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ҽҩȫ > ҩ > ҩ > K > Ƥ

Ƥ

2017-06-23 15:08 Ķ:

ȫвҩࡷƤ

ҩơƤ

ƴK Liàn Pí

ӢCORTEX MELIAE

鬡ӡɭϻƤ

ԴƷΪ鬿ֲMelia toosendan sieb .et Zucc. Melia azedarach L.ĸƤƤȡɹɣȥƤɹɡ

״ƷʲƬ״״Ͳ״һ26mmɫҺɫֲڣн֯Ƽ״ɫƤףȥƤߵɫڱɫ򵭻ɫͣ۶ϣάԣʲƬ״װ롣޳ζࡣ

𡿣1ȡƷһΣ۵꣬ɷΪ㱡Ƭư䣬ÿ㱡Ƭмϸơ

2ȡƷĩԼ1g10ml2 Сʱʱʱҡ˹ȡҺ 1mlӸɺ󣬵μӶԶװȩҺΣԺɫȡҺ 1mlԹУӸɺ󣬼Ӵ 1ml裬عܱڼΣɫԺɫϺɫ

3ȡƷĩ2gӱͪ25ml25ӣ˹ҺɣӼ״1mlʹܽ⣬ΪƷҺȡƤҩ2gͬƳɶҩҺձɫ׷¼ B飬ȡҺ5μlֱͬһ轺GϣԱ-ͪ401Ϊչչȡɣƣ365nm¼ӡƷɫУҩɫӦλϣͬɫӫߵ㡣

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龭ΡƢθ

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÷4.59gĩ֬󻼴

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ժ¼ȫвҩࡷ


ҩǵ䡷Ƥ

ҩơƤ

ƴK Liàn Pí

Ƥŷ鬸ľƤĿ˫ƤϾҩݡ

֤౾ݡ

ԴΪ鬿ֲƤƤʱɲɣԴĩijΪˡɻڳȡƤƤϴɹɡ

ԭ̬ٿ鬣֤౾ݡϻɭɭ

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ڸƤлئ顢β-޴Ǻ΢ɷ֡

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ձ鬵Ĺʵ͹ƤУõͪ⣬ͪȥʵȡ

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ܡϱݡ"ƤɱС׳档"

ݡҽҪ"ɱᡢξҡ"

ޡִʵҩ"Ƥг桢׳桢ͳ涼Ч"

ߡҩ־"ζ"

÷ڷ23Ǯ12衢ɢãˮϴĩ

ע⡿Ƣθ麮߼ɷ

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ԴҩĻԴΪ鬿ֲ鬺ʹ鬵ƤƤ

ֲﶯ1.Melia azedarach L.2.Melia toosendan Sieb.et Zucc.

պʹأȫ򴺡^գȡƤƤȥɳɹɡ

ԭ̬1. Ҷľ15-20mƤɫѣ֦ɫжϸСƤס״ҶСҶԲΣ3-7cm2-3cmȶ˳⣬ШλԲΣԵжۼݣɫ浭ɫʱ״ëԺҶаë⣬ëԲ׶ҸɫԼ1cm5ѣƬΣë5ƽչΣͨɫԼ7mmӷλ˹ԲλΣ1.5-2cmɫ4-5ңÿҾ1ӡ4-5£10-11¡

2. ľߴ10mƤҺɫ۲ܱ״Ƭ״ҶԼ35cmƬ4-5ԣСҶλխΣ4-10cm2-4cmȫԵݡԲ׶ҸɫƬ5-65-6ɫ1012˿Ͳ˹ԲλΣԼ3cmɫɫƤΪӲľʣ⣬6-8ңӳԲΣƽ3-4£9-11¡

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2.ں500-2100mľֺڻƽӡشʪ󴦣ڴԸ·ߡ

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2.ֲڸࡢϡϡĴݡϵȵء

ࡿ1 ѧϲůʪͺͼ񤱡ӦԽǿϲɷ֡ˮáֳʵɰΪˡ

༼ ӷֳԷ10-11ѡ20ϵв֡4²ǰˮ4-5dо30-45cm6cmӲ𣬸ѹʵ1꣬괺ԡ5m×5mѨѨ1.2m80cmײʩǷʣϸϸ10cmÿѨ1꣬ʱҪʹչܽӣѹʵˮ

