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ҽҩȫ > ҩ > ҩ > S > ʯ

ʯ

2018-07-11 21:23 Ķ:

йҩ䡷ʯ

ҩơʯ

ƴShí Chn Pú

ӢRHIZOMA ACORI TATARINOWII

Ҷɽѡˮݡѡҩ

ԴƷΪǿֲʯAcorus tatarinowii Schott ĸڣȥɳɹɡ

״ƷʱԲΣз֦320cmֱ0.31cmغɫɫֲڣܲȵĻڣڼ䳤0.20.8cmϸƣһԲ״ۣҶ۳ΣҽУеë״ҶࡣӲάԣɫ΢ɫƤ㻷ԣɼάС㼰ɫϸ㣬ζࡢ΢

𡿣1Ʒ棺ƤϸɫеĺɫƤ㣬ɢάҶά ҶάͣάάɻľƤԡάľͼͣάά١άάάΧϸкƷγɾά֯ɢԲϸ

2ȡⶨµĻӷͣʯѣ6090棩Ƴÿ1ml2μlҺΪƷҺȡʯѶҩģͬƳɶҩҺձɫ׷¼ B飬ȡҺ1μlֱͬһ0.5ȼ׻άҺΪϼĹ轺Gϣʯѣ6090棩-82ΪչչȡɣԼ1Сʱƣ365nm¼ӡƷɫУƷɫӦλϣͬɫӫߵ㣻ԵѬߵɫչ¼ӣƷɫУҩɫӦλϣͬɫİߵ㡣

ơȥʣϴ͸кƬɹɡ

ζ࣬¡

龭ġθ

Ρʪθϻ̵ǡƦ

÷39g

ءøﴦù

ժ¼йҩ䡷

ʯѵͼƬ

ҩǵ䡷ʯ

ҩơʯ

ƴShí Chn Pú

񡷣ѡ򣨡ӡҢʱޯҢ£ձݡľѩɴƼ鷽ŽѣϱݡˮݣĿѣҩԱҪţҩֲᡷݣ䷽ҩҶѣĴҩ־ɽѡϪţҩѧʯ򼣨ݲӡвҩֲᡷҰ²ˡˮ򼡢ݣвҩ

ͼ

ԴΪֲʯ

ԭ̬ݱԣֱ58ףƤƺɫҶ״Σ3050ף26ף1ףȶ˽⣬ɫйҶƽУ1030ףΣҶ״720ף24ף뻨ԷвԲ¶޹бϻֱԲΣ512ףֱ24ףԣɫ6Σȶ˶ۣ6Գڻҩɫ˿ΣӷԲΡʣΣԼ2ס67¡8¡

ֲҶҶʯѻ๩ҩãר

ֲɽȪȪˮʯ䡣ֲϸءĴ㽭յȵء

״ﱨԳʱԲΣʱ磬һ㳤320ףֱԼ0.51סһɫɫɫڽܣڼ䳤Լ36ףԳʱεҶۣҽУ·߶Բ״ͻĸۣϸƣڼʱҶά״żжСϸʼӲ۶ϣάԣɫɫɼ״Ƥ㣬άɢڣIJš㣬ζ΢ַʡɫά߼ѡ

ѧɷ֡Ҷоӷͣ0.110.42Ҫɷβ-ϸ63.281.2ϸ8.813.7Ϊʯϩα-Ȅϩʯѵȡᡢлࡣ

ơȥʣϴԽݣ͸Ƭɹɡ

׹ۡ"ɵѺͭϻƺӲƤһأɣ֦ɹɣȥɣá"

ζ΢£

١"¡"

ڡ¼"޶"

ۡҩۡ"ζ޶"

龭ڡΡƢ

١Ŀ""

ڡ׹ҩԽ⡷"ġƢ"

ۡݾ⡷"ξ̫ξ"

Ρϣ̵Ѫɢ磬ȥʪ̵ʣȲ裬նطƣθʹʹ纮ʪԣӸ׶ˡ

ʪθϻ̵ǡƦ

١"纮ʪԣĿף࣬ͨϣĿ"

ڡ¼"Ӹ³θֹС֫ʪԣ죬СűȲ⣬ԡ϶Ŀǡ"

ۡҩۡ"ηʪԣͷ磬£ɱ棬ζ񴯽"

