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2017-06-08 16:41 Ķ:

йҩ䡷

ҩơ

ƴZh Lín

ӢPOLYPORUS

Ұ

ԴƷΪ׾Polyporus umbellatus Pers.Friesĸڣȥɳ

״ƷΡԲλ״ез֦525cmֱ26cmɫҺɫغɫ״ͻᣬӲɫưɫԳʿ״΢ζ

𡿣1Ʒ棺ȫɾ˿ܽ֯ɡ2754μm ˿ɫ׷룻ڲ˿ɫֱ210μmеĿɼз֦ʽ״󡣾˿ڶƷΡ˫׶λ򲻹壬ֱ360μm68μm ʱᾧϡ

2ȡƷĩ1gϡ10mlˮԡ15ӣ裬𤽺״ȡƷĩҺ1→5裬״

ơȥʣݣϴ͸кƬ

ζʡƽ

龭׾

ΡˮʪС㲻ˮףйкǣ¡

÷612g

ءͨﴦ

ע1С㲻ˮ׵Ȳ֢ߡкƷͬãɢ䰢ʯͬãʪע£ʪܲʪйк֢ˮʪҩʪҩͬá

ժ¼йҩ䡷


ߵͼƬ

ҩǵ䡷

ҩơ

ƴZh Lín

㣨ׯӡoʺңׯӡ˾עgߣ輯ңͼҰʳҩֲ־ʺߣĴҩ־

ԴΪ׾ֲĸϷȫԲɣġΪࡣڳȥɰɹɡŸͨ紦

ԭ̬˳ʳο״򲻹״еijʹ״Ա⣬氼͹ƽغɫںɫƼ״ͻ𣻶ʰɫ򵭺ɫľʻᡣʵӵ¾֦γһԾǣɡγɡ״ԲΣֱ15ϡʣɺӲ࣬ԲΣ18ףв״dzɫɫⱡɫͬɫܿڶΡ΢³ԲΡ

ɽĸϣϲ͹׳ݵУ꼾͹һͷĢ״ʵ塣

ڵ£磬Ѱҽѡݺӱ飬ߵĵط֣ڣˮ͸Ҳ죬СԸ

ֲֲӱϡա㽭ϡĴݡϡɽࡢຣɹżȵءϡӱĴϡࡢຣ֡ɹšȵϲϴѡ

״ΪIJijο״Բο״СϸȣεĶ֦罪Լ1025ףԼ38ףԲ״ֱԼ37סҺɫغɫȫ״ͻԵơʼʵľϸ壬ɫɫԳʿ״ޣζԸƤںɫɫ۰סΪѡ

ѧɷ֡޴ءࡢʡ

ҩá

˿ڷ߼5ˣ6Сʱ62Ȼ453˼ٴδ֤ʵáԲĴȮʵ飬߼0.250.5/ᄇע򣬿ڷע0.0048/áÿڷǻע䣬ӽ˵ʼЧ2/ЧڷˮҺгٵĴ߼ƤͪãεйӰ졣ߺߣ30ˣ಻ϡѪҺÿСܶԵʺˮաɢߡߡк֦עȮͬʱơءӵųˮҺڷԵãҩԹ֦

ڿ

ߵĴȡҺԽɫ󳦸˾á

ơϴɰƬɡ

׹ۡ"ɵߣͭϴƤһأУ¶ˮһҹϸУҶһգȥҶɹá"

ζʵƽ

١"ζʣƽ"

ڡҩۡ"΢ȡ"

꽣"ʣƽ"

龭Ƣ׾

١Һݡ"̫"

ڡҩƷ"Ƣ׶"

ۡݾ⡷"̫ξ̫Ƣ"

ΡʪС㲻ˮйкܡǣ¡

١"űˮ"

ڡҩۡ"˺ߴȣͣʹ"

ۡҡ"йֹʣס"

ܡҽѧԴ"ʪҪƣȥİÑ"

