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2017-12-08 10:01 Ķ:

ȫвҩࡷé

ҩơé

ƴXin Máo

ӢRHIZOMA CURCULIGINIS

˿éɽءءǧء

ԴƷΪʯֲéCurculigo orchioides Gaertn. ĸڣȥͷϴ

״ƷԲΣ310cmֱ0.40.8cmںɫغɫֲڣϸ״ۼݺơӲ࣬۶ϣ治ƽ̹ɫغɫĴɫ΢㣬ζ΢ࡢ

𡿣1Ʒ棺ľ˨ϸ310 Ƥ㣬żάƤԵеϸƷƤԡάľͼͣɢС֯ɢжҺϸԲΣֱ60200μmں뾧50180μmϸ

2ȡƷĩ2gҴ20mlȻ 30 ӣ˹ҺɣӴ1 mlʹܽ⣬ȡҺΪƷҺȡéնƷӴƳÿ1ml0.1mg ҺΪƷҺձɫ׷¼ B飬ȡҺ2μlֱͬһ轺DZϣԴ״ᣨ10:1:0.1Ϊչչȡɣ2軯Һ2ȻҺ1:1ƷɫУƷɫӦλϣͬɫߵ㡣

ơééûƾưȣ͸΢ɣȡȫɡÿ100ûƾ10

ζȣж

龭ΡƢ

Ρǿǣʪ䣬ϥԣк

÷39g

ءøﴦù

ժ¼ȫвҩࡷ

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éͼƬ

ҩǵ䡷é

ҩơé

ƴXin Máo

ééצӡŲΣݡéݣҩԱҪ̦ݡ䷹ݣʱݡСظľ㷽ظҩԡéΣҩ־˿éҩéΡŻéҩ־éĴҩ־ءɽء֡ƽءɽҩٴࡷ

ҩݡ

ԴΪʯֲé24·ѿǰ79ήʱȡϴȥ͸ͷɹɡɹɡ

ԭ̬ݱӳɴ30ףԲ״ʣƤɫ׳ʣϾԡҶ36ƬΣ1025ףȶ˽⣬޷ӳɱ״410ף̰ɫԵĤʣҶë󽥹⻬Ҹ12.5ףҶڣԣϲΪۻ²ΪԻƬΣɫĤʣëֱԼ1ϻף²ϸ״Լ2׻ϲ6ѣƬΣ812ףɫɫгë6˿̣ӷëԲΣʣԼ1.2ףȶ๣ëԳΣɫ๣в״ơ68¡

ֲҰƽԭIJݵɽéݼâǴСֲա㽭̨塢㶫ϡĴݡϵȵءĴϡݣ⣬㶫ȵ

״ΪԲΣƽ310ףֱ38סغɫںɫֲڣƽϸܶĺƣɢвԵϸСԲ״Ƥסδȥߣڸһ˳ϸмֵԼ36ףмܵĻ״ƣɣ۶ϡʼ࣬۶ϣƽ̹΢ԣԳ͸״ƤdzɫʺɫĴɫ΢ζ΢ԸֳʼࡢںɫΪѡ

ѧɷ֡4֬1֬۵ȡ

ơéȡéûƾưȣ͸ù΢ɣȡɡÿé100ûƾ1020

١׹ۡ"ɵãéˮϴƤڻͭжȴϡʢڶˮнһޣȡþʪȡɡ"

ڡҩݡ"éʱУŴ"

ζ£ж

١ҩݡ"ζʣ΢ڣС"

ڡݣ"ζ£ж"

ۡϱݡ"£ζ΢̡"

ܡĿ"ȡ"

龭ξ

١ϱݡ"ζ"

ڡ桷"רš"

ۡ¡"Ρ"

Ρ׳ǡή䣬Сʧ©ĸʹԣӸңߣк

ϥ䣬Ե֢ŷ"é"׳ǡ澫Ŀ뷢䷽£ éŴˮн죬ȡﱣɡòˮн죬ȡƤɡȡƹéһһǰʮߣȥƤ㣨ʣȥǣػƣػƣһϸӾӣӴÿʮ裬ǰ¾¡һΡ

׳֮ϥʹθʹʳ

١ҩݡ"磬ůţ尲࣬ǿǣʳ""ɷˣĿ裬"

ڡջӱݡ"һзˣθ"

ۡݡ"ĸʳŷαԲУɷͣʧ硣"

ܡϱݡ"θ˺ѪӸңŧ"

ݡҩԱҪ"ֹʹΰǣ̵ʳʮɹɳDzغã糿ͣ׳뷢"

ޡҩ⡷"Ƥ񮡣"

÷ڷ1.53Ǯ衢ɢã

ע⡿߼ɷ

١׹ۡ"ޡ"

