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2017-05-16 10:42 : Ķ:

йҩ䡷

ҩơ

ƴQiàn Co

ӢRADIX RUBIAE

١Ѫݡݡֳ߲ݡСѪ١Ѫ

ԴƷΪݿֲRubia cordifolia L. ĸڣȥɳ

״Ʒʽ״ϸȵĸԲΣ1025cmֱ0.21cmɫɫϸƼϸۣƤ䴦ʻƺɫʴ࣬۶ϣƽ̹ƤϺɫľ㣬dzƺɫܿ׶޳ζ΢࣬ýࡣ

𡿣1Ʒ棺ľ˨ϸ612УɫƤ㱡ϸеĺɫƤϸСγɲ㲻ԡľʲռҪ֣ȫľ߲ԡϸ뾧

2ȡƷĩ0.2g5ml,ҡӣ˹ҺҺ1mlҡʹֲ㣬ˮԺɫѲɫƣ365nm¹۲죬ɫӫ⡣

3ȡƷĩ0.5g׶ƿУӼ״10ml30ӣ˹ҺŨԼ1mlΪƷҺȡݶҩ0.5gͬƳɶҩҺȡҶضƷӼ״Ƴÿ1ml2.5mgҺΪƷҺձɫ׷¼ B飬ȡҺ5μlֱͬһȼ׻άΪϼĹ轺Gϣʯѣ6090棩-ͪ4:1Ϊչչȡɣƣ365nm¼ӡƷɫУҩĺͶƷɫӦλϣͬɫӫߵ㡣

ⶨոЧҺɫ׷¼ Dⶨ

ɫϵͳ ʮϹ轺Ϊ״-ˮ-߻ૣ310:90:3ΪࣻⲨΪ250nm۰ҶطӦ4000

ƷҺƱ ܳȡҶضƷӼ״Ƴÿ1ml80μgҺá

ƷҺƱ ȡƷĩԼ0.2gܳƶþ׶ƿУܼӼ״25mlƶݹҹ30ӣ䣬ٳƶü״ʧҡȣ˹ȡҺá

ⶨ ֱȡƷҺ빩ƷҺ5μlעҺɫǣⶨ,á

Ʒ㣬ҶأC17H15O40.40

ơȥʣϴ͸кƬΣ

̿ȡƬΣճ̿¼ D潹ɫ

ζ࣬

龭ξ

ΡѪֹѪͨѪѪ©˳Ѫ裬ؽڱʹʹ

÷69g

ءøﴦ

ժ¼йҩ䡷

ݵͼƬ

ҩǵ䡷

ҩơ

ƴQiàn Co

ֲݡСѪɽ

ԴΪݿֲRubia cordifolia L.^ڣȥɳɹɡ

ԭ̬ԮݱΣее̡Ҷ4Ƭ1Խϴ߳λ״Σ2.5~6cm1~3cmҶԵͱԴС̡ɡҸСݲԣɫɫ5ѣԵëʣСΣʱϺɫ9~10¡

ֲɽʯԻ򹵱߲ݴС΢ӱϡɽ

״ʲ״ϲо²ϸȵĸԲΣ״10~25cmֱ0.2~1cm,ɫɫϸƼϸۡʴ࣬ƽ̹ƤϺɫľdzƺɫ΢ζ΢ࡣԺζࡣ

ѧɷ֡ǻأalizarinأpurpuro-xanthinǻأpurpurinαǻأpseudopurpurinᣨmunjistin߰rubia,ruberythric acidؼѵȣַ׻Գɷ߰񼰢߰ԪΪᡣ

