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ҽҩȫ > ҩ > ҩ > N > Ů

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2017-05-14 17:20 Ķ:

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ӢFRUCTUS LIGUSTRI LUCIDI

顢[ӱա]

ԴƷΪľϬֲŮLigustrum lucidum Ait. ĸʵʵʱգȥ֦Ҷ÷ˮ̺󣬸ֱӸ

עֲͬŮLigustrum thibeticum Decne.ʵҲŮҩЧơ

ԭ̴̬ľľߴ10סֱƤɫ⻬ѣ֦չƽëƤסҶ״ΡļɫСԲ׶㣬ܼ޹״˹ԲΣһ͹Լ1ףʱɫ

״ƷΡԲλΣ68.5mmֱ3.55.5mmɫҺɫƽйۻ༰̹ᡣƤйƤװ룬ڹƤľʣɫ⣬ƿͨΪ1ΣϺɫԡ޳ζʡ΢ɬ

ȡƷĩ0.5gӼ״20mlȻ30ӣ˹ҺɣˮҴ-ȷ£3:2Һ1mlʹܽ⣬ΪƷҺȡչƷҴƳÿ1ml1mgҺΪƷҺձɫ׷¼ B飬ȡƷҺ35μlƷҺ5μlֱͬһ轺GϣԻ-ͪ-5:2:1Ϊչչȡɣ10ҴҺ110ߵɫƷɫУƷɫӦλϣͬɫİߵ㡣

ơŮȡ𾻵ŮûƾưȣڻڣϣٷˮĹڣƱȡɣÿ100ûƾ20

Ů𾻵ŮӷڻϣٷڼˮĹڣ͸ȡɡ

ζʡ࣬

龭Ρ

Ρ̲Ŀڷѣζϥ뷢ףĿ

÷612g

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ƴN Zhn Z

Ůʵӣüɷ飨ҩԡӣҩԾ𷨡ӣҩ־

ԴΪľϬֲŮʵʵʱժȥ֦Ҷɹɣ򽫹ʵѬɹɣˮ̹ɹɡ

ԭ̬Ů꣨ľɽŮľࡢĿСҶࣨҽҪٰͼˮֲʵͼˮ㡢Ҷˮ塢

̴ľСľߴ10סƤɫdzҺɫ֦⻬ƤסҶҶ12ףвۣҶƬʣ״Σ514ף3.56ףȶ˽⣬ШΣȫԵɫй浭ɫܲϸС͸ٵ㣬ԡԲ׶1015ףֱ817ףܻԼ4ףޣƬҶ״״Σޱ䣬С״ΣС̻ޣ״Լ1.5ף4dzѣڹԼƬȳƬ4ΣԼ2ףɫ2ڻڹܺ˿ϸ⣻1ӷλΣ2ңԲ״ͷdz2ѡ״˹ԲΣ612ףʱɫʱɫ12öԲΡ67¡812¡

ֲɽҰֲͥ԰ֲϡϼиء㽭աϡԼĴȵء

״ʵγԲΣе΢510ףֱ34סƤɫƣ˶Բײйۡʼᣬᣬƿ󲿷ΪʣΪ˫ʣмиȿֿԲΣ˼⣬ϺɫҰɫ޳ζʶ΢ɬ󡢱ɫڣʼʵΪѡ

ѧɷ֡Ů߰nuzhenide魿߰oleuropeinչᣨoleanolic acid4-ǻ-B-һ-B-D-߰ľbetulinȡ

ơŮӣȥʣϴɹɡŮӣȡŮӣӻƾȣùڻڣܱգˮУˮȡÿŮ100ûƾ20

䱾ݡ"ŮϴȥƤ£ưɹɡˮ賴ɡ"

ζʡƽ

١"ζ࣬ƽ"

ڡ¼"ʣ޶"

龭Ρ

١ݾ衷""

ڡ¡"ΡΡ"

ΡǿϥȣͷΣĿϥ뷢ס̲Ŀڷѣζϥ뷢סĿ

١"У࣬񣬳ټ÷ʽ"

ڡܡ"ڷ룬ǿǿѪȥ硣"

ۡĿ"ǿϥĿ"

ܡݾ衷"ѪѪ"

ݡ"ƽ𣬽ⷳȹֹ麹ʣǣ©ѪѪ©ʹλ𣬿Ŀֹᡣ"

ۡ¡"ΡۣͨѪ"

ߡҩ־"˴ء"

÷ڷ1.53Ǯãۡ

ע⡿Ƣθ麮йк߼ɷ

ݾ衷"ӱƢθҩů֮ͬʩиʹй֮"