ݡҽѧš"ʡ"

ޡĿ"ܡסǡ£ܣС㲻"

÷ڷ24Ǯ裬ɢ

ע⡿ˮʪ߼ɷ

١ҽѧԴ"ߵҺʪ֤"

ڡҽѧš"ʪ֢߼ɡ"

ۡ䱾ݡ"Ŀ衢ʪʣ߽á"

ȣˮС㲻ߣȥƤߡкʯ飩һζˮζȡȥңɰ·ߺϣ˺ۡ

ӽףС㲻΢ĩˮذĸ¼

ű¾ãһǮǮǮʲһǮƬöˮ룬һ롣δǰټ壬ұ

γθʪк޶ȣԲʳߣȥƤⶹޢȥǣڣöưأȥƤˣһ֡ζΪĩ裬̶ÿʮ裬ʳǰˮ¡ʥ¼裩

ܣɸ԰ϣͷذΪһذҹת֮ɢСƷ

׳ʢŰǣһһϰ綹ΪĩȽijɫȥ𶾰գȡΪĩһĩȺ裬ͩӴ󣬸ĩ裬ʹɣ벻ɰƿ֮ÿʮ裬¾£δ¡裩

Ż¶ϣ˼ˮߣߡߡȷ֡ζΪɢذҪԡɢ

˺ڿʡߡߡкʯһˮɶÿߺϡһΡ˷""

ͨС㲻Ϊ룬ÿһףˮ¡һΡ

׿ʣۦףС㲻ηͬϡ

١塷"ߣˮ֮࣬÷Ŀ"

ڡҩķ"ߣйͣϣܳʪС㡣"

ۡĿ"ߵܽܿС㣬ͬ벹ҩҲ"

ܡݻԡ"ߣʪˮֽ֮ҩҲҩζʵ΢࣬½ʵɢܽƿ֮С㣬ǰűϷ˺ߴȡܷа˷֮ҲϷͼʹаÑűк˷֮Ҳپ̫ȡʶС㲻ߣɢֹ£ʱԣ溮ű״ߣΪ̵磬ɢԶԡߣ֮Ҳ"

ݡҩƷ塷"ζƢͨˮˮкʪкͨܳʪˮףƻ㣬ΪݣͬΪҩʵƢйҩƢҩůƢͬҩƢƢߣйԪ֮"

ޡ"ƣʪƢθߣߡкԷ֮Ҳߴν΢ǣҲкνǣҲζ˺Ϊ"

ߡɳҩ⡷"ߣйˮ֮߸ݡˮ֮ΪԣľܶСɢ֮ˮа֮ʪҲ֮ˮаľҲ֮ˮа֦֮֮ľҲζ֮ˮй֦֮ľػ֮Ҳͽ򡢻֮湦"

ࡶ桷"ߣߡߵȷôˣкͬȳʪˮȻˮƢˮߣкͬˮȻԾӶ࣬棬λȻвڡغкͬãʾƫ֮ӡʪԿȥȻУѪ½кˮףűֹҩаʪڱգ޲Ϊ֮裬С㣬iԹҩУֹкüߣν˶ר˾ˮҺ׺ģ÷Ŀ"

ע׾ֲ߾ľˣڷȵɻʱ˵"ߵ͸.....ͬ벹ҩҲ"

ժ¼ҩǵ䡷


лݡ

ҩơ

ƴZh Lín

ӢAgaric

㡢oʺҡ˾롢gߡҡҰʳʺߡߡҰ

ԡũݾ

ԴҩĻԴΪ׾ߵľˡ

ֲﶯPolyporus umbellatus(Pers)Fr.[Grifola umbellatus(Pers.)Pilat]

