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2018-10-24 15:57 Ķ:

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ƴXn Yí

ӢFLOS MAGNOLIAE

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ԴƷΪľֲMagnolia biondii Pamp.Magnolia denudata Desv.Magnolia sprengeri Pamp.ĸĩδʱգȥ֦ɡ

״ƷʳΣëͷ1.22.5cmֱ0.81.5cm߶̹Լ5mm,ɫ״ƤסƬ23㣬ÿ2ƬƬСѿƬܱҰɫɫëڱɫëƬ9,ɫֻƬ3,ΣԼΪֳ1/4,Ƭ״ֻƬ6,ÿ3,״Сʹ״Сᣬʴࡣ㣬ζԿࡣ

1.53cmֱ11.5cm֦ϴ׳ƤdzɫƬܱҰɫɫëƬ9,ͬ͡

䵱24cmֱ12cm֦׳Ƥ׺ɫƬܱɫ򵭻ɫëеƬëʺںɫƬ101215졣

𡿣1Ʒĩɫ򵭻ɫë࣬ɢڣϣ24ϸеϸں413μmϸ̴ϸڼʯϸʯϸȺԲΡλ֦״ں420μm׹ԣǻпɼػɫϸ϶࣬ԲΣеĿɼ΢С͵ΡƬƤϸⷽΣܱ״

2ȡƷַ1gȷ10ml30ӣ˹Һɣȷ2mlʹܽ⣬ΪƷҺȡľ֬ضƷӼ״Ƴÿ1ml1mgҺΪƷҺձɫ׷¼ B飬ȡҺ210μlֱͬһȼ׻άΪϼĹ轺 H ϣȷ-ѣ51Ϊչչȡɣ10ҴҺ90ߵɫƷɫ,ƷɫӦλϣͬϺɫߵ㡣

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Ρɢ纮ͨϡڷ纮ͷʹԨ顣

÷39g

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ע1ֲֵͬĻڲͬҲҩģľMagnolia liliflora Desr.[M. quinquepeta Buc’hozDandy]Ӧ»Magnolia diva stapf[M. denudata Desr. var. purpurascens Rehd. et Wils.]ľMagnolia campbellii Hook. f. et Thoms.ɻMagnolia grandiflora L.

2Ʒξͨڱǣɢ纮ٴƱǶ顢ıԨ֢ơϸ硢ԶӵӦá

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򡢺ҡľȪӭʰšľʻ񱾲ݡëġңɽҩ־ӻĴҩ־

ԴΪľֲһ紺δʱժȥ֦Tɡ

ԭ̬ģľš¼ľ

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Ҷľߴ15סΣ֦٣֦ëҶҶ12.5ףëҶƬΣ״ԲΣ816ף510ףȶͻ⣬ȫԵɫϱë浭ɫҰɫëѿë󣬵Ҷţ״ֱ1015ףɫɫɫֶ̣ƺɫë뻨ƣ9Ƭλ״ԲΣ˿ƽƤΣӳĻϡʵԲͲΣ710ס2¡67¡

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ֲȫ󲿷ֵвϡĴա㽭ȵء

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ѧɷ֡ٺӷͣкȩͷӣ18-ҶءľҶ͹ʵҩص߰

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ڶԺƼ

еᾧֱܸ걾ϣмãˮ෴áòͬȡ걾Ƚ飬֤ձĻͬǰýǿ

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ڴ󼰼ӹλӹӹܵʵУ֤ļӹ˷ãδӰѪѹִ֮ܳáν˷ӹɷΪˮҴķǻӷʡ

1530ļԶ²áԶоֲãĽܵձM.kobusܰĤײ⡢ڣСƤעԵĿá

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ջӱݡ"ҩ΢ˣѿӣл߲ѡ"

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ۡҩۡ"֬ã⻪"

ܡջӱݡ"ͨĿͷʹ䡢"

ݡϱݡ"©Ԩ磬߱Ϊĩ溮ʹθʹ"

ޡĿ"ԨϡǴǴĩаպΡ"

ߡҩ⡷"йν棬ա"

ࡶҩ"ܴٽӹߴá"

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١ݾע"ܺ˕Ϊ֮ʹʯ֬ηѡѻơʯࡢƻ"