ֺÿҪݡʩ2-3Σ꼾Ҫʱųˮ

溦 񲡡ְ߲ԼҶҶ߲溦лƴ̶ꡢ̶ꡢţȡ

2.ѧ ϲůʪϲΣں1000m¾ѡ㣬ɷֵɰΪˡ

༼ ӷֳԷ11-12²ժdzɫʵ֣ˮ2-3dȥ⣬ȡˣɣʪɳشѿ2Ѯ3Ѯ֡о30cmṵԼ6cm12cmÿѨŹ1ö漴ʩϡˮ8-10cm1ҳ磬ÿö˿ɳ3-5ꡣ10-15cmʱи1Σʩ˷18-20cmʱе2иݡ1꣬ڶ2괺ѿǰԡࣨ2.5-3.5cm ×2.5-3.5cmѨÿѨ1꣬ѹʵˮ

Ҫǿɻÿ괺^иݣ׷ʣ֦ʱˮ

״״ ƤʲƬ״״Ͳ״һ3-7mmֲڣɫҺɫн֯Ƽ״ɫƤסȥƤߵɫڱɫ򵭻ɫͣ۶ϣάԣʲƬ״װɱƬư䣬ÿ㱡Ƭɼϸơ޳ζࡣƤʲƬ״1-5mmɫɫ΢й󣬴ֲڣơƤƤϸɼƤ׵ƤΪѡƤƤȥ˨ƤΪѡ

΢ Ƥ棺3-4ľ˨֯ľ˨㳣뵽ƤƤѲƤ㡣Ƥӳά뱡֯гɲ㣻άΧıϸкƷγɾάֱ6-31μmάںľΣڴϸвƴؾϸкԲΡԲλԲΣλ2-5ɵĸƤ档ƤϺڲɼ߼ǷɸȺľ˨Ϊľ˨ϸƤƤ߲״3-5ϸƤάгɶĻ㣬άΧϸƷγɾάƷϸеĺƷ

ĩɫάֱ15-27μmڼľάΧϸƷγɾάϸڲľ񣬺Լ14μmλΣֱ13-29μmľƤϸάԣ೤ΡλԲΣ43-130μmֱ15-37μmԺ΢ľϡƿס⣬ľ˨֯ƬеĺɫֱԼ13μmϡдؾ

ѧɷ֡1Ƥкдأtoosendaninͪkulinoneͪkulactoneƴkulo-lactoneֲmethylkulonatemelianotriol-3-O-β-O-D-߰7a-acetoxy-l4β15β-epoxy-gedunan-1-ene-3-O-β-Dglucopyranoside18-ǻ-2-׻-3-O-β-D-૰߰18-dihydroxy-2-methylanthraquinone-3-O-β-D-galactopyranoside15-ǻ-8--2-׻-3-O-a-L-߰15-dihydroxy-8-metho-xy-2-methylanthraquinone-3-O-a-L-rhamnopyranoside45-ǻͪ-7-O-a-L-ǻ-1→4-β-D-߰4’5-dihydroxyflavone-7-O-a-L-rhamnopyranosyl-l→4-β-D-glucopyranosideݣ촨أisotoosendaninβ-޴β-sitosterolʮ鼰ˮԳɷ֡ľкӡ鬲飨nimbolinABƤͪfraxinellonegedu-ninк۲-5-O-β-D-૰߰apigenin-5O-β-D-galactopyranoside