ٲϥ׳ǣǿڷŮӣղɣж٣ɣ۾ưһҹִȥƤɹΪĩƿȰɣãݣղɣж٣֭࣬ǰҩΪ裬ԾƷҽ⡷裩

˥ŮӡɣǮһˮŮӶ׾ƶÿ㽭䳣òҩ

ηȳۣӲԶ٣֭࣬ƿչ̣գÿõۡüɷ

ףŮӡݾӸһˮ㽭䳣òҩ

ߣԳȵȣŮǮعƤǮһǮ֣ĿݲݶǮ.ˮ壬һطִַʵҩ

ȣʹΪŮǮǮǮ顢ߡʯۡZţϥǰӸǮ󵭲öˮҽʤ塷Ů

߲ȡŮӣȥҶһҹȥƤɹɣΪĩݳʱʯ֭ŨĩӣӴÿҹ裬¡ʮ֮ӣ˲ҹܱ׷ΪɫǿϥַóպɵŮʵƽһգ͸ɹɣȡһļղɵĺݣȡʮղɵɣӣȡʮζΪĩӴÿߡֱ裬;·ݲɵɣ驣·ݲɵĺֱӵ֭ҩüۡ

ȳۡŮӲ֭࣬ƿմ棬պȡԵۡ

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ƴN Zhn Z

Ůʵӡ顢ӡ

ԡĿŮꡢࡢ۹ҲŮ꼴׺ߣ༴׺ߣ۹Ǽ׺èߡŮïʢΪ࣬붬ͬһֶֽ׳Ҷ᳤ɫ౳ŮҶġ磬ӺɫҶ΢ԲӺɫΪ졣仨ԷӲϲʳ֮ľ԰塣˲֪Ů꣬Ϊ

ԴҩĻԴΪľϬֲŮĹʵ

ֲﶯLigustrum lucidum Ait.

պʹأŮԺ45꿪ʼÿ12¹ʵڶа׷ʱ£ȥҶʣɹɻˮ̹ɹɡ

ԭ̬̹ľľ߿ɴ25mƤҺɫ֦ƺɫɫϺɫԲΣԲλԲƤסҶҶ1-3cm߹ҶƬʣΡλԲԲΣ6-17cm3-8cmȶۣԲΣʱШλԲ׶8-20cm8-25cm;򹣳3cmƬҶͬͣСƬλΣ䣻޹޹ë1.5-2mmݲԻΣڳ4-5mmƬ2-2.5mm,ۣ˿1.5-3mmҩԲΣ1-1.5mm1.5-2mmͷ״λΣ7-10mm4-6mmɫʱʺɫ׷ۡ5-7£75¡

ֲ̬ں2900mµֻУͥԺ·ԡ

Դֲֲ༰ϸء

ࡿѧ ϲůʪϲ񣬲ͺ

ԴȾĿԽǿԶ⼰ǦнǿԣҲܽϸߵķ۳̳ȾҪϣɰϻճΪˣں졢

༼ ӷֳҲǤ塣ĩʵʱ£ȡӣ漴磬紲13mľ03mṵԼ1cm10cmȲ幵ڣʩϡ࣬ٸϸÿ1hm2300375kgÿи4Σ46811½У4º11иݺ׷ʩˮ1Σ2ԡ45£3m×3mҿѨÿѨ1ꡣ

Ժÿ410¸1Ρ׷ʩ12ΡΪۺãϷ档

溦 溦ţ׳Ϊɣպ590аٳҺ׶ɱ

״״ ʵΡԲλΣ6-85mmֱ35-55mmɫغɫƽйۻ༰̹ƤйƤԺڹƤľʣɫ⣬ƿͨ1ԲΣһƽ΢Ϻɫԡ΢ζ΢ᣬɬ

󡢱ɫΪѡ

΢ ʵ棺ƤΪ1ϸڼڼӺڳ͵ΡйƤΪ12-25бϸڹƤ7-12άɢڡڹƤΪ4-8ά⻷ƤΪ1ӳıƤϸ68-108μm60-80μm͵ΡΪϸɫϺҶ

1ȡĩԼ05gҴ5mlҡ5min˹ȡҺɣμȻȷ±Һɣɫࣩ2ȡĩ1gҴ3mlҡ5min˹ҺУɣӴ1mlʹܽ⣬1ΣҺɫ̱Ϻɫɫƣ365nm¹۲죬Իɫӫ⡣߰ 3ɫ ȡƷĩ5g7Ҵ-ˮ13Һ50mlȻ2hȷҡȡ3Σ50ml25ml25mlȷҺˮҡϴӺˮˮ˹ȷҺɣԼ״1mlܽҺȡչȷҺҺֱڹ轺Gൺϣȷ-ѣ11չ20ᣬ105濾ɫƷɫƷɫӦλͬɫİߵ㡣

