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2018-11-07 10:53 Ķ:

йҩ䡷

ҩơ

ƴWú Zh Yú

ӢFRUCTUS EVODIAE

ǡӡӡ⽷

ԴƷΪֲܿEvodia rutaecarpaJuss.Benth.ʯEvodia rutaecarpaJuss.Benth. var. officinalis DodeHuang ëEvodia rutaecarpa Juss.Benth. var. bodinieri DodeHuangĸʵ811¹ʵδʱ¹֦ɹɻ¸ȥ֦Ҷʡ

״ƷλԳ״Σֱ25mm氵ɫɫֲڣж״ͻµ͵㡣״϶лɫëĹӲ࣬ɼӷ5ңÿеɫ1Ũζࡣ

𡿣1Ʒĩɫë 26 ϸ 140350 μmԣеİǻںػɫغɫëͷ 714ϸԲΣɫں 25 ϸƴؾ϶ֱ࣬1025μmżзʯϸԲλ򳤷Σֱ3570μmǻƬʱɼɫ

2ȡƷĩ0.5gҺ1→10010mlҡӣ˹ȡҺ2ml ӵ⻯Һ 1ΣҡɻưɫȡҺ 1mlԶװȩҺ 2mlˮԡϼȣҺӽ紦ɺɫ

ⶨոЧҺɫ׷¼ Dⶨ

ɫϵͳ ʮϹ轺Ϊ-ˮ-߻-ᣨ514810.1ΪࣻⲨΪ225nm۰ǰӦ7000

ƷҺƱ ܳȡǰǴμƷӼ״ֱƳÿ1ml0.1mgҺá

ƷҺƱ ȡƷĩɸԼ0.13gܳƶ״80ml,Ȼ50ӣ䣬˹Һռ״ת10mlƿУӼ״̶ȣҡȣá

ⶨ ֱȡֶƷҺ빩ƷҺ5μlעҺɫǣⶨá

ƷǰC19H17N3OǴμC18H13N3O0.20

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ȡʲݵ飬ˮȥ뾻ǣ󣬳΢ɣȡɹɡÿ100kgǣøʲ6kg

ζ࣬ȣС

龭ΡƢθ

ΡɢֹʹֹŻֹкͷʹ޸ʹʪиʹ丹ʹŻᣬйкοڴѪѹ

÷1.54.5g

ءﴦ

ժ¼йҩ䡷

ͼƬ
ͼƬ

ҩǵ䡷

ҩơ

ƴWú Zh Yú

ǣľ㷽м־

ԴΪֲܿδʵ810£ʵʲɫƤδʱաժɹɣȥʡ꣬΢𿻸ɡ

Ʒ⣬ֲͬʯëȵδʵͬʹá

ԭ̬ǣӡӡҩӡ

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ֲĸǸҶҶ๩ҩãר

ֲҰɽء·Ի¡ֲڳ򼰻һȵءݡϡϡ㽭Ĵȵء

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ʯʵǼǴμǻǼк͵ͪݳʯءӷ͡ɫ߰廯

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з÷ʿֵƳ10ֲ࣬Ϳÿ12Ρҩǰˮϴ12һ46μ

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ǵ飬ɸȡϸĩô׵ɺ״Ϳɴϣ˫ӿȪѨ24Сʱȡ¡10.52Ǯ1523Ǯ61534Ǯ1545Ǯ256247һҩ1μЧ

עǵĹЧСɢٴʵϼñƷͳ没ٴʵѧΪԵֹʹֹŻá

ժ¼ҩǵ䡷


лݡ

ҩơ

ƴWú Zh Yú

ӢMedcinal Evodia Fruit, Fruit of Medicinal Evodia

ʳǡӡӡҩӡӡ

ԡũݾ

ԴҩĻԴΪֲܿǡʯëδĹʵ

ֲﶯ1.Evodia rutaecarpa Juss.Benth.2.Evodia rutaecarpa Juss.Benth.var.officinalis DodeHuang3.Evodia rutaecarpa Juss.Benth.var.bodinieri DodeHuang