ܡջӱݡ"ƣֹĸʹתοͷ累꣬ɬС㣬ɱس档ʹĩȹ񿣬顣"

ùţ"Ļ"

ޡϱݡ"ξθֹʹ"

ߡĿ"жѪУ̥©ɢӸס֭Ͷꪶ"

ࡶݱҪ"ģȥʪ磬̵θСڶԾ"

ᡶ¡"ֹѪɢӸ"

ݲӡвҩֲᡷ"ηʪԹؽףʹθףȲ裬񲡡"

ϡвҩ"񣬾̵ʻԣظƻʹ"

÷ڷ12Ǯ38Ǯ衢ɢãˮϴĩ

ע⡿꺹ࡢԡѪ

١ݾע"ܴƤΪ֮ʹصơ"

ڡջӱݡ"ǡ⡣档"

ۡҽѧš"߽͡á"

ءøﴦù

ŽѣȥëɣľΪϸĩɷúkɰ£ÿտķǮҽѧ

СȷʧߣѣʯһŽߣǰӡػơΡعƤһΪĩۺ裬״ÿʳʮ裬Է¡⡢Ѫǡҡ÷ռ÷裩

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κԶ־˲θķ֣߶һζɸذǧ𷽡ɢ

಻㣬dz˲֣ϲĺ磬ĺѣѡԶ־ߡ˲θζĩ֮裬Ӵ裬ǧ𷽡־С裩

ʳѪࣺ֮ʯѰﱣèȥ㣬ζͬɫȥèãôֲʢǣȥèмˣȴΪϸĩ裩ͩӴÿʮ裬¾ƻ¡Ч

ηԣʹѣﱣػƣȥУ轸ȥģͷѣȥƤ꣬ﱣ½ȥУбƬζһޣɣɾУԾƾΪȣɣɸΪϸɢÿ¾ƵһǮذٷʥ¼ɢ

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ʹʯѸǮĥˮٷҩ

ڶײߣʯһʲݡȳǮ.Ϊĩݻԡ

λкֹѣбƤȥףһʲݣˣζΪĩÿǮذˮһյʮУ¶ٷʥ¼

γ״£ʯѡƹֽȷ֡ΪĩÿǮѽƵһ

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ʪʯѡߴӵȷ֣ΪĩղΡüɷ

עƷ⣬бֲϸҶѣǮѣĸͬҩһƷѡ

Ŵ׳"һŽ"ʱƷоŽ֮Ŀǰһëݢֲﰢ̩ĸŽѡμ"Ž"

ժ¼ҩǵ䡷


лݡʯ

ҩơʯ

ƴShí Chn Pú

ӢGrassleaf Sweelflag Rhizome Drug Sweetflag Rhizome, Rhizome of Grassleaf Sweelflag

ѡݡҢʱޯҢ¡ľѩˮݡѡšݡҶѡɽѡϪšʯ򼡢Ұ²ˡˮ򼡢

1.ͼѣ񴦴֮ݡ߼ѡҶһҶм״罣޻ʵ¡ʮ²ɸɡ֮нڣ״޴һĸܣһŽ߼ѣһʮߡ֮ɷʵ֮ɫ΢֮࣬ҡ˶ֲڸɳʯУ֮׻ĸzhouʹߣȡһ紷飬ͬǼ֮

ԴҩĻԴΪǿֲʯѵĸ

ֲﶯAcorus tatarinowii Schott

պʹأԺ3-4ջ紺ĩڳȥҶƬϴɹɣײȥë뼴ɡ

ԭ̬ʯѣݱԣ㣬5-8mmƤƺɫڼ䳤3-5mmϣ߶ϲ֦ܣֲɴ״֦ά״޴ҶҶƬΣ20-30-50cmۣвƽչ7-13mmȶ˽ĤʣҶʿɴ5mmӼҶƬвɫƽ¡𡣻4-15cmΡҶ״13-25cmΪ뻨򳤵2-5ϡȳ뻨Բ״2.5-8.5cm4-7mmϲ⣬ֱ䡣ɫ볤7-8cmֿɴ1cm׹ɫʱɫưɫ2-6¡