ڡݾ衷"һ鷢ȡԡѪѪѪѪѪܣžǣνʹϥףڸʹʧ־ˮԾߣ˹ʧѪ鲻ƫԣθаȲɱȣθ׼㣬⺮ʻˮ֤á"

ءøﴦù

éӣӸʵǮԡݲҩ

éһݾƷݲҩ

׳ǣ澫ĿéŴգȥˮ½գͭﱣɣȡһգƤɣȡһһǰʮߣȥƤ㣨ʣȥǣػƣȵػƣΪĩ裬Ӵÿʮ裬ʳǰ¾£նʥ¼é裩

ܶéޣɹɣŲһ֣һ֣mq롣ΪĩÿǮŴո򷽡ɢ

γβ֢״ĸѪѹéƢꪡ֪ĸưء飬ζȷ֣ŨҺշΣÿǮһҽоϻࡷ

θ˺Ѫѳ©֢éǮΪĩȫع顢߹ݸȷ֣Զζˮƽéĩ¡ϱݡ

Ӹһ𶾣ͷɫߣéж٣壬ˮƷߵ÷֮ŧŧϱݡ

ҧͬҩٴࡷ

ժ¼ҩǵ䡷


лݡé

ҩơé

ƴXin Máo

ӢCommon Curculigo Rhizome Rhizome of Common Curculigo

ééצӡŲΡéݡ̦ݡ䷹ݡСظظéΡŻéé˿éءɽء֡ƽءɽéΡǧءɽƤ⵶

1.ҩݡ

2.ͼé񴨡֮Ҷé鵣ݣлӻƣʵֱжϸ฽ưףƤԴ֣ɫ¡²ɸáɽţ̣½ӡŷéƣˣĿˡʱɵãӹȥƤ綹ޣ

ԴҩĻԴΪéֲéĸ

ֲﶯCurculigo orchioides Gaertn.[C.orchioides Gaertn.var.ninor Benth.]

պʹأéԺ2꣬10µĩѿǰڡѸȫ𣬶Ҷɹɡ

ԭ̬éݱԲ״ֱֱԼ1cmɴ30cmƤɫʣ߻״ƣɴ6cmϾԡҶҶƬΣ״λΣ10-45cm5-25mmȶ˳⣬ӳɱҶԣɢëẹ̈67-cm󲿷״Ҷ֮ڣ౻ëƬΣ2.5-5cmĤʣԵë״ٳɡ״ͨ4-6仨ɫֱԼ1cm²ͲΣϲ6ѣƬΣ8-12mm2.5-3mmֵıʱɢë6ԼΪƬ1/2˿1.5-2.5mmҩ2-4mmͷ3ѣѲֽϻΪӷȶ˾߳๣๳7.5mmëĴ״1.2-1.5cmԼ6mmȶг๡ɫ͹ƣ๡4-9¡

ֲ̬ں1600mµ²ݵػϡ

Դֲֲա㽭̨塢ϡ㶫Ĵݡϵȵء

ࡿѧ ϲů͸ɺΡѡɽ»ƽأɷֵɰࡣڵݵ֡ ༼ Ӻ͸ֳӷֳԷ9-10£ѡѿĸ꣬ٿҶڲ¹ʵӣϴ󣬻ʪϸɳرá3-4磬紲ϰо30cmϸǣԼ1cmÿ1hm230kg󣬼ʱݡˮ׷ʡ2ڴδǰ25cm×20cmѨ֣ÿѨ3-4ꡣֳѸг2cmСΣ紲Բʱ˵ֲ1-2꼴ԡ ʱ׷ʩˮʣԺи3-4ΡԽǰиݺ׷1Ρ2괺ļиݼ׷ʡ

״״ ԲΣ3-10cmֱ4-8mmںɫغɫ죬ݹϸ״ĴָۡӲ࣬۶ϣƽ̹Գʽ״ɫغɫĴɫһɫ΢㣬ζ΢ࡢ׳ɫںΪѡ ΢ 棺ⷽΪ4-7ľ˨ϸƤ㣬άƤԡάɢУƤ㴦нܣάľͻ֯͡ɢճҺϸԲΣֱ60-200μmں뾧Լ50-180μmϸڳ