ѧɷ֡ʵչᣨoleanolic acidչᣨacetyloleanolic acidܹᣨursolic acidܹᣨacetylursolic acid-ǻҴphydroxyphenethyl alcohol34-ǻҴ3 4dihydroxyphenethyl alcoholβ-޴β-sitosterol¶mannitol-ʥأeriodictyol-أtaxifolinƤأquercetinŮ߰ligustroside10-ǻŮ߰10hydroxy ligustrosideŮ߰nuezhenide魿߰oleuropein 10-ǻ魿߰10hydroxy oleu-ropein-ǻһ-β-D-߰phydroxyphen-ethyl-β-D-glucoside34-ǻһ-β-߰34-dihydrox-yphenethyl-β-D-glucoside׻-α-D-૰߰methylαD-galactopyranoside߰acteoside[1]Ů߰neonuezhenideŮ߰ᣨligustrosidic acid魿߰ᣨoleuropeinic acidΪGI-3ѻϩ߰[2]ǣǣǣɵĶ[3]Ϊ0397֬໯֬phosphatidyl cholineߣռ5652±1.34[4]мءơþơп̡ͭ11Ԫأͭп̡Ϊ΢Ԫ[5]

ŮӺŮᣨligustrinṹΪ廷ᣬ߼ãŮ꺬8-߰8epikingiside

ҩá1.Ѫ֬Ӳ ŮӴַ20g/ֻʳιǣʵԸѪ֢֬ÿɽѪ嵨޴ʹ֬ʰ߿鼰״߿γŮӳɷչ30mg/kgιǴ0.4%չҺ0.5mlùθԸѪ֢֬þнѪ֬áչ3060mg/kgιձ8ܣԽѪܵ޴֬ʡܵ޴ͶӲķʡ

2.Ѫ չ50100mg/kgƤע䣬7գɽСѪǣСԤãҲܶԿػСѪߡ

3. չ3050100mg/kgƤע䣬Ȼ̼ĴѪȱתø(SGPT)ߣδȻ̼Ĵչ50100mg/kgƤע䣬ҲʹSGPT½չ70mg/kgƤע䣬ɼȻ̼ɵĸˣ֯ѧ۲죬ϸݱԡɱԡϸСҶ֢ӦĶᡣչ2mg/ֻƤע䣬6-9ܣԸ֬ʳPȻ̼ɵĴӲзá羵۲Ȼ̼˴չ20mg/ֻƤע䣬ʹϸݱᡣ

4. Ի߹ܵӰ4.1 ԷߵӰ4.1.1ܰϸ ŮܰϸĿЧɷΪչᡣȡܻ(cy)Сϸ١Ů480mg/kgСϸӰ죬ɾǿ(25mg/kgip)°ϸ½

4.1.2״ƤϵͳɹܵӰ ͨѪҺٶȣ۲ϸigŮ240mg/kgx5dСivָ̼ǿ״ƤϵͳĻԣŮ480mg/kgòԡŮӼ12.5g/kgx7dָӰ죬25g/kgx7d״Ƥϵͳɻԡ

4.2.ߵӰ4.2.1ϸ߹ܵӰ ŮTܰϸܡŮӵˮ0.02mlǿPHACOAPWMܰϸֳԵǿ()ܰϸĴֲֲӦ(GUH)ڲֵͨTϸöʵֵġŮӶ(LLPS)ʹСƢܰϸConAֳ̼Ӧǿ3H-TdRֵ(Cpm)10mg/kgҩ(39308.1±6208)϶(17959±4508)Լ120%P0.0150mg/kgҩ(2979±3625)϶Լ70%p0.07ŮӼSRBC³ٷͳӦдٽáŮӿǿϸ߹ܡչ40mg13Σ1-2£߹ܵãƤݷϸɹܺѪҺܰϸõ廨ߡ

ŮˮﻹǴMIL-1ãˮȴǿһʾŮӵߴٽÿM-IL-1йءͬʱŮͨǿϸĻԶٽTϸĻԣTsԹ߶߹ܵ£ŮӿǽϺõߵҩ

4.2.2Һ߹ܵӰ ŮӾǿҺ߹ܵáŮӼ7ig12.525g/kgʹ١ƢӣʹƢӡŮ240mg/kg480mg/kg×7տʹC57BLСƢࡢ١ǻܰͽᣬءŮӶÿע1Σ7100mg/kgʹLACAСƢ϶Լ40%50mg/kgʹСƢ϶Լ30%ŮӼСѪѪؿԣСѪIgGҶԿCyãŮӿԶԿǿãСѪIgGʹǿСIgGߣʾС徻ѪؿԣŮӶǶԿCy50mg/kgipɵĺС(S180)ܰϸֳӦƵãŮӶԶԿCyá