ζ࣬

龭ξ

ΡѪѪͨѪѪ©Ѫ˳Ѫ衢ؽڱʹʹѪֹѪѪƷֹѪ֤ѪոʹˡֹѪǿ

÷39ˡѪͨãֹѪ˳̿á

1ѪһĩÿǮˮ壬ۣˮĩǮɡ

2ŮաһƷ

3ѶѪѪΣݸҶ֣ˮɶ

4ѸءʯƤһѣӾһ룬߳ɣ·

ժ¼ҩǵ䡷


лݡ

ҩơ

ƴQiàn Co

˃¬éѡ˃㡢ѡ`ݡѪţ«㡢ѪɽľѪɳצ졢ӸӸСѪΡķӡǵ

Ƶھ"-˃"ҩء""ȷҩòΪ¼ָ"Ⱦ……ɽȡ"ݾע)ƣ"ȾҲж٣ࡣ"񱾲ݡԻ"Ⱦ糲ҶҶͷҶɬҶڼ䣬ӲݱϣϳɫУ²ɸ"Ŀν"ʮ磬ߡ

ԴҩĻԴΪݿֲݵĸ

ֲﶯRubia cordifolia L.[Rubia akane Nakai]

պʹأԺ2-3꣬11ȡϴɹɡ

ԭ̬ݣԮݱʮƤϺɫȺɫΣС̡ҶƬ߳ҶƬ״仯ϴΡ״ΡխΣ2-6cm1-4cmȶͨ⣬ΣֲڣҶе̣ȫԵ5ɡԲ׶״ҸСưɫ5಻ԣڷ״ֱԼ4mm5ѣƬ״Σȶ˼⣻5ڻڹϣӷλ2ңëΣֱ5-6mmɫתΪɫ6-9£8-10¡