ѧɷ֡é߰curculigosideAB¶߰orcinol glucoside¶-3-ľ߰corchiosideAé߰curculigosaponinABCDEFKLMéأcurculigineABCé߰ԪcurculigeninABCéƴcurculigol˿߰Ԫyuccagenin57-÷Ƥ-3-O-α-L-ľǻ4→1-O-β-D-߰57-dimethoxymyricetin-3-O-α-L-xylopyranosyl4→1-O-β-D-glucopyranosideʯlycorineN--N-ǻ-2-N-acetyl-N-hydroxy-2-carbamic acid methylester3--5-2H-3456--1--2356-ຣ3-acetyl-5-carbomethoxy-2H--3456-teTCMLIBahydro-1-oxa-2356-teTCMLIBazineNNN'N'-ļ׻NNN'N'-teTCMLIBamethylsuccinamideֺľϩcycloartenolβ-޴β-sitosterol޴stigmasterolʮһ鴼henTCMLIBiacontanolԼֳ֬廯3--5--31-ʮ̼ϩ3-methoxy-5-acetyl-31-TCMLIBiTCMLIBiacontene21-ǻʮ-20-ͪ21-hydroxyteTCMLIBacontan-20-one4-׻ʮᣨ4-methylheptadecanoic acid27-ǻ-ʮ-6-ͪ27-hydroxyTCMLIBiacontan-6-one23-ǻʮ-6-ͪ23-hydroxyTCMLIBiacontan-6-one4--2--5-׻ʮ飨4-acetyl-2-methoxy-5-methylTCMLIBiacontane25-ǻ-33-׻ʮ-6-ͪ25-hydroxy-33-methylpentaTCMLIBiacontan-6-one

ҩá1.߹ã1.1.ԾϸɹܵӰ죺Сé70%1020g/kgÿ1Σ7죬ڸҩ5ֱǻע0.4%ԭ2mlĩθҩlСʱǻע2%ѪҺ1ml2СʱС󡣰ף̷ҵȣҽѧԺѧ1979ⶨɹܡéʹСǻϸɰٷָȶӡ

1.2.߹СTܰϸٷʵӰ죺øϾҽѧԺ߽лҽѧ־1980ⶨСTܰϸٷʡ֤éСTܰϸٷʣԻ߹СTܰϸĽԵá

1.3.éˮдٽɲӳ书Чé߰ٽϸɹܣΪǿ߹ܡ

2.ϵͳã2.1.ͱ˯ʱӰ죺Сǻעé10gkg30ӣǻעͱ40mgkg¼С˯ʱ䣬ҩ飨ˮСƽ˯ʱֱΪ304.9±24.263.4±11.6ӣ֤éӳ˯ʱãP<0.001

2.2.ӡ¾õӰ죺Сǻעé30ӣٸǻעӡ200mgkg¼СԾʵDZʱ䡣éͶ־ʵDZʱֱΪ24.38±3.787.57±0.63ӣdzţP<0.001˵éӡСʣƳ־ʵDZڡ

2.3.éʯǻע5mg/kgӳDZڣʹ䲿ʧָСע2mg/kgŵãΪ12mg/kgӳͱ׵Ĵʱ䣬ŵʹͽá

3.--Ṧܵã3.1.-ѳڷڹܵӰ죺Դ35ֻ150-200gΪ8飺é顢˿顢顢顢顢޽顢Ͷ顣ҩ飨ҺԹθҩ1ml100gأÿ2Σ5졣θͬˮ6촦ͱ£ɸȡѪ1mlѪѪأLHⶨժǰҶӹѳأѳͶ֮Tris-HclҺⶨëĤټأ塣éҩʹǰҶѳӹȶأP<0.01Ѫлˮƽδı䣻ѳëĤټأҩȶҲߣP<0.01

3.2.ȥѳԴٻͷżطӦԵӰ죺ʵƲJohnson JHDavis CL1981ķȡ35ֻ꽡Դ150-200gг˫ѳ1ܺΪ8飬7ΪӦҩ飬1Ϊ顣ÿչθҩ2Σ1ml100gأ5죻ͬˮ68㣬ͱƤע50mgkg30ӺɸǻѪ0.4mlؿȻעD--ٻͷżأ100ng/100gأעٻͷżغ30Ӻ90ӣɸǻȡѪ0.4mlķ3ΣȡѪ֮ѪزⶨжעٻͷżغطڷӦ鶯ͱ£Ѫˮƽܵ͡עD--ٻͷżغ󣬶鶯30ʱѪˮƽӵ22.25ngml90ʱΪ18.50ng/mléҩĴ󣬴עٻͷżغطڷӦӣע90ʱѪˮƽéΪ55.90ngmlȶߣP<0.01

4.ԼãȡΪ60-90gԴ16ֻгغ裬7죬Ϊ2飬ֱθé70%10gkgˮÿ1Σ21졣ĩθҩĴգʳٳءéľطֱΪ0.116±0.0090.0679±0.003mggأŲ죨P<0.01˵éԼá