պʹأԺ3꣬Ʒ7ѮƷ8ѮʵʲɫƤδʱգ¶ˮδǰժ룬ժϹ֦ɹɣ꣬ʹ䣬ᄏ죬΢𿹸ɡ

ԭ̬1.ƤҺɫ֦ϺɫϸСԲεƤף׼Ҷἰɫë״ҶҶ20-40cmҶ4-8cmСҶ2-5mmСҶ5-9ԲΣ5.5-15cm3-7cmȶɶ̼⣬ШШλԲΣȫԵвԵĶ۾ݣԣƺɫëȶ࣬Ե͵㣬ֽʻֽʡ꣬ɡԲ׶򣬶׳ܱƺɫëСҶƬ״СƬ2öƬ5ΣԼ1-2mmë5ɫԲΣ4-6mmۻ5ڼСĻϣҩţԲΣ˿ֶ̣ë˻ӷȶ4-5ѣƻĻۻ˻Ƭ״ӷλԲΣƤ5ɱԲΣдִٵ㣬ֶ̣ͷȶ4-5ǮѡʵΣʱѿ5꣬uȋ״Ϻɫдִٵ㣬ÿֹ1ɫй󡣻6-8£9-10¡

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3. ë ơС֦ɫ˿ʵ賤ëҶᱻëСҶ5-11Ҷα仯ϴ󣬳ԲΡΡ״ΣϱԱëϱëٵС7-8£9-10¡

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2.ɽ²ݴС

3.ڴ·ԡɽ²ݴС

Դֲ1.ֲࡢա㽭̨塢ϡ㶫Ĵݡϡ

2.ֲ㽭ϡĴݡ

3.ֲڽϡ㶫ݡ

ࡿѧ ϲůʪ򣬲ͺ䡢ѡ㡢ɷ֡ˮõɰϺ͸ֳΪˣݻˮزࡣ

༼ ӡꡢǤ己ֳӷֳȡƽ׳ֲ꣬ʵգɣмɹʹʧȥѿ3Ѯ-4Ѯ巨о15-20cm3-5cmӾȲ룬ϸDzһ㣬ˮʪֳٶá귱ֳ12ѮĸԾ0.6mıٿ¶ϴֵIJÿ7cmҿһ˿ڣٸʩʡ˿ڴ磬糤󣬼ĸ롣Ǥ己ֳ֦巨11-12»1-2ֲѿǰȡ1-2׳֦Ϊ룬20-25cm3-4ѿ˼б棬Ǥ紲¶5-10cmһ㣬ע⽽ˮǤԼ1-2230cmԡ巨ѡ4-6꣬2Ѯǰѡϴ׳IJس15-18cmС룬15cm×15cmѨÿѨбһΣˮڶͿԣֲʱ3-4»11-12£ࣨ1.5-2m ×1.5-2mѨѨ60cm45cmʩ븯Ƿʣպཬ֣ѹʵˮ

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΢ ʵ棺ԲΣΪ5ҡƤƤϸ1УԲΣ룬ຬƤ߰ᾧɼ׺ëëİ̺ۡйƤϺɢάͶңֱ120-180μmϸƴؾڹƤܣؾֱ12-16μmڹƤ4-5бϸΣУйƤϸСʵÿ1ӣΣƤʯϸդ״УڽϺƤȫΪ֯

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ѧɷ֡Ӻ˳ʽ-58-ʮ̼ϩᣨcis-58-tetradecadienic acidʵĻӷкϩevodeneevodolʿأlimoninʵкǼevodiamineǴμrutaecarpineǿƷevo-carpineǻǼhydroxyevodiaminewuchuyineϩocimeneͪevodioneǾevoginǿأrutaevin7-ȻǼ7-car-boxyevodiamineǴμdihydrorutaecarpine14-Ǵμ14-formyl rutaecarpine1-׻-2-ɻ-41H-ŵͪ[1-methyl-2-nonyl-41H-quinolone]NN-׻-5-ɫNN-dimethyl-5-methoxytryptamineN-׻ڰ᰷N-methylanthranoylamide֣synephrineȥǼ dehydroevodiamineevodiamideȥ׻[N-2-methylaminobenzoyltryptamine]6a--5-ʿأ6a-acetoxy-5-epi-limonin6β--5-ʿأ6β-acetoxy-5-ePi-limoninưͪobacunone޵÷jangomolideǿrutaevine acetateAgraucin A12a-ǻʿأ12a-hydroxylimonin12a-ǻ12a-hydroxyevodol1-׻-2[Z-6-ʮһ̼ϩ]-41H-ŵͪ1-methyl-2[Z-6-undecenyl]-41H-quinolone1-׻-2-[Z-10-ʮ̼ϩ]-41H-ŵͪ1-methyl-2-[Z-10-pentadecenyl]41H-quinolone1-׻-2-[Z-6-ʮ̼ϩ]41H-ŵͪ1-methyl-2-[Z-6-pentadecenyl]41H-quinolone1-׻-2-[6Z9Z-69-ʮ̼ϩ]-41Hһŵͪ1-methyl-2-[6Z9Z-69-pentadecadienyl]41Hquinolone1-׻-2-[4Z 7Z47-ʮ̼ϩ]-41H-ŵͪ1-methyl-2-[4Z7Z-47-tridecadienyl]-41H-quinoloneǹgoshuyuamide 񣩣ǹgoshuyuamide 򣩡⣬ʵл춬ᣨaspartic acidɫᣨtryptophanհᣨthreonine˿ᣨserineװᣨcystineʮְᡣ

