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ҽҩȫ > ҩ > ҩ > T > ɽѩ

ɽѩ

2017-07-06 23:04 Ķ:

ҩơɽѩ

ƴTin Shn Xu Lián Hu

ѩѩɻѩ

ԴҩĻԴΪտֲѩĴȫꡣ

ֲﶯSaussurea inuolucrata Kar. Et Kir.

պʹأ6-7¿ʱգȥɳɡ

ԭ̬ѩ ݱ15-35cm׳жά״غɫҶ׳ֱ׳ֱ2-3cmëҶܼҶҶƬΪΡԲλ״ԲΣ14cm2-3.5cmȶ˶ۻԼ⣬ӣԵݣԵмݣëݼͷ״ëϲ13-17ųɶĤʰҶ5-7cm˽⣬Եݣ2ͷ״򣬶10-20ھܼ״޹ܰΣܰƬ3-4㣬Σȶ˼⣬Եȫڣ賤ëɫԼ14mmȫΪ״ɫݹԲΣԼ5mmߣ2ẹ̈ڲ㳤ë۰ɫë״ڲë״6-7¡

ֲ̬ں3000mϸɽҷ졢ʯɳʺ̲С

ԴֲֲڸࡢຣȵأԼ½ɽɽĸɽ

״״ ҩĶ顣غɫ,ľʻ,ⲿ˨Ƥ״,۶ֲ,ڲưɫ΢,΢㡣ֶ,дڶҶά׳,,пաҶ,вл,ܼҶչƽʳλ,ԵоݺԵë,ɫ,ʡҶλ,ưɫ,Ĥʡͷ״10-30ܼ״,̣ܰʰΣܰƬ3-4,,ʺɫ,汻ڶë,ڲػɫưɫ,ȶ˱ëȫΪ״,Ϻ,ҩɫ,ͷ2,Գݹ,,Ұɫζ΢,

΢𣺰Ҷ棺ϱƤϸԲλ೤,,Ժ,±Ƥ,ɼëͷëIJл,Ҷϸ2-6,ϸ״,͹,ϱ԰,ά˫,3-5

ĩɫ

٣ײʽ,Լ42μm,Լ32μmڣëΪϸ,ϸζ̡ۣëͷΪϸ

ܣԲ,ֱԼ45μm,д״ͻ,ȷ3ݣͷͻƬë״״ͻ

ޣлƺ,ֱ15-40μmߣά,ڱ,ǻ

࣮ëƬڶ,״Ʒë

ѧɷ֡1ȫݺҩԵĶ,ƽ16000,ϵ(glucose),( arabinose),(rhamnose)Ͱ(galactose)Ħ 12.ll.33.9ɡɷ֣ľ(guaianolide),ľ-β-߰(guaianolide-β-glucoside),ѩ(xuelian-lactone),ѩ(involucratolactone),ѩ-8-β-D-߰(involucratolactone-8-β-D-glucoside),ȥľ(dehydrocostuslactone),ȥľ(dihydrodehy-drocostuslactone),8α-ǻ-11βH-11,13-ȥľ( 8α-hydroxy-llβH-11,13-dihydrodehydrocostuslactone),3α-ǻ-11βH-11,13-ȥľ-8-O-β-D-߰(3α-hydroxy-11βH-11,13-dihydrodehydrocostuslactone-8-O-β-D-glucoside),3α,8α-ǻ-11βH-11,13-ȥľ (3α,8α-dihydroxy-llβH-11,13-ihydrodehydrocostuslactone),llβH-11,13-ȥľһ8-O-β-D-߰(11βH-11,13-dihydrodehydrocostu-slactone-8-O-β-D-glucoside),8α-ȥľ(8α-propionyloxy-dehydrocostuslactone),󼻿(cynaropicrin),11α,13-󼻿(1lα,13-dihydrocynaropicrin),1lα,13-ȥ󼻿-(4-ǻͶ)[1lα,13-dihydrodesacylcynaropi-crin(4-hydroxytiglate)],٤ʸ(janerin),19-ȥ٤ʸ(19-deoxyjanerin),ȥ٤ʸ(desacyljanerin),٤ʸ-(4-ǻͶ)[janerin-(4-hydroxytiglate)],11α,13-٤ʸ(1lα,13-dihydrojanerin),11α,13-ȥ٤ʸ-(4-ǻͶ)[11α,13-dihydrode-sacylianerin-(4-hydroxytiglate),11α,13-ȥ󼻿(11α,13-dihydrodesacylcynaropi crin)

