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2017-05-06 15:22 : Ķ:

йҩ䡷

ҩơ

ƴK Shn

ӢRADIX SOPHORAE FLAVESCENTIS

Ұú֦ǡعǡػɽ

ԴƷΪֲSophora flavescens Ait.ĸڣȥͷС֧ϴƬ

״ƷʳԲΣ²з֦1030cmֱ12cmɫػɫƼ᳤ƤףƤѷװ䣬䴦Իɫ⻬Ӳ۶ϣάԣƬ36mmưɫ߷״϶еĿɼͬԻơ΢ζࡣ

𡿣1ȡƷƬҺΣ˨ƤʳȺɫΪѪɫòʧľʲɫӦ

2ȡƷַ1gӺ 05ҴҺ20mlȻ1Сʱ˹ҺӰҺʹԣɣ 1Һ10mlʹܽ⣬˹ȡҺ֧ԹУһмӵ⻯Һɺɫһмӵ⻯Һɻưɫһмӵ⻯صҺغɫ

3ȡƷĩ05gӼ״10mlȻ10ӣ˹ȡҺ1mlԹУþ34ΣȣԺɫȡҺֽϣ5ȻҴҺɣƣ254nm¹۲죬Իɫӫ⡣

4ȡƷĩ05gȷ25mlŨҺ03mlùҹ˹Һɣȷ05ml ʹܽ⣬ΪƷҺȡμͻƷҴƳÿ1ml02mgĻҺΪƷҺձɫ׷¼ B飬ȡҺ4μlֱͬһ 2ҺƱĹ轺DZϣԱͪ״8:3:05ΪչչչԼ8cm ȡɣԼױ״ˮ2:4:2:110·úϲҺΪչչչͬϣȡɣԵ⻯ҺҴҺƷɫУƷ

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ơȥͷСֿϴԼ͸ʱ͸кƬ

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Ρʪɱ棬Ѫգ״£ʪʪƤѢ磻εγס

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ժ¼йҩ䡷

εֲͼƬ /tp/14110.html

ҩǵ䡷

ҩơ

ƴK Shn

ǣĿΣ䷽ҩצҽҩֲţΣҩ־

ԴΪֲգΪѡڳȥͷϴɳɹɡʸƬɹɣƿƬ

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ժ¼ҩǵ䡷


ҩĿεͼƬ www.zyydq.cn/tp/14110.html


лݡ

ҩơ

ƴK Shn

ӢLightyellow Sophora Root, Root of Lightyellow Sophorn

ǡΡצţΡعǡҰɽزΡ

ԡũݾ

ԴҩĻԴΪֲεĸ

ֲﶯSophora flavescens Ait.[S.angustifolia Sieb.et Zucc.]

պʹأֵ39-10ȡȫ꣬ȥϲּ«ͷõɵϴȥɹɻɡ

ԭ̬ Ҷľ1.5-3mԲ״Ƥưɫֱ֦ݹ֦ëë״Ҷ20-25cmСҶ15-29ҶƬ״Σ3-4cm1.2-2cmȶ˽⣬Բж̱ȫԵƽëҶΡ״15-20cmëƬΣ״ƽ6-7mm5dzѣڵΣưɫΣ޶ǰȳ10˿룻ӷϸëͷԲΡԹΣȶ˾߳๣ʱѣ5-8cmӼ΢ʲԵĴ״ë3-7ţΣɫ5-7£7-9¡

ֲ̬ɳػɽ²ݴмϪߡ

Դֲֲȫء

ࡿѧ ҪϣһɰճϾΪֲӦѡˮλͣˮõؿֲ겥ֵ಻Ҷӱߣ괺·6ٿ7-8Ѯʵ죬ȫԼ210dӸ49.63g

༼ ӷֳǰ40-45ˮ10-12hɳأ13Ϸ0-10´20-30dϷ3-4£4²֣о65cm30cmѨÿѨ8-102-3cm1hm222.5-37.5kg¶15-19棬㹻ʪԼ25d硣15-16cmʱ硢磬ÿѨ3-4ꡣ