ʯʵevodinֳʿأlimoninǼǴμǻǼʯأShih-Hu AǿƷǿƷdihydroevocarpine1-׻-2-ʮһ-41H-ŵͪ[1-methyl-2-undecyl-41H-quinolone]1׻-2-[Z-6-ʮһϩ]-41H-ŵͪ1-methyl-2-[Z-6-undecenyl]-41H-quinolone

ҩá1.Ѫϵͳã

1.1.ǿã

1.1.1.8ֻģͬһؽ衣ʾǿüСʱ䳤ؼӿʵãʿļ֮ס

1.1.2.3ֻ1.75±0.09kgԱ𲻾С󣬿أļмסļⲿӻе绻ԶǼ¼ߡԵ0.3gkg۲30ӣȻע2%ͱļԼٸ۲30ӡɼǿҩ30δָҩǰˮƽ

1.2.ѹã

1.2.1.3ֻԲʽѪѹʾɶѪѹҹɾ0.2gkgҩǰѪѹΪ13.29±5.71kPaX±SDͬҩѪѹ߷Ϊ24.36±5.60ֵΪ10.79±1.24P0.01ͷΪ11.07±5.41ֵΪ2.20±0.73P0.05ѹά368±635ָ½ά565±95s

1.2.2.9ֻˮѹ۲ҹɾ1.04gkgעҺѪѹӰ죬ͬʱĵͼʡ3ֻ󣬹۲0.04mgkgضѪѹӰ죬ѹãҩǰԱȲ켫ţP0.001ȡ6ֻΪ顣һԤȸĵð1.8mgkgһԤȸ3.0mgkg5ӺٸעҺ1.04gkgѪѹǰȡѹܱĵðϡϽѹѸ٣ѹʻαβʵǻŵα˷úͽβ-˷ãΪαβ˷ܼк˲ϴЩʵ鲢ȫ˵ǶѪܵҩá

1.3.ԼĤ΢ѭӰ졣

11ֻλ̶ڱ̨ϣ΢ѭ΢Ŵ80Դ¹۲Ĥ΢ѭԵעˮ0.3mlkg5ӺעעҺ0.3gkg۲첢ȡҩǰ΢ھëϸѪ¼΢Ѫ̬ϸۼĶ̬仯ҩ΢ѪٶѸ죻΢Ѫ̬ƣ

2.ϵͳã

2.1.θã

2.1.1.ˮӦӰ죺ȡС50ֻ21.2±1.2gΪ5飬ʳ1ҹֱθˮɺˮװƵӦڣ20-23ˮУʹˮλﵽС󾱲8СʱСȡθ״𺦣ѪΪָڷ2gkg50%״ȡпˮӦãʴ66.6%

2.1.2.ʹҴӰ:ȡС50ֻ23.4±1.9gΪ5飬ʳ24Сʱֱθˮ߻ͪˮ30Ӻǻעʹ10mgkglСʱٹθ50%Ҵ0.2mlֻٹlСʱȡθ״𺦣ܳȣmmΪָ1020gkgʹҴγɡ

2.1.3.θӰ:۴40ֻ176±21gΪ4飬ʳ24СʱֱɺˮlСʱθ0.6N1mlֻٹlСʱȡθ״𺦣ܳȣmmΪָ8510gkgγɡ

2.1.4.ԽӰ죺۴20ֻ145±16g2飬ʳ24СʱŲֱʮָעˮˮϸں19Сʱȡθǰθ񣬷ָּ8Dʾ10gkgγ

2.2.θҺڵӰ죺240-300gԴ20ֻΪ顣ʳ24Сʱˮ󣬸ҩ鰴10gkgƤעעҺ2ΣмlСʱͬȻˮĩθ30ӣźϸڡʳˮ5hռȫθҺpHֵⶨȡɼٴθҺɽθҺȡ

2.3.θ˶Ӱ죺

2.3.1.θ:18-22gС21ֻ2飬ϵȽܵķθзӺΪָ꣬ſԽ죬θвԽ٣ܷdzԵθʡ

2.3.2.θ˶:Ʊθ걾̨ҺٲⶨǼ¼θ˶߱仯ҩǰձȽϡҺеζǵŨȴ5×l0(-3)g/mlŨȴ1×10(-2)g/mlʱθԷԻΪƣȾ½ñҺϴָܻζΡ桢θԷԻӰ첻ԣȻθζǺԶԿãΪ½Ƶʼ١