ֲ̬ɽ·ԡءߡԼԵ

Դֲֲȫ󲿷ֵ

ࡿ1ѧԣϲůʪӦԽǿϡؾࡣԷֵɰΪˡ

2༼ڡǤ塢귱ֳ

21ӷֳ10ӳա10Ѯ3Ѯо30-50cmdzѹʵ

22Ǥ己ֳĴ2-3£ѡԲζδݵ٣3Լ33cmIJڼõĵϣ1.3m裬50cm×33cmѨԼ15-20cmÿѨ2-3¶棬ѹˮ

23귱ֳ11Ѯ3£ֲ𣬼ȥָҩ¸гÿѿ2-39cmСΣ35cm×30cm20cmѨÿѨ1꣬ѹʵˮ

330cmңӦ֧ϲͲˡ׼עϳݡȡʩҪʩʣԷֲͽ14Ѯ׷ʩʣ24ʩ1׷ʣ34ʩסطʡÿҪժᡣ

4溦Σи6-7·ʹ֦ҶήҶƬƣڸã𽥿ڣ2%ʯˮ˾50%ĿʪԷۼ600Һ䣻ְ߲7·ΪҶl1120Һɭп65%ʪԷۼ600Һ䡣׷۲ò0.5ʯϼ䡣溦档

״״𣺸ԲΣеϸиͷ10-30cmֱ0.1-0.5cmɫϸƼۣƤľ׷룬Ƥʻƺɫʴ࣬׶ϣƽ̹Ƥɫľۺɫڶϸס΢ζ΢ࡣ

΢𣺸棺ľ˨Ϊ6-10ϸϸƽӳɫں˨ڲΪ3-6ϸϸ뾧뾧ijƽСƤϸຬ뾧ľʲɵܡܰľάľϸɣֱ20-130μmľ˨㡢Ƥľʲ߾֮Ϊ114.5

ѧɷ֡1ݸ(alizarin)ǻ(purpurin)(purpuroxanthine xanthopurpurin)1-ǻ-2-׻(1-hydrox-2-methy1anthraquinone)1 4ǻ-6-׻( 14-dihydroxy-6-methylanthraquinone)ȥ׻ȩ(nordamnacanta1)ؼ(physcion)1-ǻ 2-(1-hydroxy-2-methoxyanthraquinone)14ǻ 2-׻-5-(8)-[14-dihvdroxy-2-methyl-5(or 8)-methoxyanthraquinone13--2-(13-dimethoxy-2-carboxyanthraquinone)1 3-ǻ-2-׻(13dihydroxy-2-methylanthraquinone rubiadin)1 3-ǻ-2-׻(13-hydroxy-2-ethoxymethylanthraquinone)2-׻-136.ǻ(2-methyl-136-trihydroxyanthraquinone)14-ǻ-2-ʻ(14-dihydroxy-2-carboethoxyanthraquinone)1-ǻ-2-Ȼ-3-(1-hydroxy-2-carboxy-3-methoxyanthraquinone)1-ǻ-2-׻-6(7)-[1-hydroxy-2-methyl-6 (or 7)-methoxyanthraquinone]13-ǻ-2-׻(13-dihydroxy2-methoxymethylanthraquinone)1--2-׻-3-ǻ(1-methox-2-methoxymethyl-3-hydroxyanthraquinone)4-ǻ-2-Ȼ(4-hydroxy-2-carbexyanthraquinone)14-ǻ-2-Ǽ׻(14-dihydrox-2-hydroxymethylanthraquinone )1-ǻ-2-Ǽ׻(1-hydroxy-2-hydroxymethylanthraqui-none)3--1-ǻ(3-carbomethoxy-1-hydroxyan-thraquinone)14-ǻ-2-׻(14-dihydrox-2-methy-lanthraquinone)(tectoquinone)12-ǻ-2-O-β-D-ľ(1→6)-β-D-߰[12-dihydroxyanthraquinone-2-O-β-D-xylosyl(1→6)-β-D-glucoside ruberythric acid]136-ǻ-2-׻-3-0-(6'-O-)-α--(1→2)-β-߰[136-trihydroxy-2-methylanthraquinone-3-0-(6'-O-acetyl)-α-rhamncoyl-(1→2)-β-glucoside]136-ǻ-׻-3-O-α-(1→2)-β-߰߰[136trihydrox-2-methylanthraquinone-3-O-α-rhamnosyl-(1→2)-β-glucoside]13-ǻ-2-Ǽ׻-3-O-ľ(1→6)-߰[13-dihydroxy-2-hy-droxymethylanthraquinone3-O-xylosyl(1→6)-glucoside lucidinprimevoroside]1--6-ǻ-2-׻-3-O-α-(1→4)-α-߰[1-acetoxyihydroxy-2-methylanthraquinone3-O-α-rhamnosyl(1→4)-α-glucoside]136-ǻ-2-׻-3-O-(6'-O-)-β-D-߰[136-trihydroxy-2-methylanthraquinone-3-O-(6'-O-aceiyl)-β-Dg1ucoside]13 6ǻ-2-׻-3-O-(3'-)-α-(1→2)߰[13 6-trihydroxy-2-methylanthraquinone3-O-(3'-O-acetyl)-α-rham-nosyl(1→2)glucoside]-3-O-β-D-߰(xanthop-urpurin-3-0-β-D-glucoside)

2Ҷ(mollu-gin rubimaillin)2--3--14-(2-car-bamoyl-3-methoxy-14-naphthoquinone)2--3-ǻ-14-(2-carbamoyL-3-hydroxy-14-naphthoquinone)ȥ-α-(dehydroα-lapachone)߻૴Ҷ(furomol1ugin)Ҷ(dihvdromollugin)(rubi1ac-tone)2'-Ҷ(2'-methoxymollugin)2'-ǻҶ(2'-hydroxymollugin) 1--2'-ǻҶ(1'-methoxy-2'-hydroxydihydromollugin)1'2'-ǻҶ(1'2'-dihydroxydihydromollugin)2-׻-3-ϩ-23--14-(2-carboxymethyL-3-prenyl-23-epoxy-14-naphthpeuinone)ëݾ(rubioncolin)