ڡݾϡ"˼ɣͷʹѪ߼ɣʹθ߼ɡ"

ۡݻԡ"֮ˣżз纮ϲͨߣá"

αԨİԶӶǮ룬һҶǮϲɹɣΪϸĩÿǮôСʳԶɢ

αסףǮͬ󣬳Ե鷽ѡࡷķݣ첻ʳһݡˮ48Сʱȡˮαǡ㶫вҩѡࡷ

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ͷѣðŻ̵һưġǡ顢ɽܺǮΪĩˮΪ衣ÿǮ¡ݻԡ

ٴӦáƱףȡ50ô3ˣҺŨճ״࣬20ˮë֬ϵȣټӷʿ100˵ȼࡣʱ12x3׵ɴǻ±Ǽʴɴʱȵ1غ롣ɴ֮һӦ¶ڱǿ֮⣬ճ̶⻬ڡ23Сʱȡÿջ1Σ10ΪһƳ̡һ45κͨʼת10κʼЧġǻͨת510Σڹ̡ƷʴԱ1002۲죬Ȭߣǻͨãͷʹʧ٣ǼѲʴ44ߣͨǼ׷ʴǰиƣδ.ȫ44ЧߣһƳԾ֢״޸ƣ12⣬ɽƳɼͼͺϼȣ͸ǡ228˴εĹ۲죬ԷʺԱ׺ͼԱ׵úԣһŨЧѣͼִ֮֮ͺϼϲ

ע⣬ֲͬĻģصԵĻġ

ժ¼ҩǵ䡷


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ƴXn Yí

򡢺ҡľӭľʻëġӻ

ԡũݾ

1.Ʊݡģδʱ֮¡ºòɡҶҶڽСʵҩҲ

2.塷к϶һһɫߣһߣҩɫߡ

3.ݸĿĻ֦ͷ磬ٲͷë˳̣Сյϰ棬㡣аɫߣ˺Ϊ

ԴҩĻԴΪľֲ䵱ȵĸﻨ١

ֲﶯ1Magnolia biondoii Pamp.[MFargesii(Finet et Gagnep.)Cheng2Magnolia denudata Desr.[MHeptapeta BuchozDandyMObovata Thunb. Var.denudata DesrDC]

3Magnolia sprengeri Pamp[MDenudataRehd Et WilsVarPurpurascensMaxim Rehd Et WilsMDenudata Rehd.et wils.varElongata Rehd.et Wils

պʹأ13£뻨δŵĻ٣ɹ϶ѳɶⷢʹʪһ¡ɹɸʱѷ12dɹȫɡ죬ɺɡ

ԭ̬1.Ҷľ6-12mС֦ɫػɫ⻬ҴëѿΣƬɫëҶҶ1-2cmҶۣҶƬԲ״λ״Σ10-18cm3.5-6.5cmȶ˽⣬ԲλШΣȫԵɫ⻬浭ɫëҶţ֦ϡҸ״ֱ6-8cmɫϺɫ㣻ֻ3Ƭ״ΣԼΪķ֮һСֻ3Σ4-8cmԼ2.5cm쳤Ļ²״УڻϲۺϹԲͲΣŤ8-13cmܳǣܳͻľʡӵΡ2-3£9¡