2.3.3.ԶҩСӰ:1.5kgң250gңѪ峦ʵ鷨Ʊʵ飬¼ԷƽȺⱻԿҩ̼ⶹѪƽȻƺ鰷¼ȶÿ3ӸǼ1Σ3Σ˶Կ鰷Dzõһ⣩ʹӪҺг3ҩۻŨȣÿθҩ¼3ӳܻ仯Ӷʾ7ҩСơ

2.3.4.ֹŻ:Ҹ30ֻ۲У300-400gΪ3飬ÿ10ֻʵֱǼˮˮݻθҩҩlСʱÿθ2%ͭ1ml100gء¼ÿֵһŻµʱ䣨ŻDZڣͭ1СʱŻµĴŻƵʣżټҸŻƵʣӳγŻʱơζһֹŻãͳƲš

2.3.5.ֹк:

2.3.5.1.ԱСкӰС36ֻ20.7±2.6gΪ3飬ֱθˮˮ30Ӻ೦0.15mlֻ¼кʵ̽ʳˮɼ10g20gkgٱĸкżóʱӳò

2.3.5.2.ԷкҶСкӰС30ֻ19.2±1.8gΪ3飬ֱ೦ˮˮ30ӹ೦кҶ0.4gֻ۲츹к8СʱɼǶԿкҶĸкߣò仺ʱϳ

3.ʧѪݿ˵Ӱ죺22ֻԱ𲻾У1.75±0.25kgWiggersѪƿʧѪݿģ͡ȫѪʼӶԵθҩעҺˮϡ0.5gml10ml/kg4Σmin3Сʱꣻˮ۲3Сʱ6СʱʣƽѪѹʺˮգѸٶݿѪѹӻѪѹ½Ӱ첻ԡҩ3СʱΪ1111ԣP0.05ڶ6116hΪ711ԣP0.05ڶ1/11ʧѪdzԵļ٣Ƚϣҩ΢֫嶶õĺ΢֫彩ԡ

4.Ѫ˨γɼѪܵãWister60ֻ۸룬185±25g6飬ݻˮˮ飬LD501511010-20g/kgθҩΪˮ顣ҩ1СʱⶨѪ˨γʱ䣬ȡѪⶨĿ飬עl00u/kgϷⶨˮ20gkgʱѪ˨γʱӳ10gkgʱѪøʱ䣨KPTTв̶ͬӳ20g/kgʱKPTTVFӳָԱ仯

5.ãCCl4շԸ𺦴SGPTSGOTӰ۴36ֻ222±25g4飬ÿֱθlˮˮ5죬ĩθҩ1Сʱˮ⣬ǻעȻ̼CCl40.3mlkgʳ16Сʱ̹¾ȡѪⶨSGPTSGOTɼ510gkgܶԿCCl4SGPTã5gkg鲻ܶԿCCl4SGOTá

6.ãСθ20g/kgˮżپʯŤ巴ӦӳȰ̼ʹӦDZڡ˱ǵļ״ˮȡﶼ5-ɫ׺ʾȥǼ5-ɫ弤ݱǹʵҴȡйϸV-79áӸֲзϸΪɫĩV-79ϸϸУֻдֻɫĩʾԵĻԡڽһϸ˱ʰKBܰϸѪϸP388ϸУҲֻдֻɫĩʾԡǵIC50ֱֵΪV-79Ϊ0.19mgmlKBΪ0.98mgmlP388Ϊ0.43mgml⣬ǹʵǼпȱá

ȡƷĩ0.5gҺl→10010mlҡӣ˹ȡҺ2mlӵ⻯Һ1Σҡɻưɫȡ˲1mlԶװȩҺ2mlˮԡϼȣҺӽ紦ɺɫ״ƷִͳСͳͳΣںɫѿڣŨСͳԲΣѰ겻ԣɫɫϵ

ơǣȡʲݼȥȡ뾻ǣҺΪȣ΢𱺸ɡÿ100øʲ64

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Ρɢֹʹʪ丹ʹͷʹʹʹŻᣬʪйк

÷ڷ1.5-5g衢ɢãĩ󣬻ˮϴ

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2.ܡйȼɡ

3.ݸĿ𣬻Ŀ

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6.ݻԡǣͣ併֮ҩҲ̶ԻСٸ֮ŻĶᣬظ̵۶ʳƢθͣйкƢʳСĶŻ࣬ǽԸƢ֤֮ҲǽԿ֮

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9.ũݾֹʹ溮ȣʪѪԣа

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