ʱݡˮÿ׷l-2Σ15СѮ28¼䣬Էʺ;ǷΪ

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ĩɫάڶľƽֱֱ11-27μmάΧϸкƷγɾάڵΪԵƿ׵ܣɫɫֱ27-126μmԵƿԲΣнܣеƿ׿״ľ˨ϸ۶ΣصƽܱڱвϸơܱϸԲλ೤ΣеĴܱڳʲ״ǻںϸС뾧11μm⣬ڶʯϸ

ѧɷ֡кμmatrineμoxymatrineN-N-oxysophocarpinesophoridineμ-allomatrineμI-somatrinesophoranolN-sophoranol N-oxidesophocarpinesophoramine-N-׻ȸN-methylcytisineanagyrine͵Ҷbaptifolineлֻͪ໯´kushenolABCDEFGHIJKLMNOβͪkuraridinβͪkuraridinolδkurarinol¿δneokurarinolδnorkurarinolͪisokurarinoneâأfor-mononetinͪkurarinoneͪnorkurarinone׻´Cmethylkushenol Cl-ɽأlmaackiainҶ̴߰trifolirhizinҶ̴߰rtifolirhizin-6”-O-malonateأkusheninˮ޽أisoanhy-droicaritinˮ޽أnoranhydroicaritinƸxan-thohumolƸᣨisoxanthohumolľϬ-7-߰luteolin-7-glucoside⣬л߰߰sophoraflavoside񣬢򡢢󡢢߰soyasaponinIԼ໯kushequinoneAϲֺμμһμμN-͵Ҷ-N-׻ȸ---N--7-⻱7-dehydrosophoramine컱isosophocarpine-1314ȥ⻱1314-dehy-drosophoridine-9a-ǻμ9a-hydroxymatrine-9a-ǻ9a-hydroxysophocarpine-9a-ǻ-N-9a-hydroxysophocarpine N-oxide-78-⻱78-dehydrosophoramine-9a-ǻ9a-hydrox-ysophoramineN-׻ȸ壨dimer of N-methyleyti-sine-12-ȥμlehmannine2-ɫͪ2-alkylchromone derivatives2-ʮһ-57-ǻ-68-׻ɫͪ2-n-heneicosyl-57-dihydroxy-68-dimethyl chromone2-ʮ-57-ǻ-68-׻ɫͪ2-n-tricosyl-57-dihydroxy-68-dimethylchromoneΪ2-ʮ2-n-tridecyl-2-ʮ2-n-pentadecyl-2-ʮ2-n-heptadecyl-2-ʮ2-n-nonadecyl2-ʮ2-n-pentacosyl-5,7-ǻ-68-׻ɫͪ57-dihydroxy-68-dimethyl chromone

к-μ-μ-711-ȥμ711-dehydromatrine-5a9a-ǻμ5a9a-dihydroxymatrine-N---9a-ǻ--N-ȶlupanine--͵Ҷ-N-׻ȸ-ҶҰ-rhombifoline-Ҷmamanine-ΰkuraranineΰisokuraramine

ҩá1.ãμпԣСǻע500μg.d2moΪ40%23ȫμԴáμнСǻϸP815ϸֳЧӦSophocarpineпԣʵСڶS-180U-14.ECALԵáμμ䲻ͬϵABCS-180ʵв̶ͬȵãʾ35%ϣͬϵC113mgkg·dʱǻעҩ10ʴ61.38%ܼ23.5%뵥μȣŲ죨P0.01μϸѪܶѪϸŵãʴ0.76ŨΪ100mgLˮҺѪϸڼΪ8mgmlʱŵյѪϸ򵥺˾ϸֻ

2.ϸãμɷֹСMMCСϸ֢עע30mg/kgܼ100mgkgμѪϸԵãμõЧʱ䡢άʱͰϸֵܼȣڸҩ18ڻһµģЧδڿܼμμԼX600İϸ֢ʵУܼӸҩ5󵽵l9죬ϸ6000mm3ϣֱ22ŻָˮƽμЧ۲ܼμδЧμԼþ60r-500ȫİϸ֢Ϊ31ףminʾһãڼΪ120ףmin޷á