4.3Ա̬Ӧ ŮӼ12.525g/kgigС7d;ͬ5dig󣬲ͬŮӶС󱻶ƤӦ(PCA)ԵáŮӼܽʹ­ĤʴϸѿٷʣԿ鰷ĴƤëϸѪͨ͸ߣԭǰҩDNCBСӴƤףŮ25g/kgڿԭҩDNCBСӴƤͻ򱻶ArthusӦŮ20g/kgŽѪ岹˵ŮӶԢ񡢢򡢢ͱ̬Ӧá

5. öʵ֢ģ֤ʵŮ12.5g/kg25g/kgÿig5գԶױС͡СǻëϸѪͨ͸ӼʱDz˽塢ȩԴ;ãŮ20g/kg×3igŽʹ֢֯PGEͷŮ20g /kg×7տƴѿ֯ͬʱӡ俹׻ƿ漰¼棺ټһƤϵͳٽƤʼصͷţPGEĺϳɻͷšŮܽѪ岹ԣԿ֢鰷ĴƤëϸѪͨ͸ߣŮӵĿ׻ƿҲá

6.ͻ չС-180áŮӼ12.525g/kgθչ50100mg/kgƤע䣬Ի̹С΢á

7.ڷϵͳ оŮмдƼʣҲۼʴڣ߲ⶨŮӺغͪ428.31pg/gƶ139.02pg/g֤ŮӼغͪҲдƶļͬһҩ˫áŮӵȲҩСճĤϲ˴ƼãҩѳĴ࣬Ƽߡ

8.ѪϵͳӰ ŮӶԺϵѪдٽáӦɢѪ鷨ŮܴٽCFU-ECFU-E/5×l4Ϊ128.6±11.4(8)CFUһE/ɹΪ62040±5450(8)ɹCFU-ENSΪߣCFU-Dȴż١ҩСϸ̬ѧŮϵϸٷΪ47.3±2.99(6)NS37.3±2.86(6)ߣϵϸٷ37.6±3.96(6)NS46.6±6.26(6)٣ֵӦ仯

9.Ի̹Ⱦɫ˵ı ΢鷨֤Ůˮpol2.5g/kg25.0g/(kg.d)×6չih50mg/kg100mg/(kg·d)×7Իip50mg/(kg·d)×2̹500mg/(kg·d)×4ipСȾɫбãܽ΢ʡ

10.HpDȻ ŮܹԿHpDĹãӦܹԼHpDСƤӦŮ60mgҩ/mlԼHpD5ug/mlϲչ10minĺϸȩӣΪ57.7%ԶԿϸĤøƣԿΪ49.O%120mg/mlʱԿΪ53.3%СipHpD20mg/kgչ4hŮ20gҩ/kgip1ΣԼĹӦŮӶ1O2Чʱȶ3.5×10-4

11. ŮǿġŹ״ѪܡѪܵѪϵͳãֹȣкáչijЩǿġã¶лãжǣЩǿ׳йء

ԡŮӶԶﶾԺС1ηʳʵ75gж

ơŮӣȥʣϴɹɡŮӣȡŮ100ӻƾ20ȣùڻڣܱգˮУˮȡ䱾ݡŮϴȥƤ£ưɹɡˮ賴ɡ

ζʣࣻ

龭Σ

ΡȣĿͷĿѣϥž뷢ףȣĿ

÷ڷ6-15gãۡãá

ע⡿Ƣθ麮йк߼ɷݾ衷ӱƢθҩů֮ͬʩиʹй֮

ݾ衷ŮӣζȲ֮ҪƷò԰㣬ٲȥʽӡߣζʣΪܲҲҩбĿ֮飬IJأΪҲŮʵѪѪ……Σ£ΪȻҲ÷У֮ӡŮ̱֮ͬиۣζԹҲʱ£಻֮ӡ±ࡷŮʵ˶֮Ȼ΢Բ飬档ء轡󶬡ڡݡ֥顢ɽҩɣ驡ѻ١ͬã֮ҲȻΪ飬ŮӻйЧ֮٣ʵȡʤһʱ֮ʵã֮֮˶ԭŮ꣬ζƫƢθ˷֮ʳк۹Σдζ֮£Ůва֮ã̻֮У࣬񣬳ټ÷ʽܡڷ룬ǿǿѪȥ硣ĿǿϥĿݾ衷ѪѪƽ𣬽ⷳȹֹ麹ʣǣ©ѪѪ©ʹλ𣬿Ŀֹᡣ¡ΡۣͨѪҩ־˴ء

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