ֲ̬ں20-2600mʪػϪʯϡ

Դֲڻƺϸء

ࡿѧԣϲʪ٣ʪͺɸɺʪػˮɰֳΪˡ

༼øֳڳѡҶƬС֣30cm×15cmѨԣÿѨ2-3꣬Ժѹ

ԺעγӲݣͽˮмɸɺ׷ʩ˷2ΡԵΪʵ׼طʡÿջͶº󣬶ԱһСֲ꣬Լӹ2-3ֿջ

溦Σ溦еȣΪҶƬ90%аٳ1000ҺΡ

״״𣬸ʱԲΣз֦3-20cmֱ0.3-1cmغɫغɫһɫֲڣ໷ڣڼ䳤2-8mmϲԳʱεҶۣҽУ²Բ״ۣڲʱë״ҶӲ࣬۶άԣɫ΢ɫƤ㻷ԣɼάС㼰ɫ͵㡣㣬ζࡢ΢֡ɫסŨΪѡ

΢𣬸棻Ƥϸ෽ΣеĺɫƤ㣬ɢάҶάҶάΪͣάƤ㿭ϴԡɢжάΪľͣƤ㻷нܣάΪľͣƤ㻷нܣάʱɼάάΧ1ȦϸоƷ֯ɢԲϸϸ

ѧɷ֡ʯѸӷͣα-β-γ-ϸ(asarone)ŷϸ(euasarone)˳ʽ׻춡ͷ(cismethylisoeugenol)֬(elemicin)ϸȩ(asarylaldehde)δ-ϻϩ(δ-cadinene)(thymol)ⶹͶ(myristic acid)

ǮѸӷͣУα-β-ϸԣŷϸԣ˳ʽ-4-ϡ޼«(TCMLIBans-4-propenyl veraTCMLIBole)Ƿʽ-׻춡ͷ(TCMLIBans-methylisoeugenol)4-ϩ޼«(4-allylveraTCMLIBole)Ǽ׻ͷ(methyleugenol)֬أϸȩϸ(bisasaricin)α-β-ϳϻϩ(cubebene)ϩ(caryophyllene)β-ܿϩ(β-gurjunene)ϩ(eremophilene)Ȼ崼(nerolidol)´(guaiol)Ǯϩͪ(gramenone)12--4-(E-3-׻)[1,2-dimethoxy-4-(E-3-methyloxiranyl)benzene]124--5-(E-3-׻)[124-TCMLIBimethoxy-5-(E-3-methyloxiranyl)benzene]ȡ

ҩá1.ϵͳã1.1.ãϸֵܲضԿأTCMLIBemorineĴʵ԰ͽɭۺļòƷѻӷͶԵͻϥƣԶͻã˵俹߶ͨƣϵԵļɳڼòλڼƤ¡

1.2.羪ãȡ18-22gС70ֻ۽ԿɣΪ7飬ÿ10ֱֻǻעα-ϸ90mg115mg130mg140mg150mgkg50mgkg0.6ml20gƣ30Ӻ׷̼α-ϸѾжԿ羪ʷãڱӢơбα-ϸѶԵݿ˾ԶԿá

1.3.ԿĵԾʵãȡ18-22gС30ֻ۽ԿɣΪ3飬ÿ10ֱֻǻע140mgkg α-ϸѣ50mgkgƣ0.6ml20gơ30Ӻٸǻע38mgkgĵԳԾΪָꡣСϸԶԿĵԾáбα-ϸѶĵԶԿáʵα-ϸ140mgkgʿСǿֱԾʡ140mg/kgǻעҲܶԿòעľʡ2030g/kgˮ30g/kgȥˮСĵʡ

1.4.ʯƵЭͬãСǻעҩԷʧָΪָ꣬۲ҩЭͬáʯ12.426gkg15 LD506.213g/kg110 LD501ֻС˯ߡ40mgkg16ֻС10ֻ˯ߣֱעʯ20Ӻע40mgkgƣܼǿãP<0.01

1.5.ʯѶСӰ죺ǻעα-ϸ2448mgkgС󼰴ԷԼ٣бϸ15mg/kgСԷرӰ졣עα-ϸ15mg/kgйΪĺδ۲쵽ԵİáһСͣʳ12Сʱʵ顣ǻע30ӷڣ¼10ӻˮȽϣʯСP<0.01ҩ12.426mgkg鲢ܷdzŵƱ˶˷ܡбǻעʯˮ1510g/kgСԷ½ûӷ͵1/61/3ҲԼСԷܼƼ˷ãɽСĹΪ