2Ƥء촨أƤĴصĺƤеԸߡ

ҩá1ãҩȡ׳áõЧɷΪأҴȡǿŨȣ15000-9000Ĵأ׳漰ڶΣͷвԵ˷ãΪԷǿЪس쳣ľƻ˶Ĺԣǿཻ棩10-24Сʱת뾷͸Ƥֱڻ׳漡⣬лƣͶΡŨȵĴԻ׳-˷òƷϣʾز⵨ҩŨȣl1000Ĵض׳رͷ񾭽áãdzҩúʼЪԾĽAmmonϺֱⶨȽĵøͺͽ⣬֤Ӱ죬زͨǴлáӻ׳漡еATP޻׵ʵпԿʹATPķֽлӿ죬Ӷɻ׳Ӧȱƣͣų⡣ŨȵĿƤҩҺ25%-50%СͳҲá

2ԺӰ죺Ĵأÿֻ󣬾ע2mg˥ߡҪڸóɷֶáԺಿλֱӸ质أÿֻ0.10-0.15mg֧˷ҩɲ׶Դĺ΢ĶԿá

3񾭼⴫ݹܵӰ죺ضԴвӴ̼ļӰ񾭵˷ܴҲͼֱӴ̼ķӦ1ѡԵͻǰ񾭼⴫ϼòλͻǰĩң÷ʽƴ̼շͷš΢۲ضС񾭼ͷ΢ṹԵãͻ϶ӺͻĿ١ֱ仯ͬʱͬһͷ

4ⶾжضⶾжáAⶾжСж6Сʱ质أãAⶾжĺӣж24Сʱ质أ϶BⶾжС󣬴Ҳбá⣬ǿѪⶾжСͼõá

5ͷͻеԵӰ죺ŨԵʹ췴Ӧλ90%ʱ̣APD 90ӳȻIk1ȡӳAPD90ãʹӦeAPDӳFCǿȻ󣬿ȡصãӳAPDôڡ⣬ؿʹ쳣lСʱԶָ

6ãأ200mgkgùθԼŨΪ0.2×10-4mgĴؾλüóӡŨΪ0.2×l0-3mgĴʹ־˷ܱԿƷϡ10%ƤˮҺԶ²á鬸ƤȡСʵѪ没Ӷڴȷ֤ʵһЧ

ԡСǻƤºͿڷİֱΪ13.8 ± 1.2mg/kg14.6 ±0.9mgkg14.3 ±1.5mgkg244.2±44.0mgkgƤעͼþעİֱΪ9.8mgkg4.2mgkgضθд̼ԣ̶죬ڷغ󣬴θճĤˮס֢񣬲ȮŻ¡Ȯáϸͱԡ񼼫խСѪALTߣأQжԭѪͨ͸ӣѪѪѹ½γɼѭ˥ߡСԶԵİΪ18.7mg/kgϵΪ1.13ǿҩǼжԵıALTߣǼʷ֣Ķв̶ͬȵѪ΢췢֣СѪĤػɫҼԽԽࡣϸͣɣɼݷϸɿѪųѪѪƤϸͣϸСѪΧ϶ӡ

ȡƷĩԼ1g10ml2hʱʱҡ˹ȡ˲1mlӸɺ󣬵μӶԶװȩҺΣԺɫȡҺ1mlԹУӸɺ󣬼Ӵ1ml裬عܱڼΣвɫԺɫϺɫࣩ

ơ1.ʥݷ"ﱡ"2.÷"ϸС"3.ŷ"ȥߣΪĩ"4."ȥƤ"5.ҽѧĿ"ȥƤ"6.ȫ顷"ȥƤ"7.ȫ"ȥƤȡ⡣"Уȡԭҩģȥʣϴ͸˿ Ƭ״μ"ҩļ" ڣﴦù

ζࣻж

龭Ƣθξ

Ρɱ棻Ѣ׳没没ͳ没γ没괯ͷѢ

÷ڷ6-15gƷ15-30g衢ɢãˮϴĩ

ע⡿ϰߡиƢθ麮߾಻˳͹áƤһĶӦҩжͷʹͷΡġ¡ʹ֢״жɳѪжԸסʧԣݿˡ

1ޱݡ“֣дơ߸ж֮ʹ²ֹʱߡ߸΢õȡߡ”2ҩ־“鬸ƤЧһĶԣӦϻߵ䡢ʵͶҩ”

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