2.ڣС֦׳ëҶƬͨΡΣȶ˿Բƽػ԰ȱ߼̼⣬ШΣҶҶаɫϸë9Ƭɫʱɫ״ԲΡ2-3£8-9¡

3.ڣҶȶ˼⡢ͻСͷƬ12-14õɫϵɫơ3£6-7¡

ֲ̬1.ں400-2400mɽС

2.ں1200mµijҶҶҶ콻Уͥ԰ձࡣ

3.ں1300-2000mij̡ҶҶ콻С

Դֲ1.ֲϲࡢĴȵء

2.ֲڰա㽭ϡ㶫ȵء

3.ֲࡢϡĴȵء

ࡿѧ ϲůʪ򣬽ͺͺɻˮǿ͸ɺѡ㡢֡΢ԵɰΪˡ

༼ ӡ޽ӡǤ己ֳѹֳӷֳӦѡ15Ͻ׳ĸ֣òӣ3СѮ紲ϰо33cmԼ34cmĹӰ3cm빵ڣ빵ƽѹʵҪ񣬾ˮʱиݣϽˮʩϡˮصȡ2꣬ɶֲ޽ӷֳѿӡ֦ӣнӡӣɣľĴѿӱ֦ӳɻʸߡڳѿȷǰ^ҳѿΪˡľ23115cmľʵΪţӦѡһ׳֦ϵıѿ壬ѿӷǤ己ֳ5³6Ѯѡĵ׳֦10-12cmҶ2Ƭ¶пѿ࣬10-3ᶡҺпպһ£漴Ǥ塣紲øɾʪɰɣ15cmx4cm룬ʹҶƬһߣصء͸ˮϱĤǣٸDz񡣲ɻҪڳݡ׷ʡ1꼴ɶֲһ^Ҷ紺ѿǰֲ

ֲǰÿġи1ΣӲݸǸʡֲʱӦʩʣڶʩѷʣڴʩˮٽľѸٳ֡ʼÿӦڶʩƣʹ׳ࡣΪ˿θߴ󣬰ɣɳ1mʱȥѿʹֲ֦ѡ3֦ķչ̡֦һ㲻֦2025cmÿ޼ԭǣ֦ΪؼΪԽ֦Ϊ֦Ϊ8ѮҪעժģƶƣ֦

溦 м50׻в10001500Һע溦д꣬ɲɱ

״״1 ٳΣëͷ12-2.5cmֱ08-15cmľʶ̹Լ5mmɫ״ƤסƬ2-3㣬ÿ2ƬƬСѿƬܱҰɫɫëڱغɫëƬ93֣غɫֻƬΣԼΪֳ14Ƭ״״ڻ²˿ƽҩΣ״ڻϲᣬʴࡣ㣬ζԿࡣ

2 ٳ15-3cmֱ1-15cm֦ϴ׳ƤdzɫƬܱҰɫɫëƬ9Ų졣

3䵱 ٳ3-4cmֱ1-2cm֦׳Ƥ׺ɫƬܱɫ򵭻ɫëеƬë䣬ʺںɫƬ10-15Ų졣ҩľԻٴδšɫ̡֦Ϊѡ

΢ Ƭ£棺1 Ƥϸ1Уʯϸ״ë1-3ϸƤϸʯϸȺʯϸԲΡλ򲻹Σ30-80μmֱ30-40μmɼơάС貿ϸʯϸȺ

2 Ƥϸβʯϸ״ںɫɫأ޷ëƤʯϸ϶ࡣʲλʯϸȺС貿ϸ

3䵱 ƤϸԳʯϸ״޷ëƤͻά貿ʯϸ٣ϸ϶ࡣƷʱ־л񹲺͹ҩ䡷1995涨ƷӷͲ10mlg

ѧɷ֡1 ٺӷ34ɷΪβ-ϩβ-pinene18-Ҷأ18cineoleԣcamphorα-ϩα-pineneα-β-ˮϩphellandreneϩsabineneα-γ-ϩterpinene嶡tertbutylbenzeneˮϩsabinene hydrate㴼agarolα-β-ʹterpineol4-ʹ4terpineolβ-ϩβ-elemeneʽʽĶϩcaryophyleneβ-ϩβ-selinenβ-γ-δ-ϩcadinene鼴torreyol[1]ݱٵĸƷӷ225ɷΪα-β-ϩ18-Ҷأϩα-ϩ¹ϩmyrceneα-ϩα-limonene4-ʹϩcampheneϩcareneα-γ-ʹterpineolˮϩɡأcymeneα-ϩ׻ϩͪmethyl heptenoneԣbornyl ac-etateϩα-إɣϩα-humulene˫ϩbicycloelemeneȩcitralabécitronellolţgeraniol׻ͷӣmethyleugenol㴼elemol鼴Ȼ崼nerolidolϩcubebeneϻfarnesol-ϻȩfarnesallinaloolʽˮϩtranssabinene hydrate8-ϩڱdiethyl phthalate[2]ȡٻľɷ֣֬Ӷѣpinoresinol dimethyl etherأmagnolin֬Bѣlirioresinol B dimethyl etherأfargesinչ֬أaschantinȥչ֬أdemethoxyaschantin[3]֬أbiondininA4ݣ֬أdenuda- tinB,֬ͪfargespone)ABC[14]

