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2018-10-07 16:02 Ķ:

йҩ䡷

ҩơ

ƴQn Ho

ӢHERBA ARTEMISIAE ANNUAE

ӡϸҶϸ

ԴƷΪտֲƻArtemisia annua L.ĸϲ^ʢʱɸȥϾɡ

״ƷԲΣϲ֦3080cmֱ0.20.6cmɫػɫߣӲ۶ϣв衣Ҷɫɫ飬չƽΪ״ѣƬСƬԲλԲΣ汻ë죬ζ΢ࡣ

ȡƷĩ3gʯѣ6090棩50mlȻ1 Сʱ˹Һɣ30mlʹܽ⣬20Һȡ3 Σÿ10mlϲҺɣҴ05ml ʹܽ⣬ΪƷҺȡضƷҴƳÿ1ml1mgҺΪƷҺձɫ׷¼ B飬ȡҺ5μlֱͬһ轺DZϣʯѣ6090棩ѣ3:2 Ϊչչȡɣ10ҴҺ105 ߵɫƣ365nm ¼ӡƷɫУƷɫӦλϣͬɫӫߵ㡣

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ΡȽűаȣ鷢ȣҹȣűȣʪȻ㡣

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ƴQn Ho

ʫJëʫգݣĎfұݡҰִʵҩɽҩȾޣݡ

ԴΪտֲƻȫļǰѡҶɫߣȡϲ֣ɡ

ԭ̬˵ġ

һݱ30150ףȫƽëԲΣʱɫϸݲۣ²ľʻϲҶҸз֦Ҷ2״ȫѣ1ƬԲΣ2ƬΣȫԵÿ13״dzѣȶ˼⣬ᣬƽëɫͷ״г״Բ׶ÿһͷ״´ֱԼ6ףܰΣƬ34㣬İƬڲԲΣԵĤʣΧ״ƻڽ1öͷ2ѣڲΪԻ̻ɫڹ״5ö˿ϸ̣1ö˿״ͷ2ѣʲ״ݹԲԲΣ΢Сɫ67¡910¡

ںӰɰؼߡֲӱɽɽգա㽭㶫ȵء

ڻƻ"ƻ"

ֲĸʵӣ๩ҩãר

ֲȫ󲿷ֵ

״ĸȫݣԼ6090סԲΣɫ̺ɫĹƼߣȫëᣬ۶ϣά״ưɫаɫɵ衣ҶƬ䣬дҶ̺ɫʴ顣㣬ζ΢ࡣۡɫ̡Ϊѡ

ڻƻĸȫ"ƻ"

ѧɷ֡ﺬпζʡӷͺάA

ҩáˮ13ԹڶijЩƤЩáҴȡԹڶԹĿŨΪ7.8ˣЧ̡ưءƣڻ֦ݡ

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ڡ"ζ΢Ժ"

ۡѡ"ζ΢޶"

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Ρȣ²ȣȣű㣬괯

١"񴯣ɱʭڹǽڼ䣬Ŀ"

ڡƱݡ"𴯣ֹѪ⣬ֹʹ"

ۡʳƱݡ"УĿɷ綾ιջ֭ʯҼ壬ζ̡"

ܡʰš"ѪȾﶬӣ磬֭౩ΪĩС䣬þ"

ݡջӱݡ"ëڲϣȥⷢʹȻƣ֭֮кĩǮذ"

ޡϱݡ"ȥʪȣ̵̵ѣΡС㣬Ѫֹ󳦷Ѫȣ䡣"

ߡĿ"űȡ"

ࡶ±ࡷ"ȡ"

ᡶҩԱҪ"Сʳϴ񮡣"

⡶ҽҪ"Ѫʪȣλ㼰֤֮"

÷ڷ1.53Ǯ衢ɢãĩ

ע⡿١ݾ衷"Ѫ飬ںкʳͣйкߣáƢθ뵱顢ػͬá"

ڡͨ"θߣͶҲ"