32--3-ϩ-14--˫-β-D-߰(2carbomeiboxy-3-prenyl-14-naphthohydroqunone-di-β-D-glucoside)3--2-(3'-ǻ)--14--1-0-β-D-߰[3-carbomethoxy-2-(3'-hydroxy)-isopentyl-14-naphthohydroquinone1-O-β-D-glucoside]ȡ߿õĻģ RA(rubiaakane)-񡢢򡢢󡢢[14][15][16]^[17]󡢢[18][19]

4ƻڹ(ru-biprasin)ABݰ(rubiarbenol)Dչ(oleanolic acid acetate)չȩ(oleanolic aldehvde ac-etate)6-߰(6-methoxygenipeidicacid)ݢ(scopo1eto1 scopo1etin)֬(fattyacids)β-޴(β-siiosterol)ܲ߰(daucOsterol)ȡ

5бк1.36-ǻ-2-׻-3-0-ľ(1→2)-(6'-0-)-߰[136-trihydroxy-2-methylan-thraquinOnes-3-0-xylosyl( l→2)-(6'-0-acetyl)-glucoside(rubiatriol)-Ҷ֬(iso1ariciresin-ol)

ҩá1.ֹѪãÿڷ½Һ2-4Сʱڣǻעּ֮ͬҺ30-60ӾԵĴٽѪҺáΪʱ䡢Ѫøԭʱ估ϲѪøʱ̡̿ڷҲСβѪʱ䡣ݻԵؾѪϰÿڷ½Һڿɲ־µĸʱ估ѪøʱӳѪʱ估ѪøʱֱΪ110롢45룻ע60Ӻ600룻ע½Һ(100%50ml)90mmע60ӺֱΪ18064롣Ϊˣݿػʹ³Ѫʵо֤ݺ㾫סױпãоεĿá㾫סױݶԵοۿýѪøʱΪ9.5룬12.5%λѪ50.8룬1%㾫34.8룬ӳ1.2롣ʾݵĴԡ

2.ѪСۼãԹڣҶضԻϩ(AA)ͽԭյļѪСۼкǿãɣ50ԼΪ86.6mmolLѪС弤(PAF)յľۼҲһԡ2-׻-136-ǻԽԭյѪСۼиǿãѪø AAPAFյԡ136.ǻ-2-׻-3-0-(3'-O-)-2-(1→2)-߰-3-0-β-D-߰ΪԭյѪСۼѡƼ

3.߰ϸãݵĴȡ߰ϸơ߰ϸЧɷ֮һΪ㻷ķ߰Чɷֵ˫˹ϳɡ˫С󡢴İϸãС󣺴οڷ2.5mg/ֻҩ8СʱϸߣҩΪ151.9%(P0.05)Ȯ1οڷ200mg/ֻҩ6Сʱϸӣ18-24Сʱ߷壬48-72Сʱ𽥻ָҩǰˮƽ˫дٽСѪϸֳͷֻãλ¹ϸ֢

4.ȷ̵ãˮȷӺڷֱ֤Сڷݸ75g/kgԵȺ̵ãҴҺЧ

5.ãݸˮȡҺԽɫһãԷи˾ͲƤҲáضԽɫҲá

6.ãݸĻ໯RA(rubiaakane)-V10mg/kg RA-4mg/kgǻע䣬5죬СܰϸѪP388ЧRA-VСܰͰѪL1210MM2ٰRA-СL1210B16ɫ᳦ٰColon38LewisΰϰԵĻԡСݸȡпԵĵRC-18ӳP388L1210B16СLewisΰS180áRC-18׵ʵʾ RC-18ܷչΪһЧĿ⣬2-̼-3-ϩ-23--14.Ͷ飬Բ(V79)ϸܰͰѪ(P388)˱ʰϸ(KB)пԡжСˮS180Ч