պʹأϷȫԲɣġΪࡣڳȥɰɹɡŸͨ紦ڵ£磬Ѱҽѡݺӱ飬ߵĵط֣ڣˮ͸Ҳ죬СԸ

ԭ̬״򣬳ʴСһſ״ʵϺɫж͹ƽƣڲɫСһΪ3-5cm×3-20cmʵڵµľϷбη֦γһԾǣֱɴ20cmԲΣֱ1-4cmв״еɫάƬɫdzɫ޻ƣԵ񣬳ھʣɺӲࡣⱡɫܳԼ2mmͬɫӡܿԲΣÿ1mm3-4ɫ⻬ԲͲΣһԲΣһ⣬7-10μm×(3-4.2)μm

ֲ̬Եϻľ׮ԡ

Դֲֲں֡ӱɽࡢϡĴݡϡ

ࡿѧ Ұں1000-2000mɽشСҹϷ£»¡5cmĵ8-9˿ʼȷƽ14-20ʱ죬ȷ࣬22-25ʱγʵ塣͸ֳʺߡƫԵɰˮ30%-50%ۻ(Armillaria mellea)Ӫߵİֲۻйأ롢ʡܡ㡢Ůӵһ

༼ ߲ðҰ࣬ѡۻܹĹľ֡н֣ѡòֺ;֡ڽϵѡ񺣲1000-1500mƽ̹Ϊ۵ؼ15°ҵĻµأΪϷֵɰӦۻ֦ɲۻľ֣Ҳ˹ۻ֦ѡֱ1-2cmĿǶֲPҶ֦б10cmСΡֱ50-60cm30cmӣӵһҶõ֦֮䣬һȻ󰴴˷ظڼ㣬ÿһɰڷ5-7㣬ڿӶ3-5cmҶǡ賣ˮʪԼº֦ۻ˿ƾ֦ѡֱ2-3cmľ֦ɳ30cmҶ̽ڣΪ֣֦ķģߡ߾ӦѡʢҺɫߡڹľ10cmСѨѨӦݺύëѨʪҶһ㣬Էһھģ߾˷֮䣬ÿѨ100-250gȻһʪҶƽѨٸһϺҶ

ֺ˷̤ļɺˮࡣÿ괺ѨӸһҶɼˮлʣ

״1.״ ˳ʲ״ΡԲλ״ез֦5-25cmֱ2-6cmɫҺɫغɫ״ͻᣬӲɫưɫԳʿ״΢ζԸƤɫɫסΪѡ

2.΢ ĩưɫ˹ҺװƬɼɢڵľ˿ճľ˿ſ顣˿ϸз֦ϸһн״󲿷ֱ֣1.5-6μmϡ13μmɫɫɫɫ˿ϴ֣ڲԡƷ࣬˫׶壬ҲгʲΣֱ3-60μm68μmʱɼᡣĩˮȩҺճɽ״

ѧɷ֡˺ϾǢ໯׾ͪ(polyporusterone)ABCDEFG4681422-ϩ-3-ͪ[ergosta-4,6,8(14),22-tetraen-3-one],25-޺ͪ(25-deoxymakisterone)A,25--24(28)-ȥ޺ͪ[25-deoxy-24(28)-dehydro9makisterone]A,7,22-Ƕϩ-3-ͪ(ergosta-7,22-dien-3-one),7,22-޶ϩ-3-(ergosta-7,22-dien-3-ol),5,7,22-ϩ-3-(ergosta-5,7,22-trien-3-ol),5α,8α--622-޶ϩ-3-(5α.8α-epidioxyergosta-6,22-dien-3-ol),α-ǻʮ̼(α-hydroxytetracosanoic acid)

б߾˿ҺжD-¶(D-mannose)D-(D-galactose)D-(D-glucose)ɣĦΪ20:4:1

ҩá1.ã߼൱ҩ0.25-0.5gkgעע䣬ԲȮбȽԵãܴٽơȡصȵʵųСջܵĽ

2.߹ܵӰ죺2.1ǿã߶ǿСTϸConAֳӦԼBϸLPSֳӦ߶ǶСȫƢϸԵĴ˿á12.5mg(kg· )£߶ǿСSRBC쿹ϸǿСƢϸٷͳӦԼٽƢϸϸTϸ(CTL)԰ϸɱˡCTLǻ߼ӵҪЧӦϸойؼá