1.6.ϸѶ¼ͱƵЭͬãС90ֳֻ9飬ǻעҩ20ӣٸǻעͱ15mgkg۲ÿ鷭ʧα-ϸѼ2448mgkgʱͱһЭͬãбϸ15mg/kgӳͱ˯ʱ47%ʯѻӷ0.05ml/kgСǻע䣬¼ͱЭͬáˮȥˮ´߼ͱƾЭͬãӷ͵1/61/3ӳͱƵʱ䡣

1.7.ʯѶԾʯСŤᷴӦӰ죺С60ֻΪ6飬ֱƤע12.246g/kg6.213g/kgԵˮ10mgkg20עʯҺ0.2ml/ֻ۲ÿֻС10ڳŤᷴӦĴtͳѧڱʵüԶԿŤᷴӦP<0.01ʯ0.1213gkgʾԿŤᷴӦP<0.05ʯˮ崼Һ6.213g/kgǻע䣬СŤ巨Ȱ巨鶼ʹá

1.8.Сǻעα-ϸ24mgkgԱĶޱá

1.9.򾲣ˮ4g/kg,СáˮѵĻӷ10-100mg/kgС󡢴èãԷͼĽԣ̼ķӦΪα-ϸ3mg/kgǻע䣬Եãҳ4СʱϣǿȺʱ3mg/kgȱƣʹѽĴرƻ⣬ܶԿ»üƼmescalineԴĹȻ»ΪƤעα-ϸ1mg/kg1СʱֳԵãȫΪΧȤ̽½Ϊ5mg/kgʱøԣʱɳ90Сʱ,ʹܵʱԱΪĮ޵⡣50mg/kgþעɲƽ7.2ӵã100mg/kgʱ15.5Ӳ֫Ӳ

2.ϵͳӰ죺ڷܴٽҺķڼֹθ쳣ͣгڻƽεáѻӷ1500000,سܼԳܵ˷ãŨȼӴøţα-ϸ125000119000125000β-ϸ1300011200011200016000ֱ10-4mol/L5-ɫ鰷ܵá⣬ѻӷͻжݵĽѪѹüƵøá

3.СѧϰĴٽã3.1.СѧϰӰ죺NIHСԣ20±2g25±2g,ԹʳӦԹ׷ƣС130×85×13cmɲ͸ϰƳɣϸ͸лԱ۲죬ԹյʳĵȣСÿ1ֻԹѰȡʳȷ;յʱ䱥ʳ2Թ֮ʳСԹڵյʱʹʱԽ̣˵СѧϰͼԽá20ڻ󣨴3ΣյΪѧԹ

3.1.1.СѧϰͼӰ죺ȡС55ֻ3ĸԹʳӦѵѡȡԽһ33ֳֻ3飬ÿ11ֻ飬ÿθͬˮҩÿֱθʯҩҺ0.10.2g10g,൱LD50154127ͬʱѵС󣬳6죬ʯСԹȡʳʱ䣬ٴ456ԹʱʹȽϾԲP<0.014ȽP<0.0556ȽԲ졣ʯܴٽСѧϰͼá

3.1.2.С乮Ӱ죺ȡС55ֻ10츴ԹʳӦѵѡȡѧԹȡʳ20ڴ󲻳3εյ㣩ʱһ33ֳֻ3飬ÿ11ֻ飬ÿֱθͬˮҩ飬ÿֱθʯ0.10.2g10gҩ10죬ڼֹͣѵ11죬۲С10ǰѧԹȷ;ļ乮̶̳ȡС߹ʱʹҩȽŲ졣ʯѶСļ乮޴ٽá

3.2.ԻѧҩƷСϰĸã3.2.1.ݹмɼϰãȡС55ֳֻ5飬ÿ11ֻAΪ,BΪݹмģ,CDֱΪʯ0.10.2g10g,eΪԸ飨100mgkg7졣δθҩ4СʱA鸹ǻעͬˮ,BEǻע䶫ݹ1mgkg15ӺԶ̨ѵ24Сʱɼʯ0.10.2g10gʹСʱż٣붫ݹмģȽP<0.01֮Ų졣顢Ը붫ݹмģȽP<0.01ݹмСϰʯѶԴ˾Եĸá