2. ٺͻֱ𺬻ӷ029067008009ɷ18-Ҷأα-β-ϩϩϩβ-¹ϩϩԾɡأp-cymene˳ʽ3-ϩ-1-(3-hexen-1-ol),ʽʽĵķlinalool oxideʮ飨npentadecaneα-ţͣϩα-copaeneβ-Բϩβ-bourbonene4-ʹβ-ޡα-ʹα-ܳɣϩα-γ-ϩmuuroleneţϩgermacreneDa-éαcit-ronellyl acetateβ-ϩᠽţgeranyl acetateα-γ-δ-ϩţԾɡ-8-p-cymen-8-olϩcalameneneʮ飨nnonadecaneϩcaryophyllene oxideʽȻ崼transneroidol㴼β-Ҷβeudesmol[5]ȡͪɷ֣ܿ߰rutinƤ-7-߰quercetin-7-glucoside[6]Ҷӷ004015ɷβ-ϩͳȻ崼ɷ뻨ƣٺʮ飬ʮ顢Ծɡ-8-ຬα-ʹγ-ϩβ-ϩ[4]Ҷлľ֬ɷ֣֬أdenudatinAB֬ͪdenudatone飨burchellinϸҶήϩͪfutoenoneεɭveraguensin[7]Ƥӷͣɷ18-Ҷأ4-ʹα-ʹ[5]Ҷľsalicifolineľmagnocurarine[8]

3䵱 ٺӷͣɷʽϩϩβ-Ҷα-β-ϩϩ¹ϩϩҶأγ-ϩԾɡأԣȄϩϩaromadendreneϩeremophilene˳ʽʽ-β-ϻϩβ-farnesene-ϩarcurcumeneγ-ϩα-γ-ϩéϩ׻ͷӣ㴼γ-Ҷأ鼴[9]ӷ10ɷ¹ϩԾɡأα-β-ϩϩthujeneϩγ-ϩ4-ش4-thujanolϩ2-ԣܳϣϩ-4-p-2menthen4-ol14Ҷأ14-cineoleδ-Ѵδ-cadinolԣ3-ϩ-2-ͪ3decen2one4-ʹα-ʹsabinol1-(ܳ)ϩ-3-p-1menthen3olȩpisopropylbenzaldehydeţԣisoborneol14-ϩ14cadaladieneα-ϩӣthymolα- ţͣϩαβ-γ-δ-ϩα-ϻϩȄϩβ-ϩϩcurcumeneα-ϩ-α-ţͣ-8-dihydro-α-copaene-8-ol[10]ȡƤӷͣҪɷΪβ-Ҷ[11]ƤҶľľ[1113]䵱ľmagnospren gerine[12,13]

ҩá1.ֲ̼ãĻӷƳɵķˮýĤУĤѪšѪͫ΢󣻵õƤ֯ճĤϣɲһɫ̱Ĥţ΢ѪΪš1114Ƥ¸ҩнãıҺע񾭴ɲáĴ(3.75gҩkg)ڴʮָҩ۲ҩǰճĤѪҩ30ҩǰȽԲP0.0560ʱճĤѪơ

2.־ãԹܷⶨĵMIC(mgml)ϾΪ3.13-6.25(ˮ)6.25-12.5()˫Ϊ39.5(ˮ)4.69()ŧ˾Ϊ18.75-75(ˮ)75-300()־ϾΪ150(ˮ)300()󳦸˾Ϊ37.5-75(ˮ)150-300()ԻҺС֢ԵĿãˮļΪ1gmlΪ0.75gmlȽP0.01

3.ʹãĴ6.5gkgˮ15gkg۲СȰ巨ʹáҩ60-240ʹֵӣP0.01ˮ240ʱԲ죬P0.01

4.ѹãĵˮעǻע䣬ȮèüнѹáעԲȮҲֽѹlg(ҩ)kgʱѪѹ40%ϣעɼһԺ˷ĶʵԸѪѹнѹãԸѪѹȮЧԣԭԸѪѹԵĽѹЧѹɷȥˮҺת֮֡ڽѹԭ棬ϵͳϵֱ࣬رѪԼ񾭽϶ڷʱѹòԣЧɷֲױյԭʡľнѹá