2.2һַTϸԴ˿á

СƢϸϸƢϸȥϸƢϸ۲ԲͬŨ߶ǵֳӦƢϸ߶ǵķӦСϸ𣬼Tϸڴ˷ӦвãƢϸȥϸµϸBϸܶ߶ǷԵֳӦ߶ǾBϸ˿ѵáƢϸȥϸ߶ǵķӦȴԼ˵ϸƢϸ߶ǵķӦоһĸáʾ߶ǿһַTϸԴ˿ءѪãͬPHAConAֲԴĴ˿ء

2.3СѪҺANAEܰϸӰ죺Сÿ츹ǻע߶2mg0.2ml7졣ʵǰȡѪͿƬa-øANAETܰϸⶨٷʡ߶ǶСѪҺANAETܰϸӰ죬ԿTܰϸм٣ԷɢTܰϸֳ

3.ã3.1ԺɸΰH22СǴлƤʹܵã߶ǸںɸΰH22Сǻע200mgkg×2죬ڵ10촦ȡˮ취ÿϸΪ39%ǻע100-200mgkg5죬ʹɰԭӣԭø-6-ø-16-øǿ޴á400mgkgʹɰ󿺽Ƥʹָܻʾ߶Ӧԭãõһҩѧ

3.2ԺɸΰH22СԭۡͷֽøϵãγɹлĵںͻͨؼøУǻ屣̬ҪơѡǴл;СļؼøĻԼ䶯̬仯Ϊָ꣬۲Ч߶ӺɰСԭĻۡ߶ÿ츹ǻע400mgkg5죬ʹ-6-ø(G-6-Pase)Դ217±35267±12umolp˵ʣСʱ-16-ø(F16-Pase)Դ263±25448±56umolp˵/Сʱ絥θǻעͬһG-6-pase1.5Сʱߣ12Сʱ߷壬2448СʱԱڽϸˮƽF-16-Pase1224СʱߣԭҪ24СʱӡԭֽøữøĻûӰ졣ʾ߶ǸҩɰСԭͨԭøԵߣʹ״̬ƶá

3.3.ȡĿãȡ(ҪΪ߶)СֲS-180нŵáʴ50-70%ʴ30%ϡȡƵĺСУԼ6-7%ȫˡȫ˵С1-6ºٽϸȡᆳǻע䡢ע估θȸҩһ¾θЧϸǻע;עҩҲԤҩS-180áڵûҩֿЧļ£ȡſáԺСƢ࿹ϸ࣬ŵĴٽγãߺСǻϸɻƷS-180ˮϸ cAMPĺڰϸֳʸߵʵ飬ϸcAMPҲߣһ㰩ϸcAMPϸԽcAMPԽ͡cAMPʹϸϸתͪA-G7ֻL1210ϸϸãмԵá

3.4.ʵ԰ãԴ°BBNN--N-(4-Ƕ)Һ0.25ml(90mg)θÿ2Σ12ܣÿֻܼBBNΪ2.16gͬʱ߸ɷ90gkg ι30ܷܺɲ100%61.1%38.9%ÿֱŵڲ飬ɲ77.8%11.1%66.7%߶BBNķнŵãԶá

4.жԸСıãȻ̼D-ǰǻעСշжԸףշǰǻע߶100-200mgkgΪ4812Сʱҩ1Ρֹβ䷢SGPT½5'-øװø6-øãԸԵıá

5.ã߶ǾзСԷ䲡ЧЧʱ䶼ȽϿֱǰ248Сʱǻע(800rad)ȫС󣬿ʹ30-70%ҩۿڷǻע䶼зЧۣԤЧ۸ߡ߶ǶСѪޱãСƤʵӦȷߡΪ߶ǵĿÿͨڴ-ϵͳĹܣʹ崦Ӧ״̬Ӷǿ˿˵