3.Ѫϵͳã1/4LD50ĿμμעŶԿͷȷ-շĴʧǻעŶԿȷշС˲ҲͷշʧԿȻշĴʧͽǰ֧շʧþע30mgkgμշʧָʱ䣬Ƹҩƽ43%Ԥҩƽ22%ע42mgkgɶԿȻշСʧͷշĴʧעl6mgkg۰粫ͣҲܶԿ-ٹշȮʧܶԿȻ-շС󷿲ˣȷ-շʧעl5 LD50Ļ11mgkgԤͷշĴɷ򳣣Ҳ۰ʧֹȻȻշʧ1/10 LD505mg/kgʧʱ䣬óʱԶϿᶡҲҵ²ֵ澲עߣܼصؽȷ»Ȼ̼շСҲʣԼԿȻ̼-ʧѪܺͶԼļȱѪıáÿԵĽѹãһ㽵ѹ20mmHgң2-3ӻָöѪţҳ10ңԼʧѪӳͣʱ䣬ӳʱΪ7ңԴҶ¼ļȱѪԵıáμķõ-Чϵ9μmӰļ˷ԣ̹ܲӦڣշķԵŨȣķԶɣCaCl2ķƵáж360μmɽļ˷ԡμ50μmol/L׿صƵáμ100μmol/LļϸϵͣߣŨȿʹαβ鵼ƵáμɼҷԶƵʣҷͽMDFƵʣʼϵ为ƵʣԼ͸MDFþֱءμͷշûӳͷշԶɵDZںͼʼƵʣҲ۰շҷʧעҺշԵŨȣ۰ԼǿЧӦμܱCa2+ͨͼάף1μmollƣƽļʾμÿ뼤Ca2+ͨйءμߴѪcAMPͽcMPˮƽļ֯cAMPcGMPӰ졣ߴѪcAMPˮƽļ֯cAMPμ50μmol/L250μmolL˿ùCļϸøŵãܼȱȱɵļϸˣȱµļϸޱáעμӳСֲļڵãӴǿܻͪ125-250μg/mlʱܼļϸԷƵʣܶԿļϸԷԼ۰շIJʧܻͪСȷ˲ԵĶԿãLD50Ϊ23.9±1.1gkgָΪ3.56þעܻͪ8g30gkg30-60ӺԶԿȷ-ʧȫԿʷֱΪ40%70%עܻͪ20-40gkgԾעͷ´ʧԵáһЧʴ63%ڶƵЧΪ84%עμŶԿͷȻͽµʧעܻͪ30gkg60gkgԵظãƵú͸ԴáЩӶǿ

4.ƽ̵ãμҪͨ˷β壬˷β壬֧ܾμƿӦʵͷŶƽõġμиƻ޸ƿӪҺУܶԿȻ˷󡢴ܺͳܵáܼμ鰷´ƽЧ백ƣ1Сʱƽʶ90%ϣ15%ңƽʱϣ6Сʱƽ55%ܼ80%ϡAch´ñȰǿƽÿͨ˷Եβ-áӺڷ֤Сθܼͪ0.8gkg̸á

5.ãܼ50-100mgkgСɻ400mgkgС󱻶ƣ100-200mgkgƹ¶СŷΪܼ25-40mgkg붬飨5mgkgãСʧ100-200mgkgܼԼǿ0.5mgkgѪƽСԷãܼ50-200mgkg븹ǻע¼ͱ20-25mgkgãС˯ֱƣǻע䣬40mgkgˮȩǻע䣬200mg/kgãżǿáԶԿ˷ܼǻע䣬4-6mgkg50mgkgµľ˶˷ܣܼʿĵµľʲ޶Կãʹ侪ǿ䶯ܼʹȵʹãмȺãʹٷʡ

6.ãμɽ͹ʵͷţΪƼ50%TϸֳŨΪ0.55-0.56mgmlIL-2ŨΪ0.1mgkg

7.ãμμ15 LD50¶С߹ܾááעμ150mgkg100mgkgԱƤӦãѪIgEγáǻעμ200mgkg·d21죬Сٷͱ̬Ӧбá

8.ãעμԶԿͶ͡Dz˽󣩺ͱᣨСշ֢ùθƤע䡢ע䡢ǻעͼעμעҺμãȻӡ50%״пҴµãԳɷΪͪKurarinone⣬μпãǿù൱пγãǿ

ԡμעڼãͬʱΣֹͣעܣ˷ܣԣΪΣºֹͣ侷εķϵڼ跴ĿԼõСΪ0.4gkgѪѪκԺáܽϴҩСԳ鴤˷󣻾עÿʼη岻Ѷ150mg/kgעʱѪѪѹ½Լ٣ԶжLD50ⶨһ¡ܻͪСעLD50Ϊ103.1±7.66gkgСע;עμLD50ֱΪ256.74±573.6mgkg144.2±22.8mgkgθͼעνСLD50ֱΪ14.5gkg14.4gkgСƤעνᾧLD50Ϊ571.2±48.8mgkgȮעμ200mgkgνࣨ0.1gkg뼡ע100mgkgδж֢״α˨С޴̼ԡ

