ0.5ˮ֮ΣüҺ3ȡʯ1俪ˮ10ݾ24СʱȡҺ8ҺʯˮУ߼ӱ߽裬pH7-8Ϊֹÿ20-25mlշ3Ρ35ٴ֮Ч16ԵЧϺá

3. ƼԾ ȡˡڭӵƳɷۡÿ3gշΣСü֢ƣʧˮ߲ҺϽȼ100ƽ2.5֢״ʧ3.3㾵3ת5ٴ

4. ƹ岡 ȡˡ̵ֱƳɻؼ̽࣬ƳƬÿƬ0.5g൱ҩ3.7gÿ10-15Ƭ6Сʱ1ΣСüǢ65һ5958һ6ʧ4ЧԭдоЧҩ󣬿ʼʱƽΪ1.5Сʱ»ָʱƽΪ1.8죬ٴ֢״2-5ڼʧԶСȲЧϺãȽϿ죻ضڲȽЧϲҩڼδضԷӦ΢ġŻ¼кͣҩ󼴿ʧ

5. ƴȾԸףƽȡ--װңÿ0.25gÿ2շ3ΣͯüƼԴȾԸ27Ծ֢״1ʧιָܻư£ȱתøռ74.1%ûÿռע֮40mg1ΪһƳ̣Ƽ޻͸134Ч1Ч6̥֯Һÿ켡ע֮иˮǨԸ7Ч1Ч2Ը4713Ч6ЧnЧ14δԸá

6.סף ûȡƳ5%עҺÿμע100-200mgͯ룩ÿ2Ρұ20ڼԴϢʳ⣬δҩ11ٴ֢״ȫʧҺϾ8תٴ֢״ȫʧҺ졢ϸ59ת׼ͬϣ41ҩ10ޱ仯Ƴ17.5죬7죬ƽ12.5졣ٴ֢״ʧʱƽΪ9죬ָʱƽΪ15.6졣ЧпѪѹˮйء

7.ƸѪѹ Ƴ20%ÿ5-10mlշ3Ρ51ҩǰѪѹ180/ 100mmϣҩ1-12ºѪѹ½20/10mmռ70%ϡһٴ֢״Ҳ֮ʧᡣݹ۲죬ҩ侭ϳʱڷãܷӼѹáԸãܴ⣬Ի˼Ԥɺȣ˺ƬԤ׺һá

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