6.ã߶ǸǻעС48СʱʹСϸ3HһTdRIJǿͬʱϸͷšһгٺЩһʹѪƤͪߣ˿ΪЩͨƤʶʵֵġ

ԡ߶Ƽ20001θҩ100θǻעҩ28죬СȮδԷӦδʵ𺦡°»Ƥ̼δ߶ԶԺʹ̼á

ȡĩ1gϡ10mlˮԡ15min裬ճ״ȡƷĩҺ(1→5)裬״

ơϴɰƬɡ׹ۡɵߣͭϴƤһأУ¶ˮһҹϸУҶһգȥҶɹá

ζʵƽ

龭ƢΣ׾

ΡʪС㲻ˮйкǣ

÷ڷ10-15g衢ɢ

ע⡿ˮʪ߼ɷ

1.ҽѧԴߵҺʪ֤

2.ҽѧšʪ֢߼ɡ

3.䱾ݡĿ衢ʪʣ߽á

ȣˮС㲻(ȥƤ)ߡкʯ()һζˮζȡȥңɰ·ߺϣ(˺ۡ)ӽףС㲻΢ĩˮذ(ĸ¼)ű¾ãһǮǮǮʲһǮƬöˮ룬һ룬ǰټ壬(ұ)γθʪк޶ȣԲʳ(ȥƤ)ⶹޢ(ȥǣ)öư(ȥƤ)һ֡嵷Ϊδ裬̶ÿʮ裬ʳǰˮ¡(ʥ¼)ܣɸ԰̨ͷذΪһذҹת֮ɢ(СƷ)׳ʢŰǣһһϰ綹ΪδȽijɫȥ𶾰գȡΪĩһδȺ裬ͩӴ󣬸ĩ裬ʹɣ˲ɰƿ֮ÿʮ裬¾£¡()Ż¶ϣ˼ˮߣߡߡȷ֡ζΪɢذ(Ҫԡ ɢ)

1.塷ߣˮ֮࣬÷Ŀ

2.ҩķߣйͣϣܳʪС㡣

3.ĿߵܽܿС㣬ͬ벹ҩҲ

4.ݻԡߣʪˮֽ֮ҩҲҩζʵ΢࣬½ʵɢܽƿ֮С㣬ǰűϷ˺ߴȣܷа˷֮ҲϷͼʹűк˷֮Ҳپ̫ȡʶС㲻ߣɢֹ£ʱԣ溮ű״ߣΪ̵磬ɢԶԡУ֮Ҳ

5.ҩƷ塷ζƢͨˮˮкʪкͨܳʪˮףƻ㣬ΪݣͬΪҩʵƢйҩƢҩůƢͬҩƢƢߣйԪ֮

6.ƣʪƢθߣߡкԷ֮Ҳߴν΢ǣҲкνǣҲζ˺Ϊ

7.ɳҩ⡷ߣйˮϴ߸ݡˮ֮ΪԣľܶСɢ֮ˮа׿֮ʪҲ֮ˮаľҲ֮ˮа֦֮֮ľҲζ֮ˮй֦֮ľػ֮Ҳͽ򡢻֮湦

8.桷ߣߡߵȷôˣкͬ˰ȳʪˮȻˮƢˮߣкͬˮȻԾӶ࣬棬λȻвڡغкͬãʾƫ֮ӡʪԿȥȻУѪ½кˮףǢűֹҩаʪڱգ޲ϧΪ֮裬С㣬ȱԹҩУֹкüߣν˶ר˾ˮҺ׺ģ÷Ŀ

10.űˮ

11.ҩۡ˺ߴȣͣʹ

12.ҡйֹʣס

13.ҽѧԴʪҪƣȥļ¡

14.ҽѧšʡ

15.Ŀܡסǡ£ܣС㲻

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