5.Ӧԭã5.1.ȱãСθé70%2040gkg1Сʱ󣬽С250mlƿУܷƿڣ¼СĴʱ䡣é20gkg40g/kgСĴʱֱΪ28.8±1.1433.6±1.1926.8±0.77ӣX±SEé40gkgԵĿȱãP<0.001

5.2.ãСǻעé70%10gkg30Ӻ󣬽45±1ĺڣҩСһΪ磬¼Сʡé20ֻС5ֻ25%20ֻСУ14ֻΪ70%ţP<0.05˵éпá

6.ãСǻעé70%10gkgɵ50mgkgˮҩ30԰Ͷסé顢ɵСƬͶȷֱΪ9.25±1.23mg4.1±1.35mg14±1.04mgéСʵ֢ԵãP<0.05

7.ԺϸĤNa+K+-ATPøԵãСθ12%éȲҩˮҺ6gkgÿ1Σ10졣ݻˮⶨøԡéȲҩNa+K+-ATPøĻԡ

8.ã100%ƽڹʷϡϡ˾á

9.ãéıͪȡ԰ϸˮʵáʯСˮϸͽ⣬ӰкڰϸһΪҪԴΪé԰ϸǴлһŹЧ

10.ãéˮȡҺŹǿġʧþע6g/kgʣʹͻϸ½ʹϵͳתøԼ20%ʹԼ80%ʹ״ٻܼˣѪĻ-ˮƽ߻-ˮƽ߻ؽ-/-ձֵǻעʯ6mg/kgйСøãȽѹʵԹؽס

ԡС1ιθé150gҩkg7һ˵éĶԺܵ͡

1ȡĩ1gˮ10mlݹҹ60ˮԡ½20min˹ҺɣҴ2mlܽ˹Һмӵ10%α-ҴҺҡȣصȱڵμŨᣬҺ洦Ϻɫࣩ 2ȡĩ5gȷ10ml½24h˹ҺŨ3mlȡŨҺ1ΣֽϣɺӫԵɫӫ⡣ʣŨҺɣҴ2mlܽ⣬ȡҺԹУ3%̼ˮҺˮԡ3-5min䣬صԼ0.5mlԺɫ㶹أ 3ɫ ȡƷĩ2gҴ20mlˮԡмȻȡ30min˹ҺɣӴ1mlʹܽ⣬ȡҺΪҺȡé߰ƷӴƳÿ1ml0.1mgҺΪƷҺȡҺ2μlֱͬһ轺GϣԴ-״-ᣨ1010.1չȡɣ2%軯-2%ȻҺ11ƷɫƷɫӦλϣͬɫߵ㡣

ơ1.éȡéûƾưȣ͸ù΢ɣȡɡÿé100ûƾ10-202.׹ۡɵãéˮϴƤڻͭжȴϡʢڶˮнһޣȡþʪȡɡ

3.ҩݡéʱУŴ

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Ρ׳ʪή䣻Сʧ丹ʹϥʹ֫Σۺ

÷ڷ3-10g衢ɢơã

ע⡿1.߼ɷ

2.׹ۡޡ

3.ݾ衷һ鷢ȡԡѪѪѪѪѪܣžǣνʹϥףڸʹʧ־ˮԾߣ˹ʧѪ鲻ƫԣθаȲɱȣθ׼㣬⺮ʻˮ֤á

é衶ʥ¼ɢ򷽡

1.Ŀéȡ֮ҩҲΩ֮׳ʢߣ֮ܶ

2.±ࡷéߣһƬ⣬ôҲҩϲ֮ԡݡҲȻȫȻé£ֹ֮֮ܳʧ磬ˡνȫߣé֮ԣ븽ӡ죬é£޷֮ڱվڶ𣬱վ򾫲йֹߣȻӡʣʹ֮侫ߣ֮侫Ԫ˥ߣɻ֮˵éҩ֮Ҳ

3.桷éعרůԪ˥䣬ʧӣ䲻ʳԲУҲ֮Ч侫Ϊլ˥Ѫ˥Զ治£Զʧ򲻽ӡ븽ơ͡ƹֽ޽ߴӡԶ־ͬΪһԳ˥ʣͨѪֺͣԳ˥ޣ޽Գ˥䣬ߴ˥ʪԳ˥ᣬƹֽ˥кԶ־Գ˥磬ΩͬЧδ䲹Ҳʷ˥֮븽֢Ȼˣʢ֮ܶΪϲ⡣

4.塷éDz֮רҩԣ졢Ƣֹ֮࣬ΩߣΪ֮ãزΪ֮Ʒֳɷ֮ͣνͣ麮֮ѡýеȷǧ𡷡̨ҩּɼ֮Ͳ෴νǣƣֳĿ裬֮ΪѵҲ

5.ҩݡ磬ůţ尲࣬ǿǣʳɷˣĿ裬

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