2ֺͪɷ֣Ƥ-3-O-α-L-߰(quercetin-3-O-α-L-rhamnoside),Ƥ(quercetin),4′,5,7-ǻ-3′,6-ͪ(jaceosidin),ë(hispidulin),ܿ߰(rutin)

3ѩ(involucratine),Լţ߰Ԫ(arctigenin),޺֬(matairecinol),ʯ߰Ԫ(trachelogenin),ľ(costie acid),߰(syringin),-β-D-ૹ߰(butyl-β-D-fructopyranoside)ȡ

4ӷ,У1-ʮ̼ϩ(1-pentadecene),4,4,7α-׻-5,6,7,7α-ⱽ߻-2-ͪ(4,4,7α-trimethyl-5,6,7,7α-tetrahydrobenzofuran-2-one),¹(ethyl laurate),ʮ(n-hexadecane),2,6-(嶡)[2,6-di(tert-butyl)benzoquinone],ʮ̼ϩ(heptadeca-triene],ʮ(ethy tridecanoate),1,6-׻-4-(1,6-dimethyl-4-isopropylnaphthalene),1-ʮ̼ϩ(1-hep-tadecene),ʮ(n-heptadecane),ⶹޢ(ethylmyris-tate),ʮ(n-octadecane),6,10,14-׻-2-ʮͪ(6,10,14-trimethyl-2-pentadecanone),ʮ(ethylpentade-canoate),1-ʮ̼ϩ(l-heptadecene),ʮ(n-nonadecane),(methyl palmitate),ȥľϩ(dihydrode-hydrocostunolide),ڱ(dibutyl phthalate),(ethylpalmitate),ʮ(n-eicosane)ȳɷ֡

ҩá1.ã[3H]TdR 뷨,12243648Сʱ,۲쵽ɽѩͪ໯4′,5,7-ǻ3′,6-ͪʹë,Ƹˮ͸ΰS180ϸDNAϳɡ߶Ըˮ͸ΰϸDNAϳɵID50Ϊ70.8μg/ml 116μg/ml,ڶS180ơ4′,5,7-ǻ-3′,6-ͪ԰ϸDNAϳɵƻƿDNAģ͡ɽѩL7712ϸDNAϳɵID50Ϊ5l.7g/ml80g/mlDNARNA͵ʶŵá24Сʱõʾ80%ϡRNAϳɵƷʽģ͡

2.Ѫϵͳã21ѩܼѩҴɽͼƤѪܵͨ͸,ýǿ

22ѩܼʹöѪ,ҴѪܳá

23ѩܼܻͪܽúȮѪѹ

24ѩܼ,ʹȱС,ʼ,ͣ

25ѩܼԼĵͼΪʼT͹,ɳ10ӡ

3.ƽãѩܼ鰷ëܿƽ,ŵĽ⾷ãѩֵܼܲضԿ鰷ܻá

4.ã5%ѩܼ2ml/kgѩҴȡ10gҩ/kgǻעԵҺĴ׹ؽڼ֢ŵĶԿ,ܼǿ,ǿˮơ,ܼнͼѪͨ͸Եá

5.ɻͿƣãɽѩ״ȡ,õɫøöɻİŨΪ22.Oμg/ml,95%Ϊ19.9-24.lμg/mlСȽͱᷴӦIJ,IC50Ϊ2.3mg/gʸ,95%ĿΪ2.05-2.55mg/gʸءǸǻע25mg/kg5ɽС34.4%,ǻעͬ6ʹСӾʱӳ1.69

ζζࣻȣж

ΡʤʪѪͨϥʪʹŮ¾վ丹ʹ

÷ڷ0.6-1.5gơ

ע⡿иÿж

1.½вҩ"иɷ"2.ȫвҩࡷ"иɷƷж,ɳִ졣"3.ɽҽ־1986,524"ʧѪѹ½֫巢顢Ż¡ʾѩ񾭡ѪܵĶӰ졣"

ѩƷֽ϶,ڸɽѩ֮,ɻҪֲ½ɽȸɽ,ʳɽѩ½ѩ

1.ʫ"ѩ,ǧ겻Ԫѩ֮,,߿ȡ,ɫ֮ȴ"2.ǡ"ѩѩ,һ,ɫ̡,˳书ͬé,֪ͬʯëҲ"3.¼"ѩ,ɽѩ,״֮,˫,߲,С,Ȼ,಻ͬ,ȥһ,һ,һ,޲ߡ"4.Ŀʰš"ѩɻ,𴨵ȴ֮,ѩIJɢ,ѩв,ɻ,,ͤͤѩɰ紺,ʷ̫ش׼֮,Ϻɻϸ,걡,Ĵ,Ʊͷƽɫ΢,˴˷֮ΪҪҩ"

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