lȡƷƬҺΣ˨ƤʳȺɫѪɫòʧľʲɫӦɫأ2Ʒĩ0.5g115mlˮԡ10min˹ȡҺ3֧СԹУֱ⻯ء⻯ؼ⻯صԼ3ȡƷĩ0.5gӼ״10mlȻ10min˹ȡҺlmlԹУþ3-4ΣȣԺɫȡҺ5μlֽϣ5ҴҺɣƣ254nm¹۲죬Իɫӫ⡣ͪ4ɫ ȡƷĩ0.5gȷ25mlŨҺ0.3mlùҹ˹Һɣȷ0.5mlʹܽ⣬ΪƷҺȡȻμͻƷҴƳÿlml0.2mgĻҺΪƷҺȡҺ4μlֱͬһ2ҺƱĹ轺GϣԱ-ͪ-״83O.5ΪչչչԼ8cmȡɣԼױ--״-ˮ242110·úϲҺΪչչչ1ͬȡɣԵ⻯ؼҺҴҺ

ƷɫУƷɫӦλϣͬɫߵ㡣

Ʒʱ־л񹲺͹ҩ䡷1995涨ƷԿμ㣬2.0

ơʣȥоϴˮݣ̳͸ƬɹɣŴŨ֭һޣȻˮϸԹɹϸ֮

ζζࣻԺ

龭Σ󳦣Сףľ

Ρʪɱ档ʪкѪ㣻С㲻ˮף£Ѣ磻Ƥʪ

÷ڷ3-10g衢ɢãˮѬϴĩ󣻻롣

ע⡿1.Ƣθ麮߼ɷ

2.ҽѧšθá

3.ݾ衷÷Ρ޴

1.岹šΣܾ֮ߣҲ֮νҲδйϸ

2.ݸĿΡư֮ຮܲȡʪҲ磬ʪ棬ηɱ档Ωˮʤ֮ˣ˥䣬Ԫ㣬֮˲ҲŴƣҩԶҲʲݡΣɲν֮÷ζ࣬ƫʤ֮ҩȻѧߵ֮ҲʳȻְʷǡƣֹ̫ҽȣݣԿ磬塢ȡȥʪɱ֮塣

3.ݻԡҦ쳳ƣΣкʪȥ֮ҩҲǰνβǴҩζȣ֮ѷΩʵʪʤ֮˥䣬Ԫ㣬֮ˣθҲо÷ߣרʵ֮νҲв֮

4.ݾ¼Σרľ֮ȥ֮Ϊ࣬ȥĸС֮Ϊ࣬Ի֮ζ壬֮ζҲж֣ȡƢ֮Ҳ

5.ɳҩ⡷ѡκʴ²ߣԸǰڽۣ֮ʪľݣΪȣNIʴǰȶȥʪƴɱҲ鱴ĸ裬֮Сѣʪľݣȣйˮȴף±ѣʪȶͨɬҲ

6.塷Σ󺮣йʪ书Чˡ֮ңɱʪ֮棬֮ˡҡ˲Dzηζѷ֮ҲȻ񮣬Ǵ˲˵Ϊϴ֮ãδҭʳ

7.ũݾĸ֢ۣ㣬ˮӸףУĿֹᡣ

8.ҽ¼ε࣬־澫ϣȳݣֹʣѾƣСƳ࣬ƶ²ƽθʳ

9.պ뾰˾֮߷ɱ档

10.ҩۡȶ磬Ƥüѣ˯θʹжʹƣĸۡ

11.Ʊݡᣬƶ档

12.ջӱݡɱ档̳Ϊĩ£γѪ

13.ҡȥʪ

14.ϱݡѪȶ񮣬ŧ񽴯ƤѪѢƤмѪѪ磬׶̵

15.ݴ¡ʪʤȣŻ

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