3.2.2.ɼ乮̲ãȡС55ֳֻ5飬ҩ7졣ĩθҩ4Сʱ̨ѵѵƤע120mg/kg24СʱɼʯѿʹСʱż٣ȽP<0.01޲죻ȽP<0.01ʯѶɵС乮̲ŵĸá

3.2.3.ҴСȱʧãС55ֻ飬ҩ7졣ĩθҩ4Сʱ̨ѵ24Сʱڲǰ30ӹθ40%Ҵ0.1ml10gʯѿʹСʱĴż١СȱʧԸá൨ϵͳѧϰеĹϵԳմAlzheimers disease뵨񾭴ȱйҩݹмԽ֢ļϰʯŶԿݹмļϰƲҩܾеЧӦʯѶɵļ乮̲ԵĸáʯܱȱԹܼˣȱɵļ乮ϰҴɵȥܺ͵ϵͳԼԲݵ𺦣ݶﳤҴʹƤʡȥܡ񾭲ȥã־õؼϰҲϱҴж5-ɫˮƽ½ΪʵIJͬ׶θҴɵ¼ϰʯѶҴļȱʧиã˵ʯѿܸƴȥܣ񾭹ܺ͵5-ɫˮƽ

4.ãα-ϸ0.5mg/kg3mg/kgǻע䣬ֱܷ𽵵С1.83.5棬ܷתҰΪ£ƽ1.3档бϸ޽ã಻ܶԿҰá

5.⾷ã5.1.ܵĽ⾷ãα-ϸѶԿ¾Ach鰷Histɫ5-HTнŨΪ10μg/mlα-ϸѶԿ鰷ɫ백ƣĶԿԶڰα-ϸȫ¾õŨȣԿΪ40μg/mlԿ鰷Ϊ80μg/mlԿɫΪ53μg/mlЧڰβ-ϸѵϩ1-ϩ-24,5-Ƶãα-ϸ

5.2.سĽ⾷ãʵ󳦹ƽЧα-ϸΪţԿ鰷Ϊ20μg/ml,ԿɫЧŨΪ10μg/mlΪӷ͡Ľ⾷

6.ãʯѻӷ0.0420.085ml/kgθ7죬Сá0.062ml/kgǻע,0.085ml/kgθ,9,С-180áʯ20%ȫɱСˮϸ

7.ãСļжҪ֢״Ϊ鴤̼շͼӾ鴤ǿֱԾʣ˵жҪ˷ܼ衣ijЩԹã飬ŨȽҺԳ°ƤáѡҶۻƺѬ12ļʹ׳Ժ70%

ԡ1.ǻעѻӷ͵LD50Ϊ221mg/kgҩȳԾʣǿֱԾʡʯѻӷ͹θСLD50Ϊ4.706ml/kgǻעLD50Ϊ0.23±0.02ml/kgӷСƤעLD50Ϊ0.157mlkgжΪЪԳ鴤Сʱ10СʱǿֱԾʣ˵ʯѻӷжҪ˷ܼ衣

2.α-ϸѰϷⶨСǻעLD50Ϊ338.5±9mgkgҩּɳۣƵʼ֢״16-24Сʱ24СʱڲͲƽ巨һ֤ʵα-ϸΪձʣ˺ɳϾͻTA100,TA98ͻá

3.ʯˮСǻעLD50Ϊ53gkg38g/kgʱж֢״ΪѣԳ鴤

𡿱ɫףȡƷַ20gûӷȡˮûӷȡˮˮѣûӷѹα-ϸѼ׻ΪƷֱڹ轺G-0.8%CMC-Naϵʯ-(85:15)չ(254nm)¹۲졣Α -ϸΪɫ׻Ϊɫ

ơ1.ȥʣϴԽݣ͸Ƭɹɡ߲ɵѺͭϻƺӲƤһأɣ֦̳ɹɣȥɣá

ζζࣻ΢

龭ģΣƢ

Ρ̵ϣʪԣֹʹȲ裻̵ʣ丹ʹʪʹˣӸҽѢ

÷ڷ3-6gƷӱ衢ɢãˮϴĩ

ע⡿ࡢ

1.Ŀ£֮ĸҲο༱֮ӡ

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