7.·ʯã20%(R.finctorum L)ƼιСֹܷʵͰ׽ʯγɣ̼ƽʯγáݸȡҺҺȶԣʯγɵΣԣһĽá

8.ʵļãԽ״ǰ֧˹ļģͣעòͬȡ200mg/kgÿ4СʱlΣ3ΣнS-Tε̧ߺСļΧáΪԡȡˮָܲСǻעԵļ֯ATPĺADPĴѪСۼнáļļȱѪбãʹļ˷ΧС˳̶ȼᣬӹ״

9.ƽãݸܶԿµóΣн⾷áˮȡӹ˷á

10.ãݸ½ҺܼѪܵá«ƣƴƤ֯ͨ͸ԡ

ԡСݸ150g/kgǻءض򾡢βʡţжԲ鶯˵޶ԡСڷ˫ۺ200mgκζԷӦǻע˫ҺİΪ3012.4±66.4mgkgڶԽÿտڷ˫5.4g/ֻ90죬δԷӦ9.6g/ֻԶԷӦ ݸȡɳž˺˾TA100TA98ͻãҪܻ(lucidin)¡

𡿱ɫף1ȡƷĩ(60Ŀ)50mgü״10mlݹҹ30ӣȡҺŨ1mláȡҶ߰߰Ҷ߰ҡҶ߰ΪƷֱڹ轺Gϣ-״-(410.1ˮ)չչ°ߵԻɫɫѬ󣬰ߵԺɫ(߰)2ȡƷĩ(60Ŀ)100mgü״10mlݹҹ30ӣȡҺŨͨС轺ʯ-(41)ϴѳɷ֣Ũ1mláȡǻءΪƷֱڹ轺6ϣñ--״-(310.20.1ˮ)չǻΪٻɫΪϺɫ

3ȡƷĩ(60Ŀ)50mgֽڣ70%Ҵ10mlݹҹ10ӣ˹ҺڣԼ״2mlܽ⹩áȡ߰߰ΪƷֱڹ轺Gϣȷ-״--(5.52.522)չ15%ˮҺ󣬴к濾߰Ϊɫ߰ΪɫΪٻɫ

ơ1.(׹)"ʹݸͭڻﱣոɣǦ"Ҫڷ"Ϊɢ"ʥ¼"顣"Уȡԭҩģȥʣϴ͸кƬΣɸȥмѪֹѪѪ

2.̿ʮҩ顷"ջҴԣмϸĩֽڵһϦ𶾡"УȡݶλƬùȣ潹ɫڲغɫˮ𾡻ǣȡٳˮݾȡɣ͸̿ԽͣԱɬֹѪǿ

3.ݡջӡ"ҩﱳá"УȡݶλƬùĻȣơ

4. "ϴ"䱾ݡ"ƳѪ"УȡƬƾưȣùĻ΢ȡɡÿƬ100kgûƾ25kg

5Ƭ״ݲμ"ҩļ"̿ƬΣʽɫڲغɫԾ߽ζࡣݣ潹ɫ糴ݣ΢߾ڣͨﴦܱգ̿ʱɢȣֹȼ

ζࣻΣľ

龭ΣģƢθİ

ΡѪֹѪѪѪȿѪѪѪѪѪ©գ踹ʹˣʪʹ㣻Ӹ

÷ڷ10-15g衢ɢơ

ע⡿Ƣθ麮

1.ݾע"ηá"2.ǩ"ͭ"3.ݾ衷"Ѫ֢йкʳߣ"4."鲻ѪƢá"5.ݻԡ"ѪߣƢθߣʤߣ֮"6.ݴ¡"߼Ͷ"7.桷"Ѫ鷢߼á"