5.ԺƼãеõķܵĸֱ񾭷콳걾ϳּáֱܸ걾飬ˮáòͬȡ걾Ƚ飬֤ձMagnolia salici-folia Maxim.Ļͬǰýǿ

6.ӹƽãӹȮλڹڹܵУ֤ļ˷ӹδӰѪѹͺļʱעθҩáθ1-2.4gkgʱ20-60Ӻãɳ8-24Сʱӹδ߸ΪС˷ӹɷΪˮҴķǻӷʡ

7.峦Ӱ죺ȡԳֱ2-3cmװ뺬20ml̨ҺԡУ۲Ķ鰷1×l0(-3)ֱãĴ5×l0(-3)ˮ2.5×10(-3)ҩgmlв̶ͬȵĿ鰷á

8.ã

8.1.Ӧ(SRS-A)ã203040μgmlŨȣSRS-AسID50Ϊ30μgml40gml׿SRS-Aá

8.2.10203040μg/ml鰷׿õID50Ϊ18μgml

8.3.60μgmlпس(P0.01)

8.4.ҩʵ鷽ѧ(1985)200mgkgһǻע90Ӻ۲áԵı(P0.01)

ԡ1.ԣĶԽϵͣȮע1gkgþע4.75gkgδ(ȥ)ǻעLD50Ϊ22.5g(ҩ)kgСΪ19.9g(ҩ)kgǻע󣬶5-10߶ԺתֶǼѪţ礣ʶ1-2hڲ߿𽥻ָϲ(M.Biondii)СθLD50Ϊ38.21±5.2g(ҩ)kgĴ(M.Sprengeri)Ϊ93.55g(ҩ)kgˮŨȺδԡҶľļLD50СǻעΪ171mgkgעΪ46mgkgþעMLDԼΪ50mgkgԭҪǺԡ

2.ǼԶԣ贼18g(ҩ)kgˮ30g15g(ҩ)kg󡢿ڷlmoȽϣ鼰Ƭδ쳣仯

ơ֦ʣãҩ΢ˣѿӣл߲ѡ

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Ρɢ纮ͨϡԨ纮ð֮ͷʹ

÷ڷ 3-10g˰壻衢ɢãĩǣˮαǡ

ע⡿1.

2.ݾ衷˼ɣͷʹѪ߼ɣʹθ߼ɡ

3.ݻԡ֮ˣżз纮ϲͨߣá

1.ݸĿοڱǣθǶУΪԪ֮Ϊ֮ϣ֮㣬ͷΪ֮㣬Ϊ֮֮Σθͨ죬ͷĿ֮

2.ݾ衷ģ庮ȣͷʹҰ⼡ͨʹߣԶܷа£⣬̫Ƥëа֮ˣƤë⣬Դ࣬ΪȣֱΪ֮ϣͷΪ֮ף֮ͷ棬Ϊͷʹᡢʹܽ⼡ɢϴͷĿ֮а֤ӡѣðڳ֮ߣҡ֮Ҳаɢ£ͨӡ֮ˣë䣬ʪ֮θ棬ɢʪ뷢ȥӡ

3.±ࡷģͨ϶ᣬ()Ԩ֢֮ã֮Աÿɶɢ֮ãˣöɾҲ

4.衷庮ȣͷʹߣϲ磬Ҳ庮ȣͷʹߣа⣬͸ҲΩͷʹ֮庮ߣ˿Ρ

5.ũݾ庮ȷ磬ͷʹ

6.ҽ¼н⼡ϣͨʹѣðڳ֮ߡ뷢ȥ׳档

7.ҩۡ塣֬ã⻪

8.ջӱݡͨĿͷʹ䡢

9.ϱݡ©Ԩ磬߱Ϊĩ溮ʹθʹȾƷ

10.ݸĿԨϡǴǴĩаպΡ

11.ҩ⡷йν棬ա

12.ҩܴٽӹߴá

ժ¼лݡ

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