²ҹ޺ߣǮǮϸǮ֪ĸǮƤǮˮ屭ȡٷ²桷

ʪƦŻűߣǮǮǮɰǮ룬ǮǮǮ׿Ǯ룬¹ƤǮ룬ɢǮˮͨ˺ۡ嵨

ιͣݡʡȣһȡҶظɣΪĩһƽȥƤ⣬ﳴ.ãʲݰ루壩ΪĩͯСڴʢڿϼϡ⼣ȴͭУҩڿϼ壬ľ֮ϡ裬ͩӴԴ貼ʢÿտͯСʮ裬ٷʥݷԲ

ݣϸﱣһˮͯСͬɸ࣬ͩӴÿʮ裬¾£ʱռ÷壩

ͣȡڸɣһȡ֭࣬˲ĩĩһ裬ͩӴÿʳ¶ʮ衣ʥ¼裩

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ŠŧѪֹﵷĩɶСʥݷ

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ηˣﵷ֮ȱ󷽡

ν𣺢ﵷ֮Ҷʯҵȷ֡ɹɣʱΪĩ֮󷽡

١±ࡷ"רȣй֮йȶѪ֮Ѫ֮ҩ湦ɾɳֿʹ޲ҲãᣬԼ油ת֮˹֮ҲȻ˹֮𣬼֮δк֮ҲָаߣöɳΡعƤкݣ֮ڼɳΡعƤֻ֮𣬶йҲ"

ڡԭ"֣һַ紺Ҷ£רк֮ˮ֮ԲԶһʢ΢ƵطӣΪѪ֮ҩΪ"

ۡʡ"רʪȣ㣬ΪʪҪҩΡѪ֮ȣΪŮܴСݡδԣΪ֮"

ע⣬ֵϰʹõģм֣

P֦ǰʹںӱɽա㶫ϡȵأʹڶμ"".

ĵȫݣڽաϺĴȵʹáμ"ĵ"

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ҩơ

ƴQn Ho

ӢSweet Wormwood HerbHerb of Sweet Wormwood

뷲ݡӡӡϸҶ˿ݡƱ

ԡũݾ

1.պ뾰֮ȡʳ֮

2.񱾲ݡͼƣҶףij¡²磬ոɣ˺Ϊ_Ϊƅ_˺Ϊ

3.ͼ񴦴֮Ҷĸߣϸƻ±ӣ״󣬰ˡ¼ӣɡӡҶҩãȼѡ

4.

ԴҩĻԴΪտֲƻȫݡ

ֲﶯArtemisia annua L.

պʹأڲգ飬ɹɡ

ԭ̬ƻ һݱ40-150cmȫ߽ǿӷζֱƣ֦⻬ëҶƽ̵棬ʱлҶʱɫʱΪƺɫëж̱ϽޱҶƬͨΪ״ȫѣƬϸмСĩ״ëɫ浭ɫϸСëĩ״״㣻Ҷխ᣻ϲҶŽϸСΡͷػϸСΣԼ2mmϸ̹Բ׶״ܰС״ȫΪ״ɫΧΪƻΪԻݹԲΡ8-10£10-11¡

ֲ̬ڿҰɽ¡·ߡӰȴ

Դֲֲҹϱء

ࡿѧ ϲůʪ򣬲Σԡӷѿ¶8-25档㣬ɷֳ֣ʣˮõɰΪˡ

༼ Ӻͷ귱ֳӷֳ֦Էֱ3-4½ϸɳϺ󣬰30cm×20cmѨ֡Է2磬10-20cmʱԡѹ࣬ϽӦá귱ֳ3-4ھ꣬ԣÿѨ1-2꣬ѹʵˮԷ

Ҫʱݣʩϡ˷򣬲󣬼ǿһÿи2-3Σʩ˷2-3Ρ

溦 о˲溦桢ϡϻΪ

״״ ԲΣϲ֦30-80cmֱ0.2-0.6cmɫػɫߣӲ۶ϣв衣Ҷɫɫ飬չƽΪ״ѣƬСƬԲλԲΣ汻ë죬ζ΢ࡣ

ɫ̡ҶࡢŨΪѡ

΢ ҶƬۣ±Ƥϸ״򣬴ܱڲ״18-41-80μmϵıƤϸխΡԲΣʽ沼ëëë磬ΪTëϸڱ۳VΣ240-480-816μm3-8ϸɣУϸϴ󣬱ϸ䡣ëԲΣޱԲηϸУɫӷ͡

ѧɷ֡ϲֺࣺأqinghaosu. Artemi-sinin,arteannuinآqinghaosuartemisinin A,arteannuin Aآqinghaosu,artemisinin B,arteannuin Bآ⻯أأqinghaosuhydroartemisinin,de-oxyartemisinin[1-3]آqinghaosu آqing-haosu [4,5]آqinghaosu [5]B칹Cartemisinin C,arteannuin C[5,6]ﻥGarteannuin G[7]ȥBdeoxyisoartemisinin B,epideoxyarteannuin BȥCdeoxyisoartemisinin C,ϩartemisi-tene[5]ᣨqinghao acidartemisic acid,artemisinic acid,arteannuic acid[8]ȥᣨdehydroartemisinic acid[5,9]ᣨepoxyartemisinic acid[10]11R-ᣨ11R-dihydroartemisinic acid[11]methyl artemisinateﴼartemisinol[2]ȥ׻ƻᣨnorannuic acid[12]ȥBdihydroepideoxyarteannun B[13]ƻan-nulide[14]ƣfriedelin3β-ƴfriedelan 3β-ol[15]ȣͪࣻƤپ-6734-ļѣquercetagetin-6734-tetramethylether[1]è۲ݷӣchrysosplenol,chrysosplenol D[4]أartemetin3-è۲ݷӼèݻأ3-methoxychrysosplenolchrysolplenetin353-ǻ-674-ͪ3,5,3-trihydroxy-674-trimethoxyflavone[6]5-ǻ-3674-ļͪ5-hydroxy-3674-tetram-ethoxyflavone[16]ϻĵأcasticin[17]йcirsili-neol53-ǻ-674-ͪpenduletin,5,7,3,4-ǻ-ͪaxillarinȥйcirsiliolأtamarixetinأrhamnetinƤ-3-ѣquercetin-3-methyletherأcirsimaritinأrhamnoci-trinʥأchrysoeriol524-ǻ-675-ͪ524-trihydroxy-624-trihydroxy-675-trimethoxyflavone5783-ǻ-34-ͪ5783-tetrahydroxy-3,4-dimethoxyflavoneƤپ-34-ѣquercetagetin-3,4-dimethylether[18]ɽͷӣkaempferolƤأquercetinľϬأluteolinپأpatuletin Ƥܿ߰quercetin-3-rutinosideľϬ-7-O-߰luteolin-7-O-glyco-sideɽͷ-3-O-߰kaempferol-3-O-glucpferol-3-O-glucosideƤ-3-O߰quercetin-3-O-glucosideپ-3-O-߰patuletin-3-O-glucside6-ɽͷ-3-O-߰6-methoxykaempferol-3-O-glucoside[19]ȣ㶹ࣻݹأscopoletin[1]㶹֣coumarin[3]68--7-ǻ㶹֣6-8-iemethoxy-7-hydroxycoumarin56--7-ǻ㶹56-dimethoxy-7-hydroxycoumarin㶹scoparon[18]ȣӷͣɷ-ԣcamphorβ-ϩβ-caryophelleneͪisoartemisia ketonβ-ϩβ-pinene[1]bornyl acetate18-Ҷأ18-cineoleέcarveolлᣩbenzylisovalerateβ-ϻϩβ-farneseneţͣࣨcopaeneγ-ϩγ-muurolene[8]ϩtricycleneα-ϩα-pineneСͪfenchoneͪartemisa ketonelinaloolԣisolborneolα-ʹα-terpineolԣbor-neol[6]ϩcamphene¹ϩmyrceneϩlimoneneγ-ʹγ-terpineolbornyl isovalerateγ-ϳϩγ-cadineneξ-ϳϩα-ϩα-elemeneβ-ϩγ-ϩ[20]ˮᣨsalicylic acidβ-ϩβ-terpineneα-ϩα-thujene4-ϩ4-terpineol4-ʹ4-terpingyl acetate᷼linlayl acetate[21]ȣᣨpalmitic acid[2]޴stigmasterolβ-޴β-sitosterolʯaurantiamide acetate[16]5-ʮ䱽-3-O-5-nonadecylresorcinol-3-O-methylether[13]ʮŴnonacosanol2-׻ʮ-8-ͪ-23-2-methyltriacosan-8-one-23-olʮʮһhentriacontanyl triaconta-noate229-׻ʮ飨229-dimethyltriacontane[22]ƻ˫annuadiepoxideɽﻷponticae-poxide[23]ԷֱΪ150 000100 000β-߰øβ-glucosidase[24]ȡ

ҩá1.űãȡԲֺϡűűűſűáضűԭϸɱãԺϸںͺϸǰЧؾпԭáĿűЧڻԭˮű͡2.551015mgkg2/죬3죬Ƥ룬ƺűв̶ͬЧ510mgkg2/죬10죬Ƥ뼴ʹűת͸ͪ߿űáغ̼ضСڵIJűԭK173ED50ED90ֱΪ12.6mgkg25.8mgkgؿƶűԭֱɱáءѺ୶ԶűԭIC50ֱΪ75.229.4.43.2nmolLƶԶűԭ6꣨꣩á

2.ãˮҺԱƤ̿Ҹ˾׺˾нǿ־ãԽɫŧ˾˾˸ѾҲһáӷ0.25%ŨʱƤѢ־ã1%ŨʱƤѢɱáпвáƶԽѡ˾󳦸˾ͺ͸˺ѾһĿáеĹ޴Ͷ޴пá

3.ãȡϡ༰ضűűűſűáʾضűԭֱɱá羵۲֤ҪűԭϸĤṹʳɫĤĤĤǺĤԺȾɫӰ졣ʳĤ仯űԭȡӪڽ׶ΣʹűԭѸٷἢγݣų⣬ʹݽʧڲṹ߽ضԼűű୵űЧߡȼԭתʱص㣬űȼʸߡ⣬пѪ漰á

4.ãƱעҺ԰١סȵļԵĽá鷽ƱעҺ˺˺סȵļ⣬бȵζעҺΪŵЧ併صѸٶ־ãڲͰʹעҺ顣Эͬá

5.ãС顢ܰϸת顢õ廨Ѫհ4ָ۲صãضҺԵãϸдٽãܾߵءдٽƢTSϸֳܡעѶBegleѪTBTuTrܰϸáԽСѪIgGƢͼϸСѪIgGע50-100mgkgСǻϸʣ50.2-53.1%ָ1.58-1.91ػܰϸתʣٽϸáɴٽTsϸֳTEϸֹϸؼ֢ʵͷţӶߵá

6.ѪϵͳãĹעؿɼʣļ͹עнѪѹãӰȥصѹӦΪҪϵֱġע20mgkgؿɿͷʧ

7.ãСͱ˯ʱ䡣ضʵЧѶСзá

ԡصļԺǼԶԣСθLD50Ϊ4223mgkgָ47.1ȫϵΪ13.7èȮá󡢴Сȶظҩ;йθע䡢ǻעȣΪ100-1600mgkgҩ3-7죬۲ҩǰһ״̬ʳءѪϵͳܵı仯ԼҪ֯ѧı䡣൱ٴ70ʱδȮèá󡢴ȶѪϵͳ쳣仯Сθ800mgkg·dҩ4ֹȱתøһߡǼԶԹ۲УӦ൱ٴ70ʱδԵ硢ĵ硢ιѪ󡢵׷ࡢʳ쳣ı䣬ҩ21ǵ׵ϸҩǰߣġΡҪʾԲ䡣С̥ʵ飬زӰ޻ΣձԲⶨزձ°á

1ƷҶķĩ1gӼ״50mlݡȡ״ȡҺȥܼ7%ǰļ״Һ10%صļ״Һ111mlˮԡ΢ȣȴ10%Ph3-41%ȻҴҺ1-2Σɫ໯2ɫ ȡƷĩ3gʯѣ60-90棩mlȻ1h˹Һɣ30mlʹܽ⣬20%Ҹȡ3Σÿ10mlϲҸҺɣҴ0.5mlʹܽ⣬ΪʽƷҺȡضƷҴƳÿ1ml1mgҺΪƷҺȡҺ5μlֱͬһ轺Gֲϣ10%ҴҺ105ߵɫƣ365nm¼ӡƷɫУƷɫӦλϣͬɫӫߵ㡣

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2.ѪȡΣôڣˮϡ͵ıѪȣƣѪպĻ΢ȡɡÿ100û200ȡѪ

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Ρȣűȣʪʪ£鷢ȣű

÷ڷ6-15gű20-40g˾ü壻Ʒӱˮ֭衢ɢãĩ󣻻Ʒ󣻻ˮϴ

ע⡿1.ݾ衷Ѫ飬ںкʳͣйкߣáƢθ

2.ͨθߣͶҲ

1.ͼιΪŷ൥֮

2.±ࡷרȣй֮йȶѪ֮Ѫ֮ҩ湦ɾɳֿʹ޲ҲãᣬԼ油ת֮˹֮ҲȻ˹֮𣬼֮δк֮ҲָаߣöɳΡعƤкݣ֮ڼɳΡعƤֻ֮𣬶йҲ

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6.Ʊݡ𴯣ֹѪ⣬ֹʹ

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8.ʰšѪȾﶬӣ磬֭౩ΪĩС䣬þ

9.ջӱݡëڲϣȥⷢʹȻƣ֭֮кĩǮذ

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11.ݸĿűȡ

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13.ҩԱҪСʳϴ񮡣

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