ݣĿ:“ӱԶж٣࣬Ϊ硣”ݡݣΪ֮Ҳ磬`ƪ·ݲ:“`֮ò”νʢպ뾰Դ˲“”“`”ɳïʢѣ˵ġ:“ѣéѣ˃(һ«)ѪȾ筡”“Ѫ”˹֮˵ע:“ѪߣʹԴӹҲӅ`⡣éѡ«ԵҲ”«˵ġ“«”˵ġ:“㣬Ҳ”衷:“¿ӣ¿ϲ֮Ҳ”¿ã࣬“`”“”˃Ϊ«Ѫ”Ѫ”“Ѫ”ɻֹѪ֮ɫϳ࣬Ⱦ筣еѪȾ糲ݡɽţȣԮҶƬֲݡ糵֮Ŀ:“һڣÿҶ”(۲)ʳצҶ١Ҷе̣ӡݡճ

1.ݹûѪ11ʱ䣺"ݣͣζΣѪרѪѪ׷ŮӾˮͨһƷ֮һռͨЧ"(Ŀ)12ƣ"ݣжƶεˡѪøΣѪ飬ȱ©ֹʱŮͲУ˲ѪΣ֮󶼽ѪҩҲѪ֮Ѫܻ֮Һϸɿߣ֮ɻѪҩ֢Ӹߣ֮ŧҩЧԻΪӸߺΣѪ֮ΪҲô˼֮ѪжӸɢӡ"(ҩ))13禣"ݣɫѪ֣кѪزѪöУɢöѣܼѪ֮ƽֹ֮Ѫͨ"(ҽҪ·ҩԡ)14͢壺"ݣİѪΪ˴ˡѪѪѪкѪ֤ڴζνֹѪҲ"(ҩ桷)15ܣ"ݣΩѪͣԵѪ֤߶ҲѪ߶֮࣬"(ñ¼)2.ѪѪΪѪ֢֮Ҫҩ21ϣӺ"ݣѪѪ֮ҪҩҲǿ಻йȣǸʲԻѪ̲Ѫᣬ֮ͨУԼ㣬壬ΪΣָѪƣרʪҲѪѪѪУȥѪͣп֪ӡຮйֹڱѪȣסӵѪѪb԰޲֮Ѫ֮ѪιƶҩۡζķΣѪкѪջڡζֹǺ飬£ѪΣᣬ¾ֹŧδܣйѪѪȡѪѪຮй֮"(ݾ衷)22ɽף"ԺѪʧѪ֤֮Ž˵⣬塣ΣԺʪΪڣΪף޲ͬȻҩԴìܡ˱ع˴д֮壬Ϊָ͡ѪѪȣŲжԡݺѪͨ磬֮۱ԣȱһ򣬴˱زĺʪ֮νκԡʪҲ㱾֢ٴνָѪƣרʪȣ˵ǡȣˣΩȥȣѪе䲹򣬽ԵͨǷ֮

ٴӦáѪֳ֮Ѫ֤ԺѪ֣ѪֹѪܻѪ֮Ѫ֤ѡãˡѪȿѪѪѪѪ֤ߵã߿СéɽӵȣǿѪֹѪ֮硶ʮҩ顷ʮɢδ֮Ѫˡܡǵҩ峦ѪֹѪѪȱ©ءѻơҶҩѪֹ鲻㣬©²ֹߣ˻Ρɽ⡢ǵҩԲѪɬѡ Ѫգ踹ʹʹˣлѪ֮ѪѪգɵã䵤Ρ֡ҩͬãǿѪͨãΪѪݼ֮գֵڡػơܺȣѪѪͨβ踹ʹߣܽݡ١ֵҩȻֹʹߣܺڽҩɢůֹʹѪߣ˻˲ΡҩԲ黯εף컨ϡ鲹ҩԻѪˡ ڷʪʹݻѪͨηʪʹȱߣ̶١ʯ١ذҩֹͨʹ纮ʪߣֵ봨ڡٵͬãʪɢͨԡ ڻ㡣Ѫȶ˻ƣʪȻ㣬¡ɽ١ƵҩѪʪ˻ơ ڴӸסѪɢӸȶӸѹӢضҩ̴